Cardiac‐peripheral transvenous gradients of microRNA expression in systolic heart failure patients
Abstract Aims The aims of the study are to assess the levels of coronary sinus (CS) miRNAs of systolic heart failure (HF) patients in samples obtained during cardiac resynchronization therapy (CRT) device implantation and compare them to the peripheral systemic venous miRNA expression. Methods and R...
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| Format: | Article |
| Language: | English |
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Wiley
2020-06-01
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| Series: | ESC Heart Failure |
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| Online Access: | https://doi.org/10.1002/ehf2.12597 |
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| author | Inbar Ben‐Zvi Natalia Volinsky Liza Grosman‐Rimon Izhak Haviv Guy Rozen Nizar Andria Nofar Asulin Nufar Margalit Ibrahim Marai Offer Amir |
| author_facet | Inbar Ben‐Zvi Natalia Volinsky Liza Grosman‐Rimon Izhak Haviv Guy Rozen Nizar Andria Nofar Asulin Nufar Margalit Ibrahim Marai Offer Amir |
| author_sort | Inbar Ben‐Zvi |
| collection | DOAJ |
| description | Abstract Aims The aims of the study are to assess the levels of coronary sinus (CS) miRNAs of systolic heart failure (HF) patients in samples obtained during cardiac resynchronization therapy (CRT) device implantation and compare them to the peripheral systemic venous miRNA expression. Methods and Results The cardiac specific miRNA levels were assessed in 60 patients, 39 HF patients with reduced ejection fraction and 21 control patients. The levels of four cardiac specified miRNAs (miR‐21‐5p, miR‐92b‐3p, miR‐125b‐5p, and miR‐133a‐3p) were compared between the peripheral samples of HF and controls and between peripheral venous in CS in the HF groups. Compared with controls, HF patients had higher peripheral serum venous levels of miR‐125b‐5p and miR‐133‐3p. In the HF group, the levels of expression were higher for miR‐125b‐5p and lower for miR‐92, and miR‐21‐5p in the CS, compared with the peripheral venous circulation. Conclusions The differences in miRNA expressions in CS compared with those in the periphery suggest that changes that may occur at the levels of the myocardial tissue in HF may be more relevant to our understanding of the biological linkage between miRNA expression and HF, than the traditional analysis of systemic serum miRNA expression. |
| format | Article |
| id | doaj-art-ee9e57a146804167be97354353180853 |
| institution | Kabale University |
| issn | 2055-5822 |
| language | English |
| publishDate | 2020-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | ESC Heart Failure |
| spelling | doaj-art-ee9e57a146804167be973543531808532025-02-03T10:25:46ZengWileyESC Heart Failure2055-58222020-06-017383584310.1002/ehf2.12597Cardiac