Successful Treatment of Fetal Intraperitoneal Administration of Immunoglobulin in a Case of Fetal Hemolytic Anemia with 131,072-Fold Anti-E Alloimmunization
Object. We present here the case of severe fetal anemia caused by anti-E antibody positive, which showed a favorable course only with fetal intraperitoneal administration of immunoglobulin. Case. The mother was 31 years old, blood type B Rh : CCDee, gravida 1, with no history of transfusion. Anti-E...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Case Reports in Obstetrics and Gynecology |
| Online Access: | http://dx.doi.org/10.1155/2011/157510 |
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| author | Masashi Yoshida Hideo Matsuda Eijiro Hayata Akio Watanabe Miho Oeda Kenichi Furuya |
| author_facet | Masashi Yoshida Hideo Matsuda Eijiro Hayata Akio Watanabe Miho Oeda Kenichi Furuya |
| author_sort | Masashi Yoshida |
| collection | DOAJ |
| description | Object. We present here the case of severe fetal anemia caused by anti-E antibody positive, which showed a favorable course only with fetal intraperitoneal administration of immunoglobulin. Case. The mother was 31 years old, blood type B Rh : CCDee, gravida 1, with no history of transfusion. Anti-E antibody was detected in the maternal cross-match test at the 18th gestational week. In percutaneous umbilical blood sampling, the umbilical blood hemoglobin level was 9.1 g/dL and the result of the direct Coombs' test was positive at the 26th gestational week. Immunoglobulin injection into fetal abdominal cavity (IFAC) was administered a total 7 times. During the pregnancy, the indirect Coombs' test showed a 131,072-fold increase. Conclusion. In this case, IFAC to block the reticuloendothelial system Fc receptor was successful. This procedure is promising as one of the treatment options for blood group incompatible pregnancy. |
| format | Article |
| id | doaj-art-eec36784d7b042989cefa36eeb45dcad |
| institution | DOAJ |
| issn | 2090-6684 2090-6692 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Obstetrics and Gynecology |
| spelling | doaj-art-eec36784d7b042989cefa36eeb45dcad2025-08-20T03:21:14ZengWileyCase Reports in Obstetrics and Gynecology2090-66842090-66922011-01-01201110.1155/2011/157510157510Successful Treatment of Fetal Intraperitoneal Administration of Immunoglobulin in a Case of Fetal Hemolytic Anemia with 131,072-Fold Anti-E AlloimmunizationMasashi Yoshida0Hideo Matsuda1Eijiro Hayata2Akio Watanabe3Miho Oeda4Kenichi Furuya5Department of Obstetrics and Gynecology, National Defense Medical College, 3-2 Namiki Tokorozawa, Saitama 3598513, JapanDivision of Obstetrics and Gynecology, Matsuda Perinatal Clinic, 1080-5 Hongo, Tokorozawa, Saitama 3590022, JapanDepartment of Obstetrics and Gynecology, National Defense Medical College, 3-2 Namiki Tokorozawa, Saitama 3598513, JapanDepartment of Obstetrics and Gynecology, National Defense Medical College, 3-2 Namiki Tokorozawa, Saitama 3598513, JapanDepartment of Obstetrics and Gynecology, National Defense Medical College, 3-2 Namiki Tokorozawa, Saitama 3598513, JapanDepartment of Obstetrics and Gynecology, National Defense Medical College, 3-2 Namiki Tokorozawa, Saitama 3598513, JapanObject. We present here the case of severe fetal anemia caused by anti-E antibody positive, which showed a favorable course only with fetal intraperitoneal administration of immunoglobulin. Case. The mother was 31 years old, blood type B Rh : CCDee, gravida 1, with no history of transfusion. Anti-E antibody was detected in the maternal cross-match test at the 18th gestational week. In percutaneous umbilical blood sampling, the umbilical blood hemoglobin level was 9.1 g/dL and the result of the direct Coombs' test was positive at the 26th gestational week. Immunoglobulin injection into fetal abdominal cavity (IFAC) was administered a total 7 times. During the pregnancy, the indirect Coombs' test showed a 131,072-fold increase. Conclusion. In this case, IFAC to block the reticuloendothelial system Fc receptor was successful. This procedure is promising as one of the treatment options for blood group incompatible pregnancy.http://dx.doi.org/10.1155/2011/157510 |
| spellingShingle | Masashi Yoshida Hideo Matsuda Eijiro Hayata Akio Watanabe Miho Oeda Kenichi Furuya Successful Treatment of Fetal Intraperitoneal Administration of Immunoglobulin in a Case of Fetal Hemolytic Anemia with 131,072-Fold Anti-E Alloimmunization Case Reports in Obstetrics and Gynecology |
| title | Successful Treatment of Fetal Intraperitoneal Administration of Immunoglobulin in a Case of Fetal Hemolytic Anemia with 131,072-Fold Anti-E Alloimmunization |
| title_full | Successful Treatment of Fetal Intraperitoneal Administration of Immunoglobulin in a Case of Fetal Hemolytic Anemia with 131,072-Fold Anti-E Alloimmunization |
| title_fullStr | Successful Treatment of Fetal Intraperitoneal Administration of Immunoglobulin in a Case of Fetal Hemolytic Anemia with 131,072-Fold Anti-E Alloimmunization |
| title_full_unstemmed | Successful Treatment of Fetal Intraperitoneal Administration of Immunoglobulin in a Case of Fetal Hemolytic Anemia with 131,072-Fold Anti-E Alloimmunization |
| title_short | Successful Treatment of Fetal Intraperitoneal Administration of Immunoglobulin in a Case of Fetal Hemolytic Anemia with 131,072-Fold Anti-E Alloimmunization |
| title_sort | successful treatment of fetal intraperitoneal administration of immunoglobulin in a case of fetal hemolytic anemia with 131 072 fold anti e alloimmunization |
| url | http://dx.doi.org/10.1155/2011/157510 |
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