Metabolomic Prediction of Naphthalene Pneumo-Toxicity in the Snail <i>Helix aspersa maxima</i>
<b>Background:</b> Polluted soils represent a major problem in many industrialized countries that urgently requires appropriate health risk assessment. The One Health concept that considers a close relationship between human and animal health and ecosystems relies, among other techniques...
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MDPI AG
2025-07-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/15/7/448 |
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| author | Aude Devalckeneer Marion Bouviez Jean-Marie Colet |
| author_facet | Aude Devalckeneer Marion Bouviez Jean-Marie Colet |
| author_sort | Aude Devalckeneer |
| collection | DOAJ |
| description | <b>Background:</b> Polluted soils represent a major problem in many industrialized countries that urgently requires appropriate health risk assessment. The One Health concept that considers a close relationship between human and animal health and ecosystems relies, among other techniques, on continuous monitoring through the use of animal species as bioindicators. In this context, terrestrial gastropods, already recognized as relevant indicators due to their anatomo-physiology, provide a reliable model to study the pneumotoxic effects of pollutants. On the other hand, risk assessment is based on multi-biomarker studies. Therefore, omic approaches seem particularly useful since they can simultaneously detect numerous early biological changes. <b>Methods:</b> In this study, <i>Helix aspersa maxima</i> was exposed to naphthalene, a highly volatile aromatic hydrocarbon responsible for numerous respiratory disorders. Pulmonary membrane extracts and hemolymph samples were analyzed by <sup>1</sup>H-NMR spectroscopy after single or repeated exposures to naphthalene. <b>Results:</b> Numerous metabolic changes were observed, which could be related to membrane lesions, energy, anti-inflammatory, and tumorigenesis pathways. <b>Conclusions:</b> Our findings highlight the potential of combining animal indicator and omics techniques to predict respiratory health risks in cases of exposure to polluted soils. |
| format | Article |
| id | doaj-art-eebd4e3d0ed44164a9c28f1fdd4ce07a |
| institution | Kabale University |
| issn | 2218-1989 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj-art-eebd4e3d0ed44164a9c28f1fdd4ce07a2025-08-20T03:32:15ZengMDPI AGMetabolites2218-19892025-07-0115744810.3390/metabo15070448Metabolomic Prediction of Naphthalene Pneumo-Toxicity in the Snail <i>Helix aspersa maxima</i>Aude Devalckeneer0Marion Bouviez1Jean-Marie Colet2Laboratory of Human Biology & Toxicology, Faculty of Medicine and Pharmacy, University of Mons, 7000 Mons, BelgiumLaboratory of Human Biology & Toxicology, Faculty of Medicine and Pharmacy, University of Mons, 7000 Mons, BelgiumLaboratory of Human Biology & Toxicology, Faculty of Medicine and Pharmacy, University of Mons, 7000 Mons, Belgium<b>Background:</b> Polluted soils represent a major problem in many industrialized countries that urgently requires appropriate health risk assessment. The One Health concept that considers a close relationship between human and animal health and ecosystems relies, among other techniques, on continuous monitoring through the use of animal species as bioindicators. In this context, terrestrial gastropods, already recognized as relevant indicators due to their anatomo-physiology, provide a reliable model to study the pneumotoxic effects of pollutants. On the other hand, risk assessment is based on multi-biomarker studies. Therefore, omic approaches seem particularly useful since they can simultaneously detect numerous early biological changes. <b>Methods:</b> In this study, <i>Helix aspersa maxima</i> was exposed to naphthalene, a highly volatile aromatic hydrocarbon responsible for numerous respiratory disorders. Pulmonary membrane extracts and hemolymph samples were analyzed by <sup>1</sup>H-NMR spectroscopy after single or repeated exposures to naphthalene. <b>Results:</b> Numerous metabolic changes were observed, which could be related to membrane lesions, energy, anti-inflammatory, and tumorigenesis pathways. <b>Conclusions:</b> Our findings highlight the potential of combining animal indicator and omics techniques to predict respiratory health risks in cases of exposure to polluted soils.https://www.mdpi.com/2218-1989/15/7/448<sup>1</sup>H-NMRrespiratory toxicitysnailsnaphthalenebiomarkers |
| spellingShingle | Aude Devalckeneer Marion Bouviez Jean-Marie Colet Metabolomic Prediction of Naphthalene Pneumo-Toxicity in the Snail <i>Helix aspersa maxima</i> Metabolites <sup>1</sup>H-NMR respiratory toxicity snails naphthalene biomarkers |
| title | Metabolomic Prediction of Naphthalene Pneumo-Toxicity in the Snail <i>Helix aspersa maxima</i> |
| title_full | Metabolomic Prediction of Naphthalene Pneumo-Toxicity in the Snail <i>Helix aspersa maxima</i> |
| title_fullStr | Metabolomic Prediction of Naphthalene Pneumo-Toxicity in the Snail <i>Helix aspersa maxima</i> |
| title_full_unstemmed | Metabolomic Prediction of Naphthalene Pneumo-Toxicity in the Snail <i>Helix aspersa maxima</i> |
| title_short | Metabolomic Prediction of Naphthalene Pneumo-Toxicity in the Snail <i>Helix aspersa maxima</i> |
| title_sort | metabolomic prediction of naphthalene pneumo toxicity in the snail i helix aspersa maxima i |
| topic | <sup>1</sup>H-NMR respiratory toxicity snails naphthalene biomarkers |
| url | https://www.mdpi.com/2218-1989/15/7/448 |
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