Cytotoxic Effects of Srikhandasavam on Ethanol-Induced Neurotoxicity in Hippocampal Cell Cultures
Background: Srikhandasavam is a traditional Ayurvedic herbal formulation known for its potential therapeutic properties, particularly in enhancing overall vitality and digestive health. It is composed of a blend of natural ingredients, including sandalwood, which are fermented to enhance their medic...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
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| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_1157_24 |
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| author | S Kondamma J. Kalaivannan Sumathi Jones C.S. Janaki Dhastagir Sheriff K. Prabhu Deepalakkshmi Balakrishnan Shyamala Sambasivam |
| author_facet | S Kondamma J. Kalaivannan Sumathi Jones C.S. Janaki Dhastagir Sheriff K. Prabhu Deepalakkshmi Balakrishnan Shyamala Sambasivam |
| author_sort | S Kondamma |
| collection | DOAJ |
| description | Background:
Srikhandasavam is a traditional Ayurvedic herbal formulation known for its potential therapeutic properties, particularly in enhancing overall vitality and digestive health. It is composed of a blend of natural ingredients, including sandalwood, which are fermented to enhance their medicinal potency.
Aim:
The present study investigates the neuroprotective effects of Srikhandasavam on hippocampal neurons subjected to ethanol-induced neurotoxicity.
Methods:
The primary focus was to assess cell viability and cytotoxicity in the presence of Srikhandasavam at various concentrations, using hippocampal cell cultures.
Results:
The cytotoxicity results indicated a significant impact at higher concentrations, with 50.3% cell mortality observed at 200 µg/mL of Srikhandasavam. Conversely, the MTT assay revealed that Srikhandasavam offered notable protection against ethanol-induced neurotoxicity, with a 71.8% cell viability rate at the same 200 µg/mL concentration.
Conclusion:
These findings suggest that Srikhandasavam as a potential neuroprotective agent, capable of mitigating ethanol-induced damage in hippocampal neurons while maintaining cell viability at therapeutic concentrations. |
| format | Article |
| id | doaj-art-eef817c584904a8a9ad06bfd01fe6d4f |
| institution | OA Journals |
| issn | 0976-4879 0975-7406 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj-art-eef817c584904a8a9ad06bfd01fe6d4f2025-08-20T02:13:53ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0976-48790975-74062024-12-0116Suppl 5S4727S473010.4103/jpbs.jpbs_1157_24Cytotoxic Effects of Srikhandasavam on Ethanol-Induced Neurotoxicity in Hippocampal Cell CulturesS KondammaJ. KalaivannanSumathi JonesC.S. JanakiDhastagir SheriffK. PrabhuDeepalakkshmi BalakrishnanShyamala SambasivamBackground: Srikhandasavam is a traditional Ayurvedic herbal formulation known for its potential therapeutic properties, particularly in enhancing overall vitality and digestive health. It is composed of a blend of natural ingredients, including sandalwood, which are fermented to enhance their medicinal potency. Aim: The present study investigates the neuroprotective effects of Srikhandasavam on hippocampal neurons subjected to ethanol-induced neurotoxicity. Methods: The primary focus was to assess cell viability and cytotoxicity in the presence of Srikhandasavam at various concentrations, using hippocampal cell cultures. Results: The cytotoxicity results indicated a significant impact at higher concentrations, with 50.3% cell mortality observed at 200 µg/mL of Srikhandasavam. Conversely, the MTT assay revealed that Srikhandasavam offered notable protection against ethanol-induced neurotoxicity, with a 71.8% cell viability rate at the same 200 µg/mL concentration. Conclusion: These findings suggest that Srikhandasavam as a potential neuroprotective agent, capable of mitigating ethanol-induced damage in hippocampal neurons while maintaining cell viability at therapeutic concentrations.https://journals.lww.com/10.4103/jpbs.jpbs_1157_24ayurvedic drugcell viabilityhippocampal neuronsandalwoodsrikhandasavam |
| spellingShingle | S Kondamma J. Kalaivannan Sumathi Jones C.S. Janaki Dhastagir Sheriff K. Prabhu Deepalakkshmi Balakrishnan Shyamala Sambasivam Cytotoxic Effects of Srikhandasavam on Ethanol-Induced Neurotoxicity in Hippocampal Cell Cultures Journal of Pharmacy and Bioallied Sciences ayurvedic drug cell viability hippocampal neuron sandalwood srikhandasavam |
| title | Cytotoxic Effects of Srikhandasavam on Ethanol-Induced Neurotoxicity in Hippocampal Cell Cultures |
| title_full | Cytotoxic Effects of Srikhandasavam on Ethanol-Induced Neurotoxicity in Hippocampal Cell Cultures |
| title_fullStr | Cytotoxic Effects of Srikhandasavam on Ethanol-Induced Neurotoxicity in Hippocampal Cell Cultures |
| title_full_unstemmed | Cytotoxic Effects of Srikhandasavam on Ethanol-Induced Neurotoxicity in Hippocampal Cell Cultures |
| title_short | Cytotoxic Effects of Srikhandasavam on Ethanol-Induced Neurotoxicity in Hippocampal Cell Cultures |
| title_sort | cytotoxic effects of srikhandasavam on ethanol induced neurotoxicity in hippocampal cell cultures |
| topic | ayurvedic drug cell viability hippocampal neuron sandalwood srikhandasavam |
| url | https://journals.lww.com/10.4103/jpbs.jpbs_1157_24 |
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