Improvement in Paretic Arm Reach-to-Grasp following Low Frequency Repetitive Transcranial Magnetic Stimulation Depends on Object Size: A Pilot Study
Introduction. Low frequency repetitive transcranial magnetic stimulation (LF-rTMS) delivered to the nonlesioned hemisphere has been shown to improve limited function of the paretic upper extremity (UE) following stroke. The outcome measures have largely included clinical assessments with little inve...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Stroke Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2015/498169 |
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| author | Jarugool Tretriluxana Shailesh Kantak Suradej Tretriluxana Allan D. Wu Beth E. Fisher |
| author_facet | Jarugool Tretriluxana Shailesh Kantak Suradej Tretriluxana Allan D. Wu Beth E. Fisher |
| author_sort | Jarugool Tretriluxana |
| collection | DOAJ |
| description | Introduction. Low frequency repetitive transcranial magnetic stimulation (LF-rTMS) delivered to the nonlesioned hemisphere has been shown to improve limited function of the paretic upper extremity (UE) following stroke. The outcome measures have largely included clinical assessments with little investigation on changes in kinematics and coordination. To date, there is no study investigating how the effects of LF-rTMS are modulated by the sizes of an object to be grasped. Objective. To investigate the effect of LF-rTMS on kinematics and coordination of the paretic hand reach-to-grasp (RTG) for two object sizes in chronic stroke. Methods. Nine participants received two TMS conditions: real rTMS and sham rTMS conditions. Before and after the rTMS conditions, cortico-motor excitability (CE) of the nonlesioned hemisphere, RTG kinematics, and coordination was evaluated. Object sizes were 1.2 and 7.2 cm in diameter. Results. Compared to sham rTMS, real rTMS significantly reduced CE of the non-lesioned M1. While rTMS had no effect on RTG action for the larger object, real rTMS significantly improved movement time, aperture opening, and RTG coordination for the smaller object. Conclusions. LF-rTMS improves RTG action for only the smaller object in chronic stroke. The findings suggest a dissociation between effects of rTMS on M1 and task difficulty for this complex skill. |
| format | Article |
| id | doaj-art-eef29f719a784e86a9d606bd5f0693e1 |
| institution | Kabale University |
| issn | 2090-8105 2042-0056 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stroke Research and Treatment |
| spelling | doaj-art-eef29f719a784e86a9d606bd5f0693e12025-02-03T05:52:49ZengWileyStroke Research and Treatment2090-81052042-00562015-01-01201510.1155/2015/498169498169Improvement in Paretic Arm Reach-to-Grasp following Low Frequency Repetitive Transcranial Magnetic Stimulation Depends on Object Size: A Pilot StudyJarugool Tretriluxana0Shailesh Kantak1Suradej Tretriluxana2Allan D. Wu3Beth E. Fisher4Faculty of Physical Therapy, Mahidol University, Nakhon Pathom 73170, ThailandNeuroplasticity and Motor Behavior Laboratory, Rehabilitation Research Institute, Elkins Park, PA 19027, USAFaculty of Engineering, King Mongkut’s Institute of Technology Ladkrabang, Bangkok 10520, ThailandDepartment of Neurology, University of California Los Angeles, Los Angeles, CA 90095, USADivision of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA 90089, USAIntroduction. Low frequency repetitive transcranial magnetic stimulation (LF-rTMS) delivered to the nonlesioned hemisphere has been shown to improve limited function of the paretic upper extremity (UE) following stroke. The outcome measures have largely included clinical assessments with little investigation on changes in kinematics and coordination. To date, there is no study investigating how the effects of LF-rTMS are modulated by the sizes of an object to be grasped. Objective. To investigate the effect of LF-rTMS on kinematics and coordination of the paretic hand reach-to-grasp (RTG) for two object sizes in chronic stroke. Methods. Nine participants received two TMS conditions: real rTMS and sham rTMS conditions. Before and after the rTMS conditions, cortico-motor excitability (CE) of the nonlesioned hemisphere, RTG kinematics, and coordination was evaluated. Object sizes were 1.2 and 7.2 cm in diameter. Results. Compared to sham rTMS, real rTMS significantly reduced CE of the non-lesioned M1. While rTMS had no effect on RTG action for the larger object, real rTMS significantly improved movement time, aperture opening, and RTG coordination for the smaller object. Conclusions. LF-rTMS improves RTG action for only the smaller object in chronic stroke. The findings suggest a dissociation between effects of rTMS on M1 and task difficulty for this complex skill.http://dx.doi.org/10.1155/2015/498169 |
| spellingShingle | Jarugool Tretriluxana Shailesh Kantak Suradej Tretriluxana Allan D. Wu Beth E. Fisher Improvement in Paretic Arm Reach-to-Grasp following Low Frequency Repetitive Transcranial Magnetic Stimulation Depends on Object Size: A Pilot Study Stroke Research and Treatment |
| title | Improvement in Paretic Arm Reach-to-Grasp following Low Frequency Repetitive Transcranial Magnetic Stimulation Depends on Object Size: A Pilot Study |
| title_full | Improvement in Paretic Arm Reach-to-Grasp following Low Frequency Repetitive Transcranial Magnetic Stimulation Depends on Object Size: A Pilot Study |
| title_fullStr | Improvement in Paretic Arm Reach-to-Grasp following Low Frequency Repetitive Transcranial Magnetic Stimulation Depends on Object Size: A Pilot Study |
| title_full_unstemmed | Improvement in Paretic Arm Reach-to-Grasp following Low Frequency Repetitive Transcranial Magnetic Stimulation Depends on Object Size: A Pilot Study |
| title_short | Improvement in Paretic Arm Reach-to-Grasp following Low Frequency Repetitive Transcranial Magnetic Stimulation Depends on Object Size: A Pilot Study |
| title_sort | improvement in paretic arm reach to grasp following low frequency repetitive transcranial magnetic stimulation depends on object size a pilot study |
| url | http://dx.doi.org/10.1155/2015/498169 |
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