Case Report: Three cases of lung large cell neuroendocrine carcinoma with clinicopathological features of SMARCA4 (BRG1) deficiency

Case Report: Three cases of lung large cell neuroendocrine carcinoma with clinicopathological features of SMARCA4 (BRG1) deficiency

ObjectiveTo investigate the clinicopathological characteristics, differential diagnosis and potential therapeutic targets of SMARCA4-deficient large cell neuroendocrine carcinoma (SD-LCNEC) in the lung.MethodsWe analyzed the clinicopathological features of 3 cases of SD-LCNEC and reviewed relevant l...

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Bibliographic Details
Main Authors:	Fangfang Zou, Jingdan Jia, Yizeng Wang, Xiaochun Fei, Chaofu Wang, Xiaoyan Chen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-06-01
Series:	Frontiers in Oncology
Subjects:	lung neoplasms SMARCA4-deficient large cell neuroendocrine carcinoma immunohistochemistry differential diagnosis
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2025.1538548/full
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