Acupuncture alleviates hemorrhagic transformation after delayed rt-PA treatment for acute ischemic stroke by regulating the mitophagy-NLRP3 inflammasome pathway

Acupuncture alleviates hemorrhagic transformation after delayed rt-PA treatment for acute ischemic stroke by regulating the mitophagy-NLRP3 inflammasome pathway

BackgroundThe clinical application of recombinant tissue plasminogen activator (rt-PA) is significantly constrained by hemorrhagic transformation (HT), a common and severe complication following thrombolysis for ischemic stroke. Notably, the mitochondrial injury-mediated NLRP3 inflammasome plays a c...

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Bibliographic Details
Main Authors: Tao Jiang, Qianqian Liu, Huanhuan Liu, Zheng Huang, Mengning Yang, Peiyan Huang, Yiting Shen, Yangyang Song, Wentao Xu, Xinchang Zhang, Guangxia Ni
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Neurology
Subjects:
acupuncture
mitophagy
NLRP3 inflammasome
hemorrhagic transformation
rt-PA thrombolysis
acute ischemic stroke
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2025.1533092/full
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