Infection-Induced Vulnerability of Perinatal Brain Injury
A growing body of evidence demonstrates that susceptibility and progression of both acute and chronic central nervous system disease in the newborn is closely associated with an innate immune response that can manifest from either direct infection and/or infection-triggered damage. A common feature...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Neurology Research International |
| Online Access: | http://dx.doi.org/10.1155/2012/102153 |
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| _version_ | 1832548646971768832 |
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| author | Carina Mallard Xiaoyang Wang |
| author_facet | Carina Mallard Xiaoyang Wang |
| author_sort | Carina Mallard |
| collection | DOAJ |
| description | A growing body of evidence demonstrates that susceptibility and progression of both acute and chronic central nervous system disease in the newborn is closely associated with an innate immune response that can manifest from either direct infection and/or infection-triggered damage. A common feature of many of these diseases is the systemic exposure of the neonate to bacterial infections that elicit brain inflammation. In recent years, the importance of innate immune receptors in newborn brain injury, the so-called Toll-like receptors, has been demonstrated. In this paper we will discuss how neonatal sepsis, with particular emphasis on Escherichia coli, coagulase-negative staphylococci, and group B streptococcal infections in preterm infants, and Toll-like receptor-mediated inflammation can increase the vulnerability of the newborn brain to injury. |
| format | Article |
| id | doaj-art-eea0aeb8506d45a59794f44a2493d596 |
| institution | Kabale University |
| issn | 2090-1852 2090-1860 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neurology Research International |
| spelling | doaj-art-eea0aeb8506d45a59794f44a2493d5962025-02-03T06:13:39ZengWileyNeurology Research International2090-18522090-18602012-01-01201210.1155/2012/102153102153Infection-Induced Vulnerability of Perinatal Brain InjuryCarina Mallard0Xiaoyang Wang1Department of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, P.O. Box 432, 40530 Göteborg, SwedenDepartment of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, P.O. Box 432, 40530 Göteborg, SwedenA growing body of evidence demonstrates that susceptibility and progression of both acute and chronic central nervous system disease in the newborn is closely associated with an innate immune response that can manifest from either direct infection and/or infection-triggered damage. A common feature of many of these diseases is the systemic exposure of the neonate to bacterial infections that elicit brain inflammation. In recent years, the importance of innate immune receptors in newborn brain injury, the so-called Toll-like receptors, has been demonstrated. In this paper we will discuss how neonatal sepsis, with particular emphasis on Escherichia coli, coagulase-negative staphylococci, and group B streptococcal infections in preterm infants, and Toll-like receptor-mediated inflammation can increase the vulnerability of the newborn brain to injury.http://dx.doi.org/10.1155/2012/102153 |
| spellingShingle | Carina Mallard Xiaoyang Wang Infection-Induced Vulnerability of Perinatal Brain Injury Neurology Research International |
| title | Infection-Induced Vulnerability of Perinatal Brain Injury |
| title_full | Infection-Induced Vulnerability of Perinatal Brain Injury |
| title_fullStr | Infection-Induced Vulnerability of Perinatal Brain Injury |
| title_full_unstemmed | Infection-Induced Vulnerability of Perinatal Brain Injury |
| title_short | Infection-Induced Vulnerability of Perinatal Brain Injury |
| title_sort | infection induced vulnerability of perinatal brain injury |
| url | http://dx.doi.org/10.1155/2012/102153 |
| work_keys_str_mv | AT carinamallard infectioninducedvulnerabilityofperinatalbraininjury AT xiaoyangwang infectioninducedvulnerabilityofperinatalbraininjury |