Prognostic Value of Cyclin D1 Overexpression in Invasive Breast Carcinoma
Objective: Breast cancer is the most diagnosed cancer worldwide, accounting for 11.7% of all cancers. Cyclin D1, a regulator of CDK4/6 and cell cycle progression, functions as an oncogene through overexpression, contributing to the pathogenesis of cancers including breast carcinoma. This study aimed...
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Atatürk University
2025-04-01
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| Series: | Trends in Surgical Sciences |
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| Online Access: | https://dergipark.org.tr/tr/download/article-file/4752028 |
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| author | Funda Taşlı Enver Vardar Ayşe Yağcı Demet Kocatepe Çavdar Erdem Çomut |
| author_facet | Funda Taşlı Enver Vardar Ayşe Yağcı Demet Kocatepe Çavdar Erdem Çomut |
| author_sort | Funda Taşlı |
| collection | DOAJ |
| description | Objective: Breast cancer is the most diagnosed cancer worldwide, accounting for 11.7% of all cancers. Cyclin D1, a regulator of CDK4/6 and cell cycle progression, functions as an oncogene through overexpression, contributing to the pathogenesis of cancers including breast carcinoma. This study aimed to evaluate Cyclin D1 expression and its clinicopathological significance in invasive breast carcinoma within the Turkish population.Methods: H&E-stained and immunohistochemical preparations from partial and total mastectomy specimens of 143 patients, diagnosed between 2007 and 2013, were examined. Cyclin D1 overexpression was evaluated in 1000 cells using an IHC score based on nuclear staining intensity (0-3) and the percentage of positive tumor cells (1-3), classified as weak ('+' or '++') or strong positive ('+++'). Pearson's Chi-Square and Spearman's rho were used to analyze the relationship between Cyclin D1 expression and clinicopathological parameters statistically.Results: The median age of the patients was 58.5 years (Min:28, Max:92). Cyclin D1 status showed no correlation with age, T stage, or lymph node metastasis. However, a moderate positive correlation was observed with ER (r = 0.32, P <.001) and PR (r = 0.31, P <.001) scores. Among molecular subgroups, Cyclin D1 overexpression was most significant in Luminal B group (92.9%, P = .008), while Triple-negative group showed significantly lower overexpression (40%, P = .008).Conclusion: Cyclin D1 overexpression in Luminal B and Luminal A groups, along with its positive correlation with ER, suggests its role in estrogen-sensitive breast cancer pathogenesis. Strong Cyclin D1 overexpression was associated with reduced survival time in HER2-positive cases. |
| format | Article |
| id | doaj-art-eec4da35508745fbba97505562d2c070 |
| institution | DOAJ |
| issn | 3062-3308 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Atatürk University |
| record_format | Article |
| series | Trends in Surgical Sciences |
| spelling | doaj-art-eec4da35508745fbba97505562d2c0702025-08-20T03:11:57ZengAtatürk UniversityTrends in Surgical Sciences3062-33082025-04-0141233310.61745/tss.167145855Prognostic Value of Cyclin D1 Overexpression in Invasive Breast CarcinomaFunda Taşlı0https://orcid.org/0000-0001-5145-0026Enver Vardar1https://orcid.org/0000-0001-5371-4021Ayşe Yağcı2https://orcid.org/0009-0003-3658-6349Demet Kocatepe Çavdar3https://orcid.org/0000-0002-3278-3770Erdem Çomut4https://orcid.org/0000-0002-3386-4206Department of Pathology, İzmir City Hospital, İzmir, TürkiyeBozyaka Educational and Research Hospital, İzmir, TürkiyeFrozen Pathology Laboratory, İzmir, TürkiyeDepartment of Pathology, İzmir City Hospital, İzmir, TürkiyeDepartment of Pathology, Pamukkale University, Faculty of Medicine, Denizli, TürkiyeObjective: Breast cancer is the most diagnosed cancer worldwide, accounting for 11.7% of all cancers. Cyclin D1, a regulator of CDK4/6 and cell cycle progression, functions as an oncogene through overexpression, contributing to the pathogenesis of cancers including breast carcinoma. This study aimed to evaluate Cyclin D1 expression and its clinicopathological significance in invasive breast carcinoma within the Turkish population.Methods: H&E-stained and immunohistochemical preparations from partial and total mastectomy specimens of 143 patients, diagnosed between 2007 and 2013, were examined. Cyclin D1 overexpression was evaluated in 1000 cells using an IHC score based on nuclear staining intensity (0-3) and the percentage of positive tumor cells (1-3), classified as weak ('+' or '++') or strong positive ('+++'). Pearson's Chi-Square and Spearman's rho were used to analyze the relationship between Cyclin D1 expression and clinicopathological parameters statistically.Results: The median age of the patients was 58.5 years (Min:28, Max:92). Cyclin D1 status showed no correlation with age, T stage, or lymph node metastasis. However, a moderate positive correlation was observed with ER (r = 0.32, P <.001) and PR (r = 0.31, P <.001) scores. Among molecular subgroups, Cyclin D1 overexpression was most significant in Luminal B group (92.9%, P = .008), while Triple-negative group showed significantly lower overexpression (40%, P = .008).Conclusion: Cyclin D1 overexpression in Luminal B and Luminal A groups, along with its positive correlation with ER, suggests its role in estrogen-sensitive breast cancer pathogenesis. Strong Cyclin D1 overexpression was associated with reduced survival time in HER2-positive cases.https://dergipark.org.tr/tr/download/article-file/4752028memeinvaziv meme karsinomucyclin d1histopatolojiimmünohistokimyabreastinvasive breast carcinomacyclin d1histopathologyimmunohistochemistry |
| spellingShingle | Funda Taşlı Enver Vardar Ayşe Yağcı Demet Kocatepe Çavdar Erdem Çomut Prognostic Value of Cyclin D1 Overexpression in Invasive Breast Carcinoma Trends in Surgical Sciences meme invaziv meme karsinomu cyclin d1 histopatoloji immünohistokimya breast invasive breast carcinoma cyclin d1 histopathology immunohistochemistry |
| title | Prognostic Value of Cyclin D1 Overexpression in Invasive Breast Carcinoma |
| title_full | Prognostic Value of Cyclin D1 Overexpression in Invasive Breast Carcinoma |
| title_fullStr | Prognostic Value of Cyclin D1 Overexpression in Invasive Breast Carcinoma |
| title_full_unstemmed | Prognostic Value of Cyclin D1 Overexpression in Invasive Breast Carcinoma |
| title_short | Prognostic Value of Cyclin D1 Overexpression in Invasive Breast Carcinoma |
| title_sort | prognostic value of cyclin d1 overexpression in invasive breast carcinoma |
| topic | meme invaziv meme karsinomu cyclin d1 histopatoloji immünohistokimya breast invasive breast carcinoma cyclin d1 histopathology immunohistochemistry |
| url | https://dergipark.org.tr/tr/download/article-file/4752028 |
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