Cytotoxic Effects of Srikhandasavam on Ethanol-Induced Neurotoxicity in Hippocampal Cell Cultures
Background: Srikhandasavam is a traditional Ayurvedic herbal formulation known for its potential therapeutic properties, particularly in enhancing overall vitality and digestive health. It is composed of a blend of natural ingredients, including sandalwood, which are fermented to enhance their medic...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_1157_24 |
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| Summary: | Background:
Srikhandasavam is a traditional Ayurvedic herbal formulation known for its potential therapeutic properties, particularly in enhancing overall vitality and digestive health. It is composed of a blend of natural ingredients, including sandalwood, which are fermented to enhance their medicinal potency.
Aim:
The present study investigates the neuroprotective effects of Srikhandasavam on hippocampal neurons subjected to ethanol-induced neurotoxicity.
Methods:
The primary focus was to assess cell viability and cytotoxicity in the presence of Srikhandasavam at various concentrations, using hippocampal cell cultures.
Results:
The cytotoxicity results indicated a significant impact at higher concentrations, with 50.3% cell mortality observed at 200 µg/mL of Srikhandasavam. Conversely, the MTT assay revealed that Srikhandasavam offered notable protection against ethanol-induced neurotoxicity, with a 71.8% cell viability rate at the same 200 µg/mL concentration.
Conclusion:
These findings suggest that Srikhandasavam as a potential neuroprotective agent, capable of mitigating ethanol-induced damage in hippocampal neurons while maintaining cell viability at therapeutic concentrations. |
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| ISSN: | 0976-4879 0975-7406 |