Five-year evaluation of the antimicrobial susceptibility patterns of bacteria causing bloodstream infections in Iran
Introduction: Bloodstream infections (BSI) are a serious cause of morbidity and mortality worldwide. Emerging antimicrobial drug resistance among bacterial pathogens causing BSI can limit therapeutic options and complicate patient management. Methodology: To encourage the prudent use of appropria...
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The Journal of Infection in Developing Countries
2011-09-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/1517 |
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| author | Babak Pourakbari Alireza Sadr Mohammad Taghi Haghi Ashtiani Setareh Mamishi Mahdi Dehghani Shima Mahmoudi Ali Salavati Farhad Asgari |
| author_facet | Babak Pourakbari Alireza Sadr Mohammad Taghi Haghi Ashtiani Setareh Mamishi Mahdi Dehghani Shima Mahmoudi Ali Salavati Farhad Asgari |
| author_sort | Babak Pourakbari |
| collection | DOAJ |
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Introduction: Bloodstream infections (BSI) are a serious cause of morbidity and mortality worldwide. Emerging antimicrobial drug resistance among bacterial pathogens causing BSI can limit therapeutic options and complicate patient management.
Methodology: To encourage the prudent use of appropriate antibiotics in our pediatric population at Children's Medical Center Hospital, Tehran, Iran, we studied the frequency and antibiogram patterns of blood culture isolates from January 2001 to December 2005.
Results: Of 25,223 blood cultures examined, 2,581 (10.23 %) were positive for bacterial growth. The frequency of Gram-positive bacteria isolated was 47.6% (1228 of 2581) and that for Gram-negatives was 52.4% (1353 of 2581). The rates of methicillin (oxacillin) resistance in Staphylococcus aureus and coagulase-negative staphylococci (CoNS) were 79% and 89%, respectively. About 45% of Streptococcus pneumoniae were resistant to trimethoprim-sulfamethoxazole and approximately 66% to penicillin. Among the Gram-negative isolates, Pseudomonas aeruginosa was most frequently isolated, representing 943 (36.7%) over five years. This possibly represents an unrecognized hospital outbreak or contamination of blood culture bottles or other products such as skin disinfectants. Additionally, this pathogen showed extremely high rates of antimicrobial resistance. There were notable differences in frequency of the five most common microorganisms isolated from blood cultures, which can help set priorities for focused infection control efforts.
Conclusions: Our findings underscore the need to monitor blood culture isolates and their antimicrobial resistance patterns to observe resistance trends that would influence appropriate empiric treatment and infection control strategies for bacteremic children.
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| format | Article |
| id | doaj-art-ef0b1b9fa13c46d687067ca99dee7934 |
| institution | Kabale University |
| issn | 1972-2680 |
| language | English |
| publishDate | 2011-09-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-ef0b1b9fa13c46d687067ca99dee79342025-08-20T03:48:58ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802011-09-0160210.3855/jidc.1517Five-year evaluation of the antimicrobial susceptibility patterns of bacteria causing bloodstream infections in IranBabak Pourakbari0Alireza Sadr1Mohammad Taghi Haghi Ashtiani2Setareh Mamishi3Mahdi Dehghani4Shima Mahmoudi5Ali Salavati6Farhad Asgari7Pediatrics Infectious Diseases Research Center, Tehran University of Medical Sciences, Tehran, IranSchool of Medicine, Tehran University of Medical SciencesDepartment of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, IranInfectious Diseases Research Center, Tehran University of Medical Sciences,School of Medicine, Tehran University of Medical Sciences, Tehran, IranInfectious Diseases Research Center, Tehran University of Medical Sciences, Tehran, IranStudents’ Scientific Research Center (SSRC), Vice Chancellor for Research Tehran University of Medical Sciences, Tehran, IranChildren Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran Introduction: Bloodstream infections (BSI) are a serious cause of morbidity and mortality worldwide. Emerging antimicrobial drug resistance among bacterial pathogens causing BSI can limit therapeutic options and complicate patient management. Methodology: To encourage the prudent use of appropriate antibiotics in our pediatric population at Children's Medical Center Hospital, Tehran, Iran, we studied the frequency and antibiogram patterns of blood culture isolates from January 2001 to December 2005. Results: Of 25,223 blood cultures examined, 2,581 (10.23 %) were positive for bacterial growth. The frequency of Gram-positive bacteria isolated was 47.6% (1228 of 2581) and that for Gram-negatives was 52.4% (1353 of 2581). The rates of methicillin (oxacillin) resistance in Staphylococcus aureus and coagulase-negative staphylococci (CoNS) were 79% and 89%, respectively. About 45% of Streptococcus pneumoniae were resistant to trimethoprim-sulfamethoxazole and approximately 66% to penicillin. Among the Gram-negative isolates, Pseudomonas aeruginosa was most frequently isolated, representing 943 (36.7%) over five years. This possibly represents an unrecognized hospital outbreak or contamination of blood culture bottles or other products such as skin disinfectants. Additionally, this pathogen showed extremely high rates of antimicrobial resistance. There were notable differences in frequency of the five most common microorganisms isolated from blood cultures, which can help set priorities for focused infection control efforts. Conclusions: Our findings underscore the need to monitor blood culture isolates and their antimicrobial resistance patterns to observe resistance trends that would influence appropriate empiric treatment and infection control strategies for bacteremic children. https://jidc.org/index.php/journal/article/view/1517bloodstream infectionsantimicrobial susceptibilityIran |
| spellingShingle | Babak Pourakbari Alireza Sadr Mohammad Taghi Haghi Ashtiani Setareh Mamishi Mahdi Dehghani Shima Mahmoudi Ali Salavati Farhad Asgari Five-year evaluation of the antimicrobial susceptibility patterns of bacteria causing bloodstream infections in Iran Journal of Infection in Developing Countries bloodstream infections antimicrobial susceptibility Iran |
| title | Five-year evaluation of the antimicrobial susceptibility patterns of bacteria causing bloodstream infections in Iran |
| title_full | Five-year evaluation of the antimicrobial susceptibility patterns of bacteria causing bloodstream infections in Iran |
| title_fullStr | Five-year evaluation of the antimicrobial susceptibility patterns of bacteria causing bloodstream infections in Iran |
| title_full_unstemmed | Five-year evaluation of the antimicrobial susceptibility patterns of bacteria causing bloodstream infections in Iran |
| title_short | Five-year evaluation of the antimicrobial susceptibility patterns of bacteria causing bloodstream infections in Iran |
| title_sort | five year evaluation of the antimicrobial susceptibility patterns of bacteria causing bloodstream infections in iran |
| topic | bloodstream infections antimicrobial susceptibility Iran |
| url | https://jidc.org/index.php/journal/article/view/1517 |
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