Unveiling the Larvicidal Potential of Golpar (<i>Heracleum persicum</i> Desf. ex Fisch.) Essential Oil and Its Main Constituents on <i>Aedes</i> and <i>Anopheles</i> Mosquito Vectors
Natural products are thoroughly studied as valuable alternatives to synthetic insecticides. <i>Heracleum persicum</i> Desf. ex Fisch. (Apiaceae), commonly known as Golpar, is an Iranian medicinal plant largely employed as a spice, which has previously revealed insecticidal potential. The...
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2024-10-01
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| author | Marta Ferrati Cecilia Baldassarri Paolo Rossi Guido Favia Giovanni Benelli Livia De Fazi Mohammad Reza Morshedloo Luana Quassinti Riccardo Petrelli Eleonora Spinozzi Filippo Maggi |
| author_facet | Marta Ferrati Cecilia Baldassarri Paolo Rossi Guido Favia Giovanni Benelli Livia De Fazi Mohammad Reza Morshedloo Luana Quassinti Riccardo Petrelli Eleonora Spinozzi Filippo Maggi |
| author_sort | Marta Ferrati |
| collection | DOAJ |
| description | Natural products are thoroughly studied as valuable alternatives to synthetic insecticides. <i>Heracleum persicum</i> Desf. ex Fisch. (Apiaceae), commonly known as Golpar, is an Iranian medicinal plant largely employed as a spice, which has previously revealed insecticidal potential. The chemical composition of <i>H. persicum</i> essential oil (EO) was investigated by GC-MS and was mainly dominated by hexyl butyrate (36.1%) and octyl acetate (23.7%). The EO and its main esters were tested on three mosquito species. <i>Aedes aegypti</i> (L.) larvae were the most sensitive to all tested products. Lethal concentrations (LC<sub>50</sub>) of 59.09, 53.59, and 47.05 ppm were recorded for the EO, hexyl butyrate, and octyl acetate, respectively. <i>Aedes albopictus</i> (Skuse) and <i>Anopheles gambiae</i> Giles demonstrated comparable sensitivity to the EO, with LC<sub>50</sub> values of 102.97 and 97.91 ppm, respectively, whereas the isolated constituents appeared more active on <i>An. gambiae</i> (LC<sub>50</sub> of hexyl butyrate and octyl acetate of 70.97 and 60.71 ppm, respectively) with respect to <i>Ae. albopictus</i> (LC<sub>50</sub> of hexyl butyrate and octyl acetate of 85.40 and 91.38 ppm, respectively). Low toxicity was registered for both EO and single components against human embryonic kidney (HEK293) cells. Overall, the <i>H. persicum</i> EO, hexyl butyrate, and octyl acetate could be further considered for larvicide development. |
| format | Article |
| id | doaj-art-eef16fd89edf476db946fb90dc7c5577 |
| institution | Kabale University |
| issn | 2223-7747 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
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| series | Plants |
| spelling | doaj-art-eef16fd89edf476db946fb90dc7c55772024-11-08T14:39:08ZengMDPI AGPlants2223-77472024-10-011321297410.3390/plants13212974Unveiling the Larvicidal Potential of Golpar (<i>Heracleum persicum</i> Desf. ex Fisch.) Essential Oil and Its Main Constituents on <i>Aedes</i> and <i>Anopheles</i> Mosquito VectorsMarta Ferrati0Cecilia Baldassarri1Paolo Rossi2Guido Favia3Giovanni Benelli4Livia De Fazi5Mohammad Reza Morshedloo6Luana Quassinti7Riccardo Petrelli8Eleonora Spinozzi9Filippo Maggi10Chemistry Interdisciplinary Project (ChIP), School of Pharmacy, University of Camerino, Via Madonna delle Carceri, 62032 Camerino, ItalySchool of Biosciences and Veterinary Medicine, University of Camerino, Via Gentile III Da Varano, 62032 Camerino, ItalySchool of Biosciences and Veterinary Medicine, University of Camerino, Via Gentile III Da Varano, 62032 Camerino, ItalySchool of Biosciences and Veterinary Medicine, University of Camerino, Via Gentile III Da Varano, 62032 Camerino, ItalyDepartment of Agriculture, Food and Environment, University of Pisa, Via del Borghetto 80, 56124 Pisa, ItalyDepartment of Agriculture, Food and Environment, University of Pisa, Via del Borghetto 80, 56124 Pisa, ItalyDepartment of Horticultural Science, Faculty of Agriculture, University of