Prevalence of Celiac Disease in Collagenous and Lymphocytic Colitis
Both collagenous and lymphocytic colitis have been described in patients with celiac disease, suggesting an association between the conditions. Over the past few years, the availability, sensitivity and specificity of serological markers for celiac disease have improved - the most recent advance...
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| Format: | Article |
| Language: | English |
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Wiley
2000-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2000/847807 |
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| author | Helen Rachel Gillett Hugh James Freeman |
| author_facet | Helen Rachel Gillett Hugh James Freeman |
| author_sort | Helen Rachel Gillett |
| collection | DOAJ |
| description | Both collagenous and lymphocytic colitis have been described in patients with celiac disease, suggesting an association between the conditions. Over the past few years, the availability, sensitivity and specificity of serological markers for celiac disease have improved - the most recent advancement being the description of tissue transglutaminase as the major antigen for endomysium antibody. A quantitative ELISA was used to measure titres of immunoglobulin A (IgA) antibody to tissue transglutaminase (tTG) along with an immunofluorescent technique for IgA endomysium antibody (EmA) in 15 patients with lymphocytic colitis and eight with collagenous colitis to determine whether celiac disease latency could be detected. One patient with lymphocytic colitis demonstrated both elevated titres of tTG antibody and positive EmA, and small bowel biopsy confirmed celiac disease. One patient with collagenous colitis had a slightly elevated titre of tTG antibody with a negative EmA, and results of a small bowel biopsy were normal. Three other patients with lymphocytic colitis were already treated for previously diagnosed celiac disease. The prevalence of celiac disease occurring in lymphocytic colitis was found to be 27%, but no cases of celiac disease in association with collagenous colitis were found. |
| format | Article |
| id | doaj-art-eec2af77201148a4a0591f82f17e5ece |
| institution | DOAJ |
| issn | 0835-7900 |
| language | English |
| publishDate | 2000-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-eec2af77201148a4a0591f82f17e5ece2025-08-20T03:21:14ZengWileyCanadian Journal of Gastroenterology0835-79002000-01-01141191992110.1155/2000/847807Prevalence of Celiac Disease in Collagenous and Lymphocytic ColitisHelen Rachel Gillett0Hugh James Freeman1Division of Gastroenterology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, CanadaDivision of Gastroenterology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, CanadaBoth collagenous and lymphocytic colitis have been described in patients with celiac disease, suggesting an association between the conditions. Over the past few years, the availability, sensitivity and specificity of serological markers for celiac disease have improved - the most recent advancement being the description of tissue transglutaminase as the major antigen for endomysium antibody. A quantitative ELISA was used to measure titres of immunoglobulin A (IgA) antibody to tissue transglutaminase (tTG) along with an immunofluorescent technique for IgA endomysium antibody (EmA) in 15 patients with lymphocytic colitis and eight with collagenous colitis to determine whether celiac disease latency could be detected. One patient with lymphocytic colitis demonstrated both elevated titres of tTG antibody and positive EmA, and small bowel biopsy confirmed celiac disease. One patient with collagenous colitis had a slightly elevated titre of tTG antibody with a negative EmA, and results of a small bowel biopsy were normal. Three other patients with lymphocytic colitis were already treated for previously diagnosed celiac disease. The prevalence of celiac disease occurring in lymphocytic colitis was found to be 27%, but no cases of celiac disease in association with collagenous colitis were found.http://dx.doi.org/10.1155/2000/847807 |
| spellingShingle | Helen Rachel Gillett Hugh James Freeman Prevalence of Celiac Disease in Collagenous and Lymphocytic Colitis Canadian Journal of Gastroenterology |
| title | Prevalence of Celiac Disease in Collagenous and Lymphocytic Colitis |
| title_full | Prevalence of Celiac Disease in Collagenous and Lymphocytic Colitis |
| title_fullStr | Prevalence of Celiac Disease in Collagenous and Lymphocytic Colitis |
| title_full_unstemmed | Prevalence of Celiac Disease in Collagenous and Lymphocytic Colitis |
| title_short | Prevalence of Celiac Disease in Collagenous and Lymphocytic Colitis |
| title_sort | prevalence of celiac disease in collagenous and lymphocytic colitis |
| url | http://dx.doi.org/10.1155/2000/847807 |
| work_keys_str_mv | AT helenrachelgillett prevalenceofceliacdiseaseincollagenousandlymphocyticcolitis AT hughjamesfreeman prevalenceofceliacdiseaseincollagenousandlymphocyticcolitis |