Citrullinated ENO1 Vaccine Enhances PD-1 Blockade in Mice Implanted with Murine Triple-Negative Breast Cancer Cells

Citrullinated ENO1 Vaccine Enhances PD-1 Blockade in Mice Implanted with Murine Triple-Negative Breast Cancer Cells

<b>Background/Objectives</b>:Cancer vaccine targets mostly include mutations and overexpressed proteins. However, cancer-associated post-translational modifications (PTMs) may also induce immune responses. Previously, our group established the enzyme protein arginine deiminase type-2 (PA...

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Bibliographic Details
Main Authors: Ricardo A. León-Letelier, Alejandro M. Sevillano-Mantas, Yihui Chen, Soyoung Park, Jody Vykoukal, Johannes F. Fahrmann, Edwin J. Ostrin, Candace Garrett, Rongzhang Dou, Yining Cai, Fu-Chung Hsiao, Jennifer B. Dennison, Eduardo Vilar, Banu K. Arun, Samir Hanash, Hiroyuki Katayama
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Vaccines
Subjects:
cancer vaccine
post-translational modification
immunopeptidome
triple-negative breast cancer
PD-1 blockade
Online Access:https://www.mdpi.com/2076-393X/13/6/629
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