Assessment of the prognostic factors in patients with pulmonary carcinoid tumor: a population‐based study
Abstract Previous studies have identified potential risk factors for pulmonary carcinoid tumors and evaluated the effect of various treatments; however, the results were not entirely consistent. We conducted a population‐based study to further explore relevant prognostic issues. We extracted cases w...
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| Format: | Article |
| Language: | English |
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Wiley
2018-06-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.1515 |
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| author | Yiwei Huang Xiaodong Yang Tao Lu Ming Li Mengnan Zhao Xingyu Yang Ke Ma Shuai Wang Cheng Zhan Yu Liu Qun Wang |
| author_facet | Yiwei Huang Xiaodong Yang Tao Lu Ming Li Mengnan Zhao Xingyu Yang Ke Ma Shuai Wang Cheng Zhan Yu Liu Qun Wang |
| author_sort | Yiwei Huang |
| collection | DOAJ |
| description | Abstract Previous studies have identified potential risk factors for pulmonary carcinoid tumors and evaluated the effect of various treatments; however, the results were not entirely consistent. We conducted a population‐based study to further explore relevant prognostic issues. We extracted cases with pulmonary carcinoid tumors from the Surveillance Epidemiology and End Results database. Cox proportional hazard regression was utilized to identify potential significant risk factors, which helped establish a nomogram for predicting long‐term survival. Survival analysis and a competing risk study were conducted to evaluate the value of different surgical approaches. There were 7057 cases included in the study. Univariate and multivariate analyses showed that age, sex, tumor size, stage, histology, surgical type, chemotherapy, and radiation therapy were all significant prognostic factors. A nomogram with good accuracy for predicting 10‐year survival was formulated. Furthermore, patients who had undergone surgery had a significantly better survival than those who did not undergo surgery. There was no significant prognostic difference between lobectomy and sublobectomy stratified by tumor stage; however, lobectomy was associated with a significantly better survival in atypical tumors, especially those with regional disease. Our research identified possible risk factors in a large cohort and constructed a nomogram to visually predict 10‐year survival of pulmonary carcinoid tumors. We showed that lobectomy and sublobectomy should be considered as the mainstay of treatment, especially lobectomies for atypical tumor. |
| format | Article |
| id | doaj-art-eee09c55afb241f897d5cd648875312f |
| institution | DOAJ |
| issn | 2045-7634 |
| language | English |
| publishDate | 2018-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj-art-eee09c55afb241f897d5cd648875312f2025-08-20T03:15:03ZengWileyCancer Medicine2045-76342018-06-01762434244110.1002/cam4.1515Assessment of the prognostic factors in patients with pulmonary carcinoid tumor: a population‐based studyYiwei Huang0Xiaodong Yang1Tao Lu2Ming Li3Mengnan Zhao4Xingyu Yang5Ke Ma6Shuai Wang7Cheng Zhan8Yu Liu9Qun Wang10Department of Thoracic Surgery Zhongshan Hospital Fudan University No. 180, Fenglin Road Shanghai 200032 ChinaDepartment of Thoracic Surgery Zhongshan Hospital Fudan University No. 180, Fenglin Road Shanghai 200032 ChinaDepartment of Thoracic Surgery Zhongshan Hospital Fudan University No. 180, Fenglin Road Shanghai 200032 ChinaEight‐year Program Clinical Medicine Shanghai Medical College Fudan University Shanghai 200032 ChinaDepartment of Thoracic Surgery Zhongshan Hospital Fudan University No. 180, Fenglin Road Shanghai 200032 ChinaEight‐year Program Clinical Medicine Shanghai Medical College Fudan University Shanghai 200032 ChinaDepartment of Thoracic Surgery Zhongshan Hospital Fudan University No. 180, Fenglin Road Shanghai 200032 ChinaDepartment of Thoracic Surgery Zhongshan Hospital Fudan University No. 180, Fenglin Road Shanghai 200032 ChinaDepartment of Thoracic Surgery Zhongshan Hospital Fudan University No. 180, Fenglin Road Shanghai 200032 ChinaDepartment of Thoracic Surgery Zhongshan Hospital Fudan University No. 180, Fenglin Road Shanghai 200032 ChinaDepartment of Thoracic Surgery Zhongshan Hospital Fudan University No. 180, Fenglin Road Shanghai 200032 ChinaAbstract Previous studies have identified potential risk factors for pulmonary carcinoid tumors and evaluated the effect of various treatments; however, the results were not entirely consistent. We conducted a population‐based study to further explore relevant prognostic issues. We extracted cases with pulmonary carcinoid tumors from the Surveillance Epidemiology and End Results database. Cox proportional hazard regression was utilized to identify potential significant risk factors, which helped establish a nomogram for predicting long‐term survival. Survival analysis and a competing risk study were conducted to evaluate the value of different surgical approaches. There were 7057 cases included in the study. Univariate and multivariate analyses showed that age, sex, tumor size, stage, histology, surgical type, chemotherapy, and radiation therapy were all significant prognostic factors. A nomogram with good accuracy for predicting 10‐year survival was formulated. Furthermore, patients who had undergone surgery had a significantly better survival than those who did not undergo surgery. There was no significant prognostic difference between lobectomy and sublobectomy stratified by tumor stage; however, lobectomy was associated with a significantly better survival in atypical tumors, especially those with regional disease. Our research identified possible risk factors in a large cohort and constructed a nomogram to visually predict 10‐year survival of pulmonary carcinoid tumors. We showed that lobectomy and sublobectomy should be considered as the mainstay of treatment, especially lobectomies for atypical tumor.https://doi.org/10.1002/cam4.1515Carcinoid tumorchemotherapynomogramprognostic factorsradiotherapysurgical treatment |
| spellingShingle | Yiwei Huang Xiaodong Yang Tao Lu Ming Li Mengnan Zhao Xingyu Yang Ke Ma Shuai Wang Cheng Zhan Yu Liu Qun Wang Assessment of the prognostic factors in patients with pulmonary carcinoid tumor: a population‐based study Cancer Medicine Carcinoid tumor chemotherapy nomogram prognostic factors radiotherapy surgical treatment |
| title | Assessment of the prognostic factors in patients with pulmonary carcinoid tumor: a population‐based study |
| title_full | Assessment of the prognostic factors in patients with pulmonary carcinoid tumor: a population‐based study |
| title_fullStr | Assessment of the prognostic factors in patients with pulmonary carcinoid tumor: a population‐based study |
| title_full_unstemmed | Assessment of the prognostic factors in patients with pulmonary carcinoid tumor: a population‐based study |
| title_short | Assessment of the prognostic factors in patients with pulmonary carcinoid tumor: a population‐based study |
| title_sort | assessment of the prognostic factors in patients with pulmonary carcinoid tumor a population based study |
| topic | Carcinoid tumor chemotherapy nomogram prognostic factors radiotherapy surgical treatment |
| url | https://doi.org/10.1002/cam4.1515 |
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