Associations between multiple metals exposure and bone mineral density: a population-based study in U.S. children and adolescents
Abstract Aim This study examined the correlation between multi-metal exposure and bone mineral density (BMD) in U.S. children and adolescents. Methods Data from 1,591 participants (aged 8–19) were analyzed using the National Health and Nutrition Examination Survey (NHANES) 2011–2016. We measured ser...
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BMC
2025-05-01
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| Series: | BMC Musculoskeletal Disorders |
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| Online Access: | https://doi.org/10.1186/s12891-025-08677-x |
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| author | Jian Han Jiaqing Sun Lin Yuan Luyao Lou Xiaofeng Jiang |
| author_facet | Jian Han Jiaqing Sun Lin Yuan Luyao Lou Xiaofeng Jiang |
| author_sort | Jian Han |
| collection | DOAJ |
| description | Abstract Aim This study examined the correlation between multi-metal exposure and bone mineral density (BMD) in U.S. children and adolescents. Methods Data from 1,591 participants (aged 8–19) were analyzed using the National Health and Nutrition Examination Survey (NHANES) 2011–2016. We measured serum copper (Cu), selenium (Se), zinc (Zn), and blood lead (Pb), cadmium (Cd), mercury (Hg), manganese (Mn). Dual-energy X-ray absorptiometry assessed lumbar and total BMD. Advanced statistical approaches including weighted quantile sum (WQS) regression and bayesian kernel machine regression (BKMR) were employed to evaluate complex exposure interactions. Results Blood Pb and serum Cu showed inverse associations with, while serum Se positively correlated with lumbar BMD (blood Pb: β: -0.013, serum Cu: β: -0.063, serum Se: 0.035) (all P < 0.05). The WQS index showed a significant association with both lumbar BMD(β = 0.019, P < 0.05) and total BMD (β = 0.019, P < 0.001). WQS analysis identified Cd, Se, and Hg as primary contributors to both lumbar and total BMD variations. BKMR models revealed nonlinear exposure–response relationships and synergistic effects between Cd and Mn. Conclusion These findings highlight the importance of considering mixed metal exposures in bone health assessments, providing crucial insights for developing preventive strategies to protect skeletal development in pediatric populations. |
| format | Article |
| id | doaj-art-eeaae34a1b4e4fe3803527753431afa0 |
| institution | OA Journals |
| issn | 1471-2474 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj-art-eeaae34a1b4e4fe3803527753431afa02025-08-20T02:15:16ZengBMCBMC Musculoskeletal Disorders1471-24742025-05-0126111210.1186/s12891-025-08677-xAssociations between multiple metals exposure and bone mineral density: a population-based study in U.S. children and adolescentsJian Han0Jiaqing Sun1Lin Yuan2Luyao Lou3Xiaofeng Jiang4Wenyan Branch of the First People’s Hospital of Xiaoshan DistrictWenyan Branch of the First People’s Hospital of Xiaoshan DistrictWenyan Branch of the First People’s Hospital of Xiaoshan DistrictWenyan Branch of the First People’s Hospital of Xiaoshan DistrictWenyan Branch of the First People’s Hospital of Xiaoshan DistrictAbstract Aim This study examined the correlation between multi-metal exposure and bone mineral density (BMD) in U.S. children and adolescents. Methods Data from 1,591 participants (aged 8–19) were analyzed using the National Health and Nutrition Examination Survey (NHANES) 2011–2016. We measured serum copper (Cu), selenium (Se), zinc (Zn), and blood lead (Pb), cadmium (Cd), mercury (Hg), manganese (Mn). Dual-energy X-ray absorptiometry assessed lumbar and total BMD. Advanced statistical approaches including weighted quantile sum (WQS) regression and bayesian kernel machine regression (BKMR) were employed to evaluate complex exposure interactions. Results Blood Pb and serum Cu showed inverse associations with, while serum Se positively correlated with lumbar BMD (blood Pb: β: -0.013, serum Cu: β: -0.063, serum Se: 0.035) (all P < 0.05). The WQS index showed a significant association with both lumbar BMD(β = 0.019, P < 0.05) and total BMD (β = 0.019, P < 0.001). WQS analysis identified Cd, Se, and Hg as primary contributors to both lumbar and total BMD variations. BKMR models revealed nonlinear exposure–response relationships and synergistic effects between Cd and Mn. Conclusion These findings highlight the importance of considering mixed metal exposures in bone health assessments, providing crucial insights for developing preventive strategies to protect skeletal development in pediatric populations.https://doi.org/10.1186/s12891-025-08677-xMultiple metals exposureBone mineral density (BMD)Children and adolescentsCross-sectional study |
| spellingShingle | Jian Han Jiaqing Sun Lin Yuan Luyao Lou Xiaofeng Jiang Associations between multiple metals exposure and bone mineral density: a population-based study in U.S. children and adolescents BMC Musculoskeletal Disorders Multiple metals exposure Bone mineral density (BMD) Children and adolescents Cross-sectional study |
| title | Associations between multiple metals exposure and bone mineral density: a population-based study in U.S. children and adolescents |
| title_full | Associations between multiple metals exposure and bone mineral density: a population-based study in U.S. children and adolescents |
| title_fullStr | Associations between multiple metals exposure and bone mineral density: a population-based study in U.S. children and adolescents |
| title_full_unstemmed | Associations between multiple metals exposure and bone mineral density: a population-based study in U.S. children and adolescents |
| title_short | Associations between multiple metals exposure and bone mineral density: a population-based study in U.S. children and adolescents |
| title_sort | associations between multiple metals exposure and bone mineral density a population based study in u s children and adolescents |
| topic | Multiple metals exposure Bone mineral density (BMD) Children and adolescents Cross-sectional study |
| url | https://doi.org/10.1186/s12891-025-08677-x |
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