Development of ZHPV16E7- granzyme B immunoaffitoxin: dual mechanisms targeting hpv16-positive cervical cancer through epithelial-mesenchymal transition inhibition and cell death

Development of ZHPV16E7- granzyme B immunoaffitoxin: dual mechanisms targeting hpv16-positive cervical cancer through epithelial-mesenchymal transition inhibition and cell death

IntroductionCervical cancer, predominantly caused by high-risk human papillomavirus (HPV), remains a major global health challenge. HPV16 is the most prevalent type, and its oncoprotein E7 promotes epithelial-mesenchymal transition (EMT), a critical step in metastasis. Current therapies for HPV16-re...

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Bibliographic Details
Main Authors: Xiaochun Tan, Jiani Yang, Yanheng Li, Kairong Wan, Sicong Feng, Xishang Jing, Zhenyun Xie, Lifang Zhang, Wenshu Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
HPV16E7
affibody
GrB
cervical cancer
EMT
cell death
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1616715/full
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