A study of serum brain-derived neurotrophic factor level in individuals with obsessive compulsive disorder and their first-degree relatives as compared to the healthy population
Background: The nosological tradition in psychiatry defines diagnostic criteria for disorders based on expert consensus than objective biological markers reflecting underlying neurobiological correlates. Endophenotypes have been researched as heritable biological markers that can be quantified and d...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-09-01
|
| Series: | Indian Journal of Psychiatry |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/indianjpsychiatry.indianjpsychiatry_290_23 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1825206199312711680 |
|---|---|
| author | Shaily Mina Rupam Dhiman Prakamya Singal Sukanya Gangopadhyay Pankaj Verma Shivani Kathuria |
| author_facet | Shaily Mina Rupam Dhiman Prakamya Singal Sukanya Gangopadhyay Pankaj Verma Shivani Kathuria |
| author_sort | Shaily Mina |
| collection | DOAJ |
| description | Background:
The nosological tradition in psychiatry defines diagnostic criteria for disorders based on expert consensus than objective biological markers reflecting underlying neurobiological correlates. Endophenotypes have been researched as heritable biological markers that can be quantified and defined to represent intermediate measures of a psychiatric illness. In obsessive-compulsive disorder (OCD), various putative biomarkers such as neuropsychological, neurophysiological, neuroradiological, brain-derived neurotrophic factor (BDNF), etc., have been explored.
Aim:
The study aimed to compare levels of serum BDNF in individuals with OCD and their unaffected first-degree relatives (FDR) with healthy controls (HC).
Methods:
This cross-sectional study compared serum BDNF levels in medication-free/naive individuals with OCD (n = 30) to their FDR (n = 30) and age-sex matched HC (n = 30). Intergroup comparison was done using analysis of variance (ANOVA) and post-hoc Tukey’s test. Correlation analysis was conducted to find the relationship of sociodemographic and clinical correlates to serum BDNF as well as dimensional subtypes of OCD.
Results:
No significant difference in BDNF levels was observed between OCD and HC (P = 0.13) but a significantly higher level was found in the FDR group compared to age-sex matched HC (P = 0.02).
Conclusion:
BDNF levels may have a complex interplay influencing the genetic inheritance and clinical manifestations of OCD. Further research is required before considering it a viable biomarker. |
| format | Article |
| id | doaj-art-eef069e2093d405abca7276f6f528425 |
| institution | Kabale University |
| issn | 0019-5545 1998-3794 |
| language | English |
| publishDate | 2023-09-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Psychiatry |
| spelling | doaj-art-eef069e2093d405abca7276f6f5284252025-02-07T12:42:11ZengWolters Kluwer Medknow PublicationsIndian Journal of Psychiatry0019-55451998-37942023-09-0165992292710.4103/indianjpsychiatry.indianjpsychiatry_290_23A study of serum brain-derived neurotrophic factor level in individuals with obsessive compulsive disorder and their first-degree relatives as compared to the healthy populationShaily MinaRupam DhimanPrakamya SingalSukanya GangopadhyayPankaj VermaShivani KathuriaBackground: The nosological tradition in psychiatry defines diagnostic criteria for disorders based on expert consensus than objective biological markers reflecting underlying neurobiological correlates. Endophenotypes have been researched as heritable biological markers that can be quantified and defined to represent intermediate measures of a psychiatric illness. In obsessive-compulsive disorder (OCD), various putative biomarkers such as neuropsychological, neurophysiological, neuroradiological, brain-derived neurotrophic factor (BDNF), etc., have been explored. Aim: The study aimed to compare levels of serum BDNF in individuals with OCD and their unaffected first-degree relatives (FDR) with healthy controls (HC). Methods: This cross-sectional study compared serum BDNF levels in medication-free/naive individuals with OCD (n = 30) to their FDR (n = 30) and age-sex matched HC (n = 30). Intergroup comparison was done using analysis of variance (ANOVA) and post-hoc Tukey’s test. Correlation analysis was conducted to find the relationship of sociodemographic and clinical correlates to serum BDNF as well as dimensional subtypes of OCD. Results: No significant difference in BDNF levels was observed between OCD and HC (P = 0.13) but a significantly higher level was found in the FDR group compared to age-sex matched HC (P = 0.02). Conclusion: BDNF levels may have a complex interplay influencing the genetic inheritance and clinical manifestations of OCD. Further research is required before considering it a viable biomarker.https://journals.lww.com/10.4103/indianjpsychiatry.indianjpsychiatry_290_23bdnfbiomarkerhealthyocdrelatives |
