Mechanistic insights from the atomic-level quaternary structure of short-lived GPCR oligomers of the human secretin receptor in live cells

Mechanistic insights from the atomic-level quaternary structure of short-lived GPCR oligomers of the human secretin receptor in live cells

Abstract The functional significance of the interactions between proteins in living cells to form short-lived quaternary structures cannot be overemphasized. Yet, quaternary structure information is not captured by current methods; nor can those methods determine structure within living cells. The d...

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Main Authors: Michael R. Stoneman, Thomas D. Killeen, Koki Yokoi, Gabriel Biener, Sanam Bista, Dhruba P. Adhikari, Sadia Rahman, Kaleeckal G. Harikumar, Laurence J. Miller, Ionel Popa, Valerică Raicu
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08374-4
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