Idiopathic inflammatory myopathy: From muscle biopsy to serology
Idiopathic inflammatory myopathies (IIMs) are heterogeneous group of muscle disorders characterized by variable degree of muscle weakness and muscle inflammation. Various classification systems have been proposed for myositis. However, there remains a diagnostic uncertainty due to the presence of ov...
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| Format: | Article |
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SAGE Publishing
2020-01-01
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| Series: | Indian Journal of Rheumatology |
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| Online Access: | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2020;volume=15;issue=6;spage=123;epage=130;aulast=Verma |
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| _version_ | 1850283530937958400 |
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| author | Ritu Verma Vimal Kumar Paliwal |
| author_facet | Ritu Verma Vimal Kumar Paliwal |
| author_sort | Ritu Verma |
| collection | DOAJ |
| description | Idiopathic inflammatory myopathies (IIMs) are heterogeneous group of muscle disorders characterized by variable degree of muscle weakness and muscle inflammation. Various classification systems have been proposed for myositis. However, there remains a diagnostic uncertainty due to the presence of overlapping clinical and pathological features. Similar treatment outcomes to immunosuppressant drugs further add to diagnostic confusion. Introduction of myositis-specific and myositis-associated autoantibodies has widened the disease spectrum of IIMs. Despite being very crucial for the diagnosis and classification of myositis, these autoantibodies are not always present. Therefore, histopathological features and immunohistochemical markers are considered gold standard for the diagnosis of myositis. A correct diagnosis has important clinical and therapeutic implications. In this review, we have focused on salient clinicopathological features and newly developed serological markers in major subtypes of IIMs. |
| format | Article |
| id | doaj-art-eefaa10fef8b4ef485b9c9c3920b8408 |
| institution | OA Journals |
| issn | 0973-3698 0973-3701 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Indian Journal of Rheumatology |
| spelling | doaj-art-eefaa10fef8b4ef485b9c9c3920b84082025-08-20T01:47:45ZengSAGE PublishingIndian Journal of Rheumatology0973-36980973-37012020-01-0115612313010.4103/injr.injr_165_20Idiopathic inflammatory myopathy: From muscle biopsy to serologyRitu VermaVimal Kumar PaliwalIdiopathic inflammatory myopathies (IIMs) are heterogeneous group of muscle disorders characterized by variable degree of muscle weakness and muscle inflammation. Various classification systems have been proposed for myositis. However, there remains a diagnostic uncertainty due to the presence of overlapping clinical and pathological features. Similar treatment outcomes to immunosuppressant drugs further add to diagnostic confusion. Introduction of myositis-specific and myositis-associated autoantibodies has widened the disease spectrum of IIMs. Despite being very crucial for the diagnosis and classification of myositis, these autoantibodies are not always present. Therefore, histopathological features and immunohistochemical markers are considered gold standard for the diagnosis of myositis. A correct diagnosis has important clinical and therapeutic implications. In this review, we have focused on salient clinicopathological features and newly developed serological markers in major subtypes of IIMs.http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2020;volume=15;issue=6;spage=123;epage=130;aulast=Vermaautoantibodyclassificationdiagnostic criteriainflammatory myopathymuscle biopsy |
| spellingShingle | Ritu Verma Vimal Kumar Paliwal Idiopathic inflammatory myopathy: From muscle biopsy to serology Indian Journal of Rheumatology autoantibody classification diagnostic criteria inflammatory myopathy muscle biopsy |
| title | Idiopathic inflammatory myopathy: From muscle biopsy to serology |
| title_full | Idiopathic inflammatory myopathy: From muscle biopsy to serology |
| title_fullStr | Idiopathic inflammatory myopathy: From muscle biopsy to serology |
| title_full_unstemmed | Idiopathic inflammatory myopathy: From muscle biopsy to serology |
| title_short | Idiopathic inflammatory myopathy: From muscle biopsy to serology |
| title_sort | idiopathic inflammatory myopathy from muscle biopsy to serology |
| topic | autoantibody classification diagnostic criteria inflammatory myopathy muscle biopsy |
| url | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2020;volume=15;issue=6;spage=123;epage=130;aulast=Verma |
| work_keys_str_mv | AT rituverma idiopathicinflammatorymyopathyfrommusclebiopsytoserology AT vimalkumarpaliwal idiopathicinflammatorymyopathyfrommusclebiopsytoserology |