Respiratory function in pediatric African SCA patients underwent bone marrow transplantation
Children with sickle cell anemia (SCA) are prone to invasive infections caused by S. pneumonia, H. influenzae, and Plasmodium falciparum. The presence of asthma increases the risk of mortality, and it has been shown an association between the presence of bronchial hyperactivity and the onset of acut...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2017-04-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | http://www.mjhid.org/index.php/mjhid/article/view/2871 |
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| author | Antonella Isgrò Javid Gaziev Marco Marziali Katia Paciaroni Gioia De Angelis Cecilia Alfieri Michela Ribersani Festus Olusola Olowoselu Guido Lucarelli |
| author_facet | Antonella Isgrò Javid Gaziev Marco Marziali Katia Paciaroni Gioia De Angelis Cecilia Alfieri Michela Ribersani Festus Olusola Olowoselu Guido Lucarelli |
| author_sort | Antonella Isgrò |
| collection | DOAJ |
| description | Children with sickle cell anemia (SCA) are prone to invasive infections caused by S. pneumonia, H. influenzae, and Plasmodium falciparum. The presence of asthma increases the risk of mortality, and it has been shown an association between the presence of bronchial hyperactivity and the onset of acute chest syndrome. Like thalassemia, allogeneic hematopoietic stem cell transplantation (HSCT) is curative in most individuals with SCA. We report pulmonary function analyzed by spirometry, before and after transplantation, in a group of Nigerian SCA children. Our results indicate that restrictive pulmonary pattern (RVP) is a common finding in these patients. Although we do not observe significant improvements in lung function after 3-6 months of transplantation, it is useful to perform a spirometric evaluation of these patients at the time of transplant. |
| format | Article |
| id | doaj-art-eece0808eaad4e048ff5c25e18f9fe0e |
| institution | DOAJ |
| issn | 2035-3006 |
| language | English |
| publishDate | 2017-04-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-eece0808eaad4e048ff5c25e18f9fe0e2025-08-20T02:50:59ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062017-04-0191e2017030e201703010.4084/mjhid.2017.0301682Respiratory function in pediatric African SCA patients underwent bone marrow transplantationAntonella IsgròJavid GazievMarco MarzialiKatia PaciaroniGioia De AngelisCecilia AlfieriMichela RibersaniFestus Olusola OlowoseluGuido LucarelliChildren with sickle cell anemia (SCA) are prone to invasive infections caused by S. pneumonia, H. influenzae, and Plasmodium falciparum. The presence of asthma increases the risk of mortality, and it has been shown an association between the presence of bronchial hyperactivity and the onset of acute chest syndrome. Like thalassemia, allogeneic hematopoietic stem cell transplantation (HSCT) is curative in most individuals with SCA. We report pulmonary function analyzed by spirometry, before and after transplantation, in a group of Nigerian SCA children. Our results indicate that restrictive pulmonary pattern (RVP) is a common finding in these patients. Although we do not observe significant improvements in lung function after 3-6 months of transplantation, it is useful to perform a spirometric evaluation of these patients at the time of transplant.http://www.mjhid.org/index.php/mjhid/article/view/2871Sickle cell anemia, children, spirometry, transplant, asthma. |
| spellingShingle | Antonella Isgrò Javid Gaziev Marco Marziali Katia Paciaroni Gioia De Angelis Cecilia Alfieri Michela Ribersani Festus Olusola Olowoselu Guido Lucarelli Respiratory function in pediatric African SCA patients underwent bone marrow transplantation Mediterranean Journal of Hematology and Infectious Diseases Sickle cell anemia, children, spirometry, transplant, asthma. |
| title | Respiratory function in pediatric African SCA patients underwent bone marrow transplantation |
| title_full | Respiratory function in pediatric African SCA patients underwent bone marrow transplantation |
| title_fullStr | Respiratory function in pediatric African SCA patients underwent bone marrow transplantation |
| title_full_unstemmed | Respiratory function in pediatric African SCA patients underwent bone marrow transplantation |
| title_short | Respiratory function in pediatric African SCA patients underwent bone marrow transplantation |
| title_sort | respiratory function in pediatric african sca patients underwent bone marrow transplantation |
| topic | Sickle cell anemia, children, spirometry, transplant, asthma. |
| url | http://www.mjhid.org/index.php/mjhid/article/view/2871 |
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