Cell-type specific reductions in interneuron gene expression within the cingulate gyrus of schizophrenia and bipolar disorder subjects

Cell-type specific reductions in interneuron gene expression within the cingulate gyrus of schizophrenia and bipolar disorder subjects

Abstract Schizophrenia (SZ) and bipolar disorder (BP) patients share overlapping neurocognitive deficits of varied magnitude. Neuroimaging in patients and postmortem gene expression analyses suggest that compromised cingulate gyrus GABA-ergic interneurons may contribute to cognitive impairments in S...

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Main Authors: David M. Krolewski, Huzefa Khalil, Maria Waselus, Marquis P. Vawter, Blynn G. Bunney, Richard M. Myers, Francis S. Y. Lee, Alan F. Schatzberg, William E. Bunney, Huda Akil, Stanley J. Watson
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Schizophrenia
Online Access:https://doi.org/10.1038/s41537-025-00638-6
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