Outness predicts greater leukocyte telomere length in sexually minoritized men with HIV who use methamphetamine
Objective: This longitudinal study aimed to examine the associations of sexual minority stress and outness with leukocyte telomere length across time among sexually minority men (SMM) with HIV who use methamphetamine. Methods: A sample of 91 SMM with HIV with biologically confirmed recent methamphet...
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Elsevier
2025-10-01
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| Series: | Brain, Behavior, & Immunity - Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666354625001449 |
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| author | Renessa S. Williams Ariana Johnson Michael Miller-Perusse Annesa Flentje Judy Moskowitz Samantha E. Dilworth Keith J. Horvath Adam W. Carrico Brad E. Aouizerat Delaram Ghanooni |
| author_facet | Renessa S. Williams Ariana Johnson Michael Miller-Perusse Annesa Flentje Judy Moskowitz Samantha E. Dilworth Keith J. Horvath Adam W. Carrico Brad E. Aouizerat Delaram Ghanooni |
| author_sort | Renessa S. Williams |
| collection | DOAJ |
| description | Objective: This longitudinal study aimed to examine the associations of sexual minority stress and outness with leukocyte telomere length across time among sexually minority men (SMM) with HIV who use methamphetamine. Methods: A sample of 91 SMM with HIV with biologically confirmed recent methamphetamine use completed measures of sexual minority stress and outness at the baseline visit in a randomized controlled trial. Telomere length was measured over 15 months using extracted leukocyte DNA Statistical analyses were performed using bivariate analyses and generalized estimation equations to examine the independent association between baseline outness and leukocyte telomere length, adjusting for chronological age and recent stimulant use. Results: Greater outness was significantly associated with longer telomere length (estimate = 0.008; CI: 0.001–0.008) after adjusting for chronological age and stimulant use. There was no evidence that stimulant use, intervention assignment, or race/ethnicity moderated the association between outness and greater leukocyte-telomere length. Sexual minority stress was not significantly associated with leukocyte-telomere length. Conclusion: Findings are among the first to demonstrate that greater outness is associated with slower biological aging in SMM. Further research is needed to elucidate the bio-behavioral mechanisms linking outness and greater leukocyte-telomere length. |
| format | Article |
| id | doaj-art-eecc753f3b6f4ada94f513e66696ca53 |
| institution | Kabale University |
| issn | 2666-3546 |
| language | English |
| publishDate | 2025-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain, Behavior, & Immunity - Health |
| spelling | doaj-art-eecc753f3b6f4ada94f513e66696ca532025-08-20T03:43:55ZengElsevierBrain, Behavior, & Immunity - Health2666-35462025-10-014810108610.1016/j.bbih.2025.101086Outness predicts greater leukocyte telomere length in sexually minoritized men with HIV who use methamphetamineRenessa S. Williams0Ariana Johnson1Michael Miller-Perusse2Annesa Flentje3Judy Moskowitz4Samantha E. Dilworth5Keith J. Horvath6Adam W. Carrico7Brad E. Aouizerat8Delaram Ghanooni9University of Miami School of Nursing and Health Studies, 5030 Brunson Dr Miami, FL, 33146, USA; Corresponding author.University of Miami Miller School of Medicine Department of Public Health Sciences, 1600 NW 10th Ave, Miami, FL, 33136, USASan Diego State University/University of California San Diego, Joint Doctoral Program in Clinical Psychology, San Diego, CA, 92120, USAUniversity of California San Francisco, School of Nursing in Community Health Systems, 2 Koret Way, San Francisco, CA, 94143, USA; Alliance Health Project, Department of Psychiatry and Behavioral Sciences, School of Medicine, University of California, San Francisco, USANorthwestern University, Department of Medical Social Sciences (Intervention Science) Feinberg School of Medicine, 633 N. St Clair, Chicago, IL, 60611, USAUniversity of California, San Francisco School of Medicine, USASan Diego State University/University of California San Diego, Joint Doctoral Program in Clinical Psychology, San Diego, CA, 92120, USA; San Diego State University, Department of Psychology, 6363-250 Alvarado Court, San Diego, CA, 92120, USAFlorida International University Robert Stempel College of Public Health & Social Work, 11200 SW 8th St, Miami, FL, USADepartment of Oral Maxillofacial Surgery, New York University College of Dentistry, USAFlorida International University Robert Stempel College of Public Health & Social Work, 11200 SW 8th St, Miami, FL, USAObjective: This longitudinal study aimed to examine the associations of sexual minority stress and outness with leukocyte telomere length across time among sexually minority men (SMM) with HIV who use methamphetamine. Methods: A sample of 91 SMM with HIV with biologically confirmed recent methamphetamine use completed measures of sexual minority stress and outness at the baseline visit in a randomized controlled trial. Telomere length was measured over 15 months using extracted leukocyte DNA Statistical analyses were performed using bivariate analyses and generalized estimation equations to examine the independent association between baseline outness and leukocyte telomere length, adjusting for chronological age and recent stimulant use. Results: Greater outness was significantly associated with longer telomere length (estimate = 0.008; CI: 0.001–0.008) after adjusting for chronological age and stimulant use. There was no evidence that stimulant use, intervention assignment, or race/ethnicity moderated the association between outness and greater leukocyte-telomere length. Sexual minority stress was not significantly associated with leukocyte-telomere length. Conclusion: Findings are among the first to demonstrate that greater outness is associated with slower biological aging in SMM. Further research is needed to elucidate the bio-behavioral mechanisms linking outness and greater leukocyte-telomere length.http://www.sciencedirect.com/science/article/pii/S2666354625001449AgingHIVLeukocyte telomere lengthMethamphetamineOutnessSexual minority stress |
| spellingShingle | Renessa S. Williams Ariana Johnson Michael Miller-Perusse Annesa Flentje Judy Moskowitz Samantha E. Dilworth Keith J. Horvath Adam W. Carrico Brad E. Aouizerat Delaram Ghanooni Outness predicts greater leukocyte telomere length in sexually minoritized men with HIV who use methamphetamine Brain, Behavior, & Immunity - Health Aging HIV Leukocyte telomere length Methamphetamine Outness Sexual minority stress |
| title | Outness predicts greater leukocyte telomere length in sexually minoritized men with HIV who use methamphetamine |
| title_full | Outness predicts greater leukocyte telomere length in sexually minoritized men with HIV who use methamphetamine |
| title_fullStr | Outness predicts greater leukocyte telomere length in sexually minoritized men with HIV who use methamphetamine |
| title_full_unstemmed | Outness predicts greater leukocyte telomere length in sexually minoritized men with HIV who use methamphetamine |
| title_short | Outness predicts greater leukocyte telomere length in sexually minoritized men with HIV who use methamphetamine |
| title_sort | outness predicts greater leukocyte telomere length in sexually minoritized men with hiv who use methamphetamine |
| topic | Aging HIV Leukocyte telomere length Methamphetamine Outness Sexual minority stress |
| url | http://www.sciencedirect.com/science/article/pii/S2666354625001449 |
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