Intelligent ROS therapy driven by iron-based nanozyme with controllable catalytic activity for infected wound healing
Abstract Therapeutic generation of reactive oxygen species (ROS) through catalytic therapy demonstrates antibacterial efficacy against wound infections. However, prolonged and unregulated ROS production risks inducing intolerable oxidative stress alongside exacerbated inflammatory responses, creatin...
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BMC
2025-06-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-025-03495-8 |
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| author | Lixue Deng Yanni Cheng Jia Liu Ye Yuan Cheng Zhou Chundong Yao Jia Sun Zhixin Zhou Zuoyu Chen Zheng Wang Lin Wang |
| author_facet | Lixue Deng Yanni Cheng Jia Liu Ye Yuan Cheng Zhou Chundong Yao Jia Sun Zhixin Zhou Zuoyu Chen Zheng Wang Lin Wang |
| author_sort | Lixue Deng |
| collection | DOAJ |
| description | Abstract Therapeutic generation of reactive oxygen species (ROS) through catalytic therapy demonstrates antibacterial efficacy against wound infections. However, prolonged and unregulated ROS production risks inducing intolerable oxidative stress alongside exacerbated inflammatory responses, creating a microenvironment counterproductive to wound healing. Here, inspired by rechargeable batteries, we have developed a catalytic activity-controllable nanozyme by integrating Fe(II) and Fe(III) within metal-organic frameworks (FeNZ). Specifically, the overexpressed glutathione in the infective wound can increase the Fe(II) fraction in FeNZ and endow FeNZ with peroxidase (POD)-like activity, which can convert hydrogen peroxide (H2O2) into hydroxyl radicals (•OH) for effective eradication of both drug-sensitive and drug-resistant bacteria (Staphylococcus aureus, 97.9% of antibacterial rate; methicillin-resistant S. aureus (MRSA), 93.2% of antibacterial rate) by disrupting bacterial membranes. Of note, the catalytic performance of FeNZ declined in parallel with the increase in Fe(III) content during the •OH generation process, resulting in a low inflammatory microenvironment for infected wound healing and faster wound healing (95.5% of healing rate for FeNZ + H2O2 group, 83.5% of healing rate for Control group, day 16). The activity-controllable FeNZ thus holds promise as an effective agent for bacterial elimination and enhanced wound repair, presenting a novel strategy for the management of infected wounds. |
| format | Article |
| id | doaj-art-eec34d56ce6f4276bed1ad61ce271c6d |
| institution | OA Journals |
| issn | 1477-3155 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj-art-eec34d56ce6f4276bed1ad61ce271c6d2025-08-20T02:10:31ZengBMCJournal of Nanobiotechnology1477-31552025-06-0123112010.1186/s12951-025-03495-8Intelligent ROS therapy driven by iron-based nanozyme with controllable catalytic activity for infected wound healingLixue Deng0Yanni Cheng1Jia Liu2Ye Yuan3Cheng Zhou4Chundong Yao5Jia Sun6Zhixin Zhou7Zuoyu Chen8Zheng Wang9Lin Wang10Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyResearch Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyResearch Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyResearch Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyResearch Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyResearch Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyResearch Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyResearch Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Therapeutic generation of reactive oxygen species (ROS) through catalytic therapy demonstrates antibacterial efficacy against wound infections. However, prolonged and unregulated ROS production risks inducing intolerable oxidative stress alongside exacerbated inflammatory responses, creating a microenvironment counterproductive to wound healing. Here, inspired by rechargeable batteries, we have developed a catalytic activity-controllable nanozyme by integrating Fe(II) and Fe(III) within metal-organic frameworks (FeNZ). Specifically, the overexpressed glutathione in the infective wound can increase the Fe(II) fraction in FeNZ and endow FeNZ with peroxidase (POD)-like activity, which can convert hydrogen peroxide (H2O2) into hydroxyl radicals (•OH) for effective eradication of both drug-sensitive and drug-resistant bacteria (Staphylococcus aureus, 97.9% of antibacterial rate; methicillin-resistant S. aureus (MRSA), 93.2% of antibacterial rate) by disrupting bacterial membranes. Of note, the catalytic performance of FeNZ declined in parallel with the increase in Fe(III) content during the •OH generation process, resulting in a low inflammatory microenvironment for infected wound healing and faster wound healing (95.5% of healing rate for FeNZ + H2O2 group, 83.5% of healing rate for Control group, day 16). The activity-controllable FeNZ thus holds promise as an effective agent for bacterial elimination and enhanced wound repair, presenting a novel strategy for the management of infected wounds.https://doi.org/10.1186/s12951-025-03495-8Bacterial infectionNanozymeAdjustable enzyme activityChemodynamic therapyWound repair |
| spellingShingle | Lixue Deng Yanni Cheng Jia Liu Ye Yuan Cheng Zhou Chundong Yao Jia Sun Zhixin Zhou Zuoyu Chen Zheng Wang Lin Wang Intelligent ROS therapy driven by iron-based nanozyme with controllable catalytic activity for infected wound healing Journal of Nanobiotechnology Bacterial infection Nanozyme Adjustable enzyme activity Chemodynamic therapy Wound repair |
| title | Intelligent ROS therapy driven by iron-based nanozyme with controllable catalytic activity for infected wound healing |
| title_full | Intelligent ROS therapy driven by iron-based nanozyme with controllable catalytic activity for infected wound healing |
| title_fullStr | Intelligent ROS therapy driven by iron-based nanozyme with controllable catalytic activity for infected wound healing |
| title_full_unstemmed | Intelligent ROS therapy driven by iron-based nanozyme with controllable catalytic activity for infected wound healing |
| title_short | Intelligent ROS therapy driven by iron-based nanozyme with controllable catalytic activity for infected wound healing |
| title_sort | intelligent ros therapy driven by iron based nanozyme with controllable catalytic activity for infected wound healing |
| topic | Bacterial infection Nanozyme Adjustable enzyme activity Chemodynamic therapy Wound repair |
| url | https://doi.org/10.1186/s12951-025-03495-8 |
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