Neutrophil Gelatinase-Associated Lipocalin Levels in Early and Late Onset Preeclampsia
Objective: To evaluate the serum neutrophil gelatinase-associated lipocalin levels in pregnant women with and without preeclampsia, early-onset preeclampsia and late-onset preeclampsia, preeclampsia with and without severe features, and investigate the correlation with the neonatal outcomes. Study...
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Medical Network
2020-12-01
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| Series: | Gynecology Obstetrics & Reproductive Medicine |
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| Online Access: | https://gorm.com.tr/index.php/GORM/article/view/918 |
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| author | Onur Guralp Nevin Tuten Mahmut Oncul Serdar A Acikgoz Hakan Ekmekci Abdullah Tuten |
| author_facet | Onur Guralp Nevin Tuten Mahmut Oncul Serdar A Acikgoz Hakan Ekmekci Abdullah Tuten |
| author_sort | Onur Guralp |
| collection | DOAJ |
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Objective: To evaluate the serum neutrophil gelatinase-associated lipocalin levels in pregnant women with and without preeclampsia, early-onset preeclampsia and late-onset preeclampsia, preeclampsia with and without severe features, and investigate the correlation with the neonatal outcomes.
Study Design: A total of 79 pregnant women, 27 with uncomplicated pregnancies, 30 with early-onset preeclampsia, and 22 with late-onset preeclampsia were evaluated in a cross-sectional study. Neutrophil gelatinase-associated lipocalin was measured with a colorimetric Sandwich-ELISA method. Age; body mass index; systolic and diastolic blood pressure; umbilical-artery Doppler results; serum urea, bilirubin, uric acid, AST, ALT; 24-hour protein test; birth-weight; and Apgar-scores were recorded.
Results: Serum neutrophil gelatinase-associated lipocalin levels were significantly higher in women with preeclampsia compared to those without preeclampsia (p<0.001); in women with early-onset preeclampsia compared to those with late-onset preeclampsia (p<0.001); and in women with late-onset preeclampsia compared to those without preeclampsia (p=0.028). Mean serum neutrophil gelatinase-associated lipocalin levels were comparable in women with preeclampsia with and without severe features (p=0.076). The correlation analysis showed that neutrophil gelatinase-associated lipocalin was not affected by age or body mass index. Neutrophil gelatinase-associated lipocalin had a positive correlation with systolic and diastolic blood pressure and the umbilical-artery PI and RI. Serum neutrophil gelatinase-associated lipocalin had a positive correlation with serum urea (r=0.416, p=0.031) however had no significant correlation with birth-weight, Apgar-scores, uric acid and amount of proteinuria in women with preeclampsia.
Conclusion: Serum neutrophil gelatinase-associated lipocalin levels were significantly higher in women with preeclampsia compared to those without preeclampsia; in women with early-onset preeclampsia compared to those with late-onset preeclampsia, and in women with late-onset preeclampsia compared to women without preeclampsia. Mean serum neutrophil gelatinase-associated lipocalin levels were comparable in women with preeclampsia with and without severe features.