Maragheh, Maragheh 551877684, IranSchool of Pharmacy, University of Camerino, Via Gentile III Da Varano, 62032 Camerino, ItalyChemistry Interdisciplinary Project (ChIP), School of Pharmacy, University of Camerino, Via Madonna delle Carceri, 62032 Camerino, ItalyChemistry Interdisciplinary Project (ChIP), School of Pharmacy, University of Camerino, Via Madonna delle Carceri, 62032 Camerino, ItalyChemistry Interdisciplinary Project (ChIP), School of Pharmacy, University of Camerino, Via Madonna delle Carceri, 62032 Camerino, ItalyNatural products are thoroughly studied as valuable alternatives to synthetic insecticides. <i>Heracleum persicum</i> Desf. ex Fisch. (Apiaceae), commonly known as Golpar, is an Iranian medicinal plant largely employed as a spice, which has previously revealed insecticidal potential. The chemical composition of <i>H. persicum</i> essential oil (EO) was investigated by GC-MS and was mainly dominated by hexyl butyrate (36.1%) and octyl acetate (23.7%). The EO and its main esters were tested on three mosquito species. <i>Aedes aegypti</i> (L.) larvae were the most sensitive to all tested products. Lethal concentrations (LC<sub>50</sub>) of 59.09, 53.59, and 47.05 ppm were recorded for the EO, hexyl butyrate, and octyl acetate, respectively. <i>Aedes albopictus</i> (Skuse) and <i>Anopheles gambiae</i> Giles demonstrated comparable sensitivity to the EO, with LC<sub>50</sub> values of 102.97 and 97.91 ppm, respectively, whereas the isolated constituents appeared more active on <i>An. gambiae</i> (LC<sub>50</sub> of hexyl butyrate and octyl acetate of 70.97 and 60.71 ppm, respectively) with respect to <i>Ae. albopictus</i> (LC<sub>50</sub> of hexyl butyrate and octyl acetate of 85.40 and 91.38 ppm, respectively). Low toxicity was registered for both EO and single components against human embryonic kidney (HEK293) cells. Overall, the <i>H. persicum</i> EO, hexyl butyrate, and octyl acetate could be further considered for larvicide development.https://www.mdpi.com/2223-7747/13/21/2974Apiaceae<i>Aedes aegypti</i><i>Aedes albopictus</i><i>Anopheles gambiae</i>octyl acetatehexyl butyrate |
| spellingShingle | Marta Ferrati Cecilia Baldassarri Paolo Rossi Guido Favia Giovanni Benelli Livia De Fazi Mohammad Reza Morshedloo Luana Quassinti Riccardo Petrelli Eleonora Spinozzi Filippo Maggi Unveiling the Larvicidal Potential of Golpar (<i>Heracleum persicum</i> Desf. ex Fisch.) Essential Oil and Its Main Constituents on <i>Aedes</i> and <i>Anopheles</i> Mosquito Vectors Plants Apiaceae <i>Aedes aegypti</i> <i>Aedes albopictus</i> <i>Anopheles gambiae</i> octyl acetate hexyl butyrate |
| title | Unveiling the Larvicidal Potential of Golpar (<i>Heracleum persicum</i> Desf. ex Fisch.) Essential Oil and Its Main Constituents on <i>Aedes</i> and <i>Anopheles</i> Mosquito Vectors |
| title_full | Unveiling the Larvicidal Potential of Golpar (<i>Heracleum persicum</i> Desf. ex Fisch.) Essential Oil and Its Main Constituents on <i>Aedes</i> and <i>Anopheles</i> Mosquito Vectors |
| title_fullStr | Unveiling the Larvicidal Potential of Golpar (<i>Heracleum persicum</i> Desf. ex Fisch.) Essential Oil and Its Main Constituents on <i>Aedes</i> and <i>Anopheles</i> Mosquito Vectors |
| title_full_unstemmed | Unveiling the Larvicidal Potential of Golpar (<i>Heracleum persicum</i> Desf. ex Fisch.) Essential Oil and Its Main Constituents on <i>Aedes</i> and <i>Anopheles</i> Mosquito Vectors |
| title_short | Unveiling the Larvicidal Potential of Golpar (<i>Heracleum persicum</i> Desf. ex Fisch.) Essential Oil and Its Main Constituents on <i>Aedes</i> and <i>Anopheles</i> Mosquito Vectors |
| title_sort | unveiling the larvicidal potential of golpar i heracleum persicum i desf ex fisch essential oil and its main constituents on i aedes i and i anopheles i mosquito vectors |
| topic | Apiaceae <i>Aedes aegypti</i> <i>Aedes albopictus</i> <i>Anopheles gambiae</i> octyl acetate hexyl butyrate |
| url | https://www.mdpi.com/2223-7747/13/21/2974 |
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