A Prospective Clinical Study Evaluating the Efficacy of Intra-Articular Ozone Therapy for Internal Derangement of the Temporomandibular Joint

Background: Temporomandibular joint (TMJ) internal derangement (ID) is a prevalent disorder causing significant pain and dysfunction. Initial treatment typically involves conservative methods, with ozone gas injection emerging as a potential therapy. This study evaluates the efficacy of intra-articu...

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Bibliographic Details
Main Authors: Venugopal Vaishnavi, Ashish Kumar Shetty, Rithesh Kenchapal Balakrishna
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2025-05-01
Series:Journal of Pharmacy and Bioallied Sciences
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Online Access:https://journals.lww.com/10.4103/jpbs.jpbs_1832_24
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Summary:Background: Temporomandibular joint (TMJ) internal derangement (ID) is a prevalent disorder causing significant pain and dysfunction. Initial treatment typically involves conservative methods, with ozone gas injection emerging as a potential therapy. This study evaluates the efficacy of intra-articular ozone gas injection in treating TMJ ID. Methods: Twenty patients diagnosed with Wilkes stage II and III TMJ ID received ozone gas injections into the periarticular tissues and superior joint space. Maximal interincisal mouth opening and TMJ pain scores were assessed at 28 and 42 days post treatment. Results: There were significant improvements in maximal mouth opening and reductions in TMJ pain scores from baseline to the 42nd day post injection. Conclusion: Intra-articular ozone gas injection offers a minimally invasive, cost-effective treatment for TMJ ID, showing substantial benefits before considering more invasive procedures.
ISSN:0976-4879
0975-7406