Visceral leishmaniasis in Lebanon a report of four cases: case series and review
Introduction: Leishmaniasis comprises a complex of vector-borne diseases, caused by more than 20 species of the protozoan genus Leishmania, and ranging from localized skin ulcers to lethal systemic disease. It is endemic in Asia, Africa, the Americas, and the Mediterranean region. In the Middle Eas...
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The Journal of Infection in Developing Countries
2018-02-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/10157 |
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| author | Oussaima Eldbouni Pierre Abihanna Mona Beaini Afaf Minari Ibrahim Khalife Gladys Gemayel |
| author_facet | Oussaima Eldbouni Pierre Abihanna Mona Beaini Afaf Minari Ibrahim Khalife Gladys Gemayel |
| author_sort | Oussaima Eldbouni |
| collection | DOAJ |
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Introduction: Leishmaniasis comprises a complex of vector-borne diseases, caused by more than 20 species of the protozoan genus Leishmania, and ranging from localized skin ulcers to lethal systemic disease. It is endemic in Asia, Africa, the Americas, and the Mediterranean region. In the Middle East countries like Syria reports high incidence of the disease. In addition to the endemicity of the region for leishmaniasis, the Middle East has seen a great deal of human migration either for earning of livelihood or due to political upheaval in the region. Cutaneous form can be disfiguring but visceral form can be lethal.
Methodology: In this article we report the clinical presentation of 4 cases of visceral leishmaniasis; 3 cases were pediatrics and one immunosuppressed adult patient all of them were from Syria from different regions. The diagnosis was made by bone marrow aspirate; PCR was made for 2 of them and was positive for leishmania infantum. All of them were treated with Amphotericn B lipid formulation (ABELCET) with complete response (definite cure).
Results: We report in this article 4 cases of visceral leishmaniasis treated with amphotericin B lipid complex (Abelcet) following the guidelines with complete remission.
Conclusion: Visceral leishmaniasis is a serious disease and if not treated can lead to death. Lebanon is not known to be endemic for leishmania but since the war the ministry of health reported an outbreak of leishmania and mainly cutaneous leishmania. Here we present 4 cases of visceral leishmania and a review of the latest guidelines on the treatment modalities and protocols.
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| format | Article |
| id | doaj-art-eeda3072ec3b44e795f514fc74d479cf |
| institution | DOAJ |
| issn | 1972-2680 |
| language | English |
| publishDate | 2018-02-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-eeda3072ec3b44e795f514fc74d479cf2025-08-20T02:57:04ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802018-02-011202.110.3855/jidc.10157Visceral leishmaniasis in Lebanon a report of four cases: case series and reviewOussaima Eldbouni0Pierre Abihanna1Mona Beaini2Afaf Minari3Ibrahim Khalife4Gladys Gemayel5Departement of internal medicine infectious diseases division, Rafic Hariri University Hospital, Beirut, LebanonDepartement of internal medicine infectious diseases division, Rafic Hariri University Hospital, Beirut, LebanonDepartement of laboratory, Rafic Hariri University Hospital, Beirut, LebanonDepartement of internal medicine infectious diseases division, Rafic Hariri University Hospital, Beirut, LebanonDepartement of pediatric Hematology oncology division, Rafic Hariri University Hospital, Beirut, LebanonDepartement of pathology and laboratory, American University of Beirut, Beirut, Lebanon Introduction: Leishmaniasis comprises a complex of vector-borne diseases, caused by more than 20 species of the protozoan genus Leishmania, and ranging from localized skin ulcers to lethal systemic disease. It is endemic in Asia, Africa, the Americas, and the Mediterranean region. In the Middle East countries like Syria reports high incidence of the disease. In addition to the endemicity of the region for leishmaniasis, the Middle East has seen a great deal of human migration either for earning of livelihood or due to political upheaval in the region. Cutaneous form can be disfiguring but visceral form can be lethal. Methodology: In this article we report the clinical presentation of 4 cases of visceral leishmaniasis; 3 cases were pediatrics and one immunosuppressed adult patient all of them were from Syria from different regions. The diagnosis was made by bone marrow aspirate; PCR was made for 2 of them and was positive for leishmania infantum. All of them were treated with Amphotericn B lipid formulation (ABELCET) with complete response (definite cure). Results: We report in this article 4 cases of visceral leishmaniasis treated with amphotericin B lipid complex (Abelcet) following the guidelines with complete remission. Conclusion: Visceral leishmaniasis is a serious disease and if not treated can lead to death. Lebanon is not known to be endemic for leishmania but since the war the ministry of health reported an outbreak of leishmania and mainly cutaneous leishmania. Here we present 4 cases of visceral leishmania and a review of the latest guidelines on the treatment modalities and protocols. https://jidc.org/index.php/journal/article/view/10157Visceral leishmanialeishmania casesAmphotericin B lipid complex |
| spellingShingle | Oussaima Eldbouni Pierre Abihanna Mona Beaini Afaf Minari Ibrahim Khalife Gladys Gemayel Visceral leishmaniasis in Lebanon a report of four cases: case series and review Journal of Infection in Developing Countries Visceral leishmania leishmania cases Amphotericin B lipid complex |
| title | Visceral leishmaniasis in Lebanon a report of four cases: case series and review |
| title_full | Visceral leishmaniasis in Lebanon a report of four cases: case series and review |
| title_fullStr | Visceral leishmaniasis in Lebanon a report of four cases: case series and review |
| title_full_unstemmed | Visceral leishmaniasis in Lebanon a report of four cases: case series and review |
| title_short | Visceral leishmaniasis in Lebanon a report of four cases: case series and review |
| title_sort | visceral leishmaniasis in lebanon a report of four cases case series and review |
| topic | Visceral leishmania leishmania cases Amphotericin B lipid complex |
| url | https://jidc.org/index.php/journal/article/view/10157 |
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