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| format | Article |
| id | doaj-art-eeb2f67ec4cb43a88611e9c89f2aa73d |
| institution | Kabale University |
| issn | 1300-4751 2602-4918 |
| language | English |
| publishDate | 2020-12-01 |
| publisher | Medical Network |
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| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj-art-eeb2f67ec4cb43a88611e9c89f2aa73d2025-02-11T21:10:44ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512602-49182020-12-0126310.21613/GORM.2018.918Neutrophil Gelatinase-Associated Lipocalin Levels in Early and Late Onset PreeclampsiaOnur Guralp0Nevin Tuten1Mahmut Oncul2Serdar A Acikgoz3Hakan Ekmekci4Abdullah Tuten5Oldenburg University, Department of Obstetrics and Gynecology, Klinikum Oldenburg, OldenburgDarende State Hospital, Obstetrics and Gynecology Zaviye Mah. Hacı Hulusi Efendi Cad. No No:22, 44700, Darende/Malatya, TurkeyIstanbul Cerrahpasa University, Department of Obstetrics and Gynecology, Kocamustafapasa Cad. No:34/E, 34098, Fatih, Istanbul, TurkeyIstanbul Cerrahpasa University, Department of Obstetrics and Gynecology, Kocamustafapasa Cad. No:34/E, 34098, Fatih, Istanbul, TurkeyIstanbul Cerrahpasa University, Department of Biochemistry, Kocamustafapasa Cad. No:34/E, 34098, Fatih, Istanbul, TurkeyIstanbul Cerrahpasa University, Department of Obstetrics and Gynecology, Kocamustafapasa Cad. No:34/E, 34098, Fatih, Istanbul, Turkey Objective: To evaluate the serum neutrophil gelatinase-associated lipocalin levels in pregnant women with and without preeclampsia, early-onset preeclampsia and late-onset preeclampsia, preeclampsia with and without severe features, and investigate the correlation with the neonatal outcomes. Study Design: A total of 79 pregnant women, 27 with uncomplicated pregnancies, 30 with early-onset preeclampsia, and 22 with late-onset preeclampsia were evaluated in a cross-sectional study. Neutrophil gelatinase-associated lipocalin was measured with a colorimetric Sandwich-ELISA method. Age; body mass index; systolic and diastolic blood pressure; umbilical-artery Doppler results; serum urea, bilirubin, uric acid, AST, ALT; 24-hour protein test; birth-weight; and Apgar-scores were recorded. Results: Serum neutrophil gelatinase-associated lipocalin levels were significantly higher in women with preeclampsia compared to those without preeclampsia (p<0.001); in women with early-onset preeclampsia compared to those with late-onset preeclampsia (p<0.001); and in women with late-onset preeclampsia compared to those without preeclampsia (p=0.028). Mean serum neutrophil gelatinase-associated lipocalin levels were comparable in women with preeclampsia with and without severe features (p=0.076). The correlation analysis showed that neutrophil gelatinase-associated lipocalin was not affected by age or body mass index. Neutrophil gelatinase-associated lipocalin had a positive correlation with systolic and diastolic blood pressure and the umbilical-artery PI and RI. Serum neutrophil gelatinase-associated lipocalin had a positive correlation with serum urea (r=0.416, p=0.031) however had no significant correlation with birth-weight, Apgar-scores, uric acid and amount of proteinuria in women with preeclampsia. Conclusion: Serum neutrophil gelatinase-associated lipocalin levels were significantly higher in women with preeclampsia compared to those without preeclampsia; in women with early-onset preeclampsia compared to those with late-onset preeclampsia, and in women with late-onset preeclampsia compared to women without preeclampsia. Mean serum neutrophil gelatinase-associated lipocalin levels were comparable in women with preeclampsia with and without severe features. https://gorm.com.tr/index.php/GORM/article/view/918PreeclampsiaPreeclampsia with severe featuresProteinuriaUmbilical artery doppler |
| spellingShingle | Onur Guralp Nevin Tuten Mahmut Oncul Serdar A Acikgoz Hakan Ekmekci Abdullah Tuten Neutrophil Gelatinase-Associated Lipocalin Levels in Early and Late Onset Preeclampsia Gynecology Obstetrics & Reproductive Medicine Preeclampsia Preeclampsia with severe features Proteinuria Umbilical artery doppler |
| title | Neutrophil Gelatinase-Associated Lipocalin Levels in Early and Late Onset Preeclampsia |
| title_full | Neutrophil Gelatinase-Associated Lipocalin Levels in Early and Late Onset Preeclampsia |
| title_fullStr | Neutrophil Gelatinase-Associated Lipocalin Levels in Early and Late Onset Preeclampsia |
| title_full_unstemmed | Neutrophil Gelatinase-Associated Lipocalin Levels in Early and Late Onset Preeclampsia |
| title_short | Neutrophil Gelatinase-Associated Lipocalin Levels in Early and Late Onset Preeclampsia |
| title_sort | neutrophil gelatinase associated lipocalin levels in early and late onset preeclampsia |
| topic | Preeclampsia Preeclampsia with severe features Proteinuria Umbilical artery doppler |
| url | https://gorm.com.tr/index.php/GORM/article/view/918 |
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