Pan-cancer analysis identifies tRNA modification enzyme CTU2 as a novel tumor biomarker and its role in immune microenvironment

Pan-cancer analysis identifies tRNA modification enzyme CTU2 as a novel tumor biomarker and its role in immune microenvironment

BackgroundRecent studies have highlighted dysregulated tRNA modifications in the reprogramming of tumor translation. Cytosolic thiouridylase subunit 2 (CTU2) is an essential and conserved enzyme that modifies tRNA at the wobble position. However, the relationship between CTU2 expression and various...

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Bibliographic Details
Main Authors: Jiaojiao Wang, Chang Gao, Junyi Zhang, Huahong Luo, Siqi Dai, Jianwei Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
CTU2
tRNA modification
pan-cancer
immune microenvironment
prognosis
USF1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1547794/full
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