| spellingShingle | Shaily Mina Rupam Dhiman Prakamya Singal Sukanya Gangopadhyay Pankaj Verma Shivani Kathuria A study of serum brain-derived neurotrophic factor level in individuals with obsessive compulsive disorder and their first-degree relatives as compared to the healthy population Indian Journal of Psychiatry bdnf biomarker healthy ocd relatives |
| title | A study of serum brain-derived neurotrophic factor level in individuals with obsessive compulsive disorder and their first-degree relatives as compared to the healthy population |
| title_full | A study of serum brain-derived neurotrophic factor level in individuals with obsessive compulsive disorder and their first-degree relatives as compared to the healthy population |
| title_fullStr | A study of serum brain-derived neurotrophic factor level in individuals with obsessive compulsive disorder and their first-degree relatives as compared to the healthy population |
| title_full_unstemmed | A study of serum brain-derived neurotrophic factor level in individuals with obsessive compulsive disorder and their first-degree relatives as compared to the healthy population |
| title_short | A study of serum brain-derived neurotrophic factor level in individuals with obsessive compulsive disorder and their first-degree relatives as compared to the healthy population |
| title_sort | study of serum brain derived neurotrophic factor level in individuals with obsessive compulsive disorder and their first degree relatives as compared to the healthy population |
| topic | bdnf biomarker healthy ocd relatives |
| url | https://journals.lww.com/10.4103/indianjpsychiatry.indianjpsychiatry_290_23 |
| work_keys_str_mv | AT shailymina astudyofserumbrainderivedneurotrophicfactorlevelinindividualswithobsessivecompulsivedisorderandtheirfirstdegreerelativesascomparedtothehealthypopulation AT rupamdhiman astudyofserumbrainderivedneurotrophicfactorlevelinindividualswithobsessivecompulsivedisorderandtheirfirstdegreerelativesascomparedtothehealthypopulation AT prakamyasingal astudyofserumbrainderivedneurotrophicfactorlevelinindividualswithobsessivecompulsivedisorderandtheirfirstdegreerelativesascomparedtothehealthypopulation AT sukanyagangopadhyay astudyofserumbrainderivedneurotrophicfactorlevelinindividualswithobsessivecompulsivedisorderandtheirfirstdegreerelativesascomparedtothehealthypopulation AT pankajverma astudyofserumbrainderivedneurotrophicfactorlevelinindividualswithobsessivecompulsivedisorderandtheirfirstdegreerelativesascomparedtothehealthypopulation AT shivanikathuria astudyofserumbrainderivedneurotrophicfactorlevelinindividualswithobsessivecompulsivedisorderandtheirfirstdegreerelativesascomparedtothehealthypopulation AT shailymina studyofserumbrainderivedneurotrophicfactorlevelinindividualswithobsessivecompulsivedisorderandtheirfirstdegreerelativesascomparedtothehealthypopulation AT rupamdhiman studyofserumbrainderivedneurotrophicfactorlevelinindividualswithobsessivecompulsivedisorderandtheirfirstdegreerelativesascomparedtothehealthypopulation AT prakamyasingal studyofserumbrainderivedneurotrophicfactorlevelinindividualswithobsessivecompulsivedisorderandtheirfirstdegreerelativesascomparedtothehealthypopulation AT sukanyagangopadhyay studyofserumbrainderivedneurotrophicfactorlevelinindividualswithobsessivecompulsivedisorderandtheirfirstdegreerelativesascomparedtothehealthypopulation AT pankajverma studyofserumbrainderivedneurotrophicfactorlevelinindividualswithobsessivecompulsivedisorderandtheirfirstdegreerelativesascomparedtothehealthypopulation AT shivanikathuria studyofserumbrainderivedneurotrophicfactorlevelinindividualswithobsessivecompulsivedisorderandtheirfirstdegreerelativesascomparedtothehealthypopulation |