The use of oral topically acting glucocorticosteroids in the treatment of inflammatory bowel disease
Glucocorticosteroids are the mainstay of treatment of active Crohn's disease and ulcerative colitis. These drugs however carry important cosmetic short-term side effects and when used long-term they induce severe irreversible complications. Topically acting glucocorticosteroids, especially bude...
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| Format: | Article |
| Language: | English |
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Wiley
1998-01-01
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| Series: | Mediators of Inflammation |
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| Online Access: | http://dx.doi.org/10.1080/09629359891036 |
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| author | P. Rutgeerts |
| author_facet | P. Rutgeerts |
| author_sort | P. Rutgeerts |
| collection | DOAJ |
| description | Glucocorticosteroids are the mainstay of treatment of active Crohn's disease and ulcerative colitis. These drugs however carry important cosmetic short-term side effects and when used long-term they induce severe irreversible complications. Topically acting glucocorticosteroids, especially budesonide, have been designed to achieve local effect at the site of inflammation without systemic effects of the drug. The first results of clinical trials are promising and budesonide has been shown to have an improved safety with almost comparable efficacy in comparison with prednisolone. The optimal enema dose seems to be 2 mg/100 ml at night whereas 9 mg o.m. is the optimal dose to treat ileal or right ileocolonic Crohn's disease. Topically acting GCS, like standard GCS are not effective for maintenance of remission of Crohn's disease or recurrence prevention after resection of the involved Crohn's segment. |
| format | Article |
| id | doaj-art-eec91961d12340b48d6090abe7560abd |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1998-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-eec91961d12340b48d6090abe7560abd2025-02-03T07:26:05ZengWileyMediators of Inflammation0962-93511466-18611998-01-017313714010.1080/09629359891036The use of oral topically acting glucocorticosteroids in the treatment of inflammatory bowel diseaseP. Rutgeerts0Department of Gastroenterology, University Hospital Gasthuisberg, Herestraat 49, Leuven 3000, BelgiumGlucocorticosteroids are the mainstay of treatment of active Crohn's disease and ulcerative colitis. These drugs however carry important cosmetic short-term side effects and when used long-term they induce severe irreversible complications. Topically acting glucocorticosteroids, especially budesonide, have been designed to achieve local effect at the site of inflammation without systemic effects of the drug. The first results of clinical trials are promising and budesonide has been shown to have an improved safety with almost comparable efficacy in comparison with prednisolone. The optimal enema dose seems to be 2 mg/100 ml at night whereas 9 mg o.m. is the optimal dose to treat ileal or right ileocolonic Crohn's disease. Topically acting GCS, like standard GCS are not effective for maintenance of remission of Crohn's disease or recurrence prevention after resection of the involved Crohn's segment.http://dx.doi.org/10.1080/09629359891036glucocorticosteroidsCrohn's diseaseulcerative colitis budesomideprednisoloneremission. |
| spellingShingle | P. Rutgeerts The use of oral topically acting glucocorticosteroids in the treatment of inflammatory bowel disease Mediators of Inflammation glucocorticosteroids Crohn's disease ulcerative colitis budesomide prednisolone remission. |
| title | The use of oral topically acting glucocorticosteroids in the treatment of
inflammatory bowel disease |
| title_full | The use of oral topically acting glucocorticosteroids in the treatment of
inflammatory bowel disease |
| title_fullStr | The use of oral topically acting glucocorticosteroids in the treatment of
inflammatory bowel disease |
| title_full_unstemmed | The use of oral topically acting glucocorticosteroids in the treatment of
inflammatory bowel disease |
| title_short | The use of oral topically acting glucocorticosteroids in the treatment of
inflammatory bowel disease |
| title_sort | use of oral topically acting glucocorticosteroids in the treatment of inflammatory bowel disease |
| topic | glucocorticosteroids Crohn's disease ulcerative colitis budesomide prednisolone remission. |
| url | http://dx.doi.org/10.1080/09629359891036 |
| work_keys_str_mv | AT prutgeerts theuseoforaltopicallyactingglucocorticosteroidsinthetreatmentofinflammatoryboweldisease AT prutgeerts useoforaltopicallyactingglucocorticosteroidsinthetreatmentofinflammatoryboweldisease |