Design and synthesis of new trimethoxylphenyl-linked combretastatin analogues loaded on diamond nanoparticles as a panel for ameliorated solubility and antiproliferative activity

Design and synthesis of new trimethoxylphenyl-linked combretastatin analogues loaded on diamond nanoparticles as a panel for ameliorated solubility and antiproliferative activity

A new series of vinyl amide-, imidazolone-, and triazinone-linked combretastatin A-4 analogues have been designed and synthesised. These compounds have been evaluated for their cytotoxic activity against MDA-MB-231 breast cancer cells. The triazinone-linked combretastatin analogues (6 and 12) exhibi...

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Bibliographic Details
Main Authors: Islam Zaki, Amal M. Y. Moustafa, Botros Y. Beshay, Reham E. Masoud, Mohammed A. I. Elbastawesy, Mohammed A. S. Abourehab, Mohamed Y. Zakaria
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
CA-4
cytotoxicity
docking
tubulin
nanodiamond PEG
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2022.2116016
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