Characterizing and engineering post-translational modifications with high-throughput cell-free expression

Characterizing and engineering post-translational modifications with high-throughput cell-free expression

Abstract Post-translational modifications (PTMs) are important for the stability and function of many therapeutic proteins and peptides. Current methods for studying and engineering PTMs are often limited by low-throughput experimental techniques. Here we describe a generalizable, in vitro workflow...

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Main Authors: Derek A. Wong, Zachary M. Shaver, Maria D. Cabezas, Martin Daniel-Ivad, Katherine F. Warfel, Deepali V. Prasanna, Sarah E. Sobol, Regina Fernandez, Fernando Tobias, Szymon K. Filip, Sophia W. Hulbert, Peter Faull, Robert Nicol, Matthew P. DeLisa, Emily P. Balskus, Ashty S. Karim, Michael C. Jewett
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60526-6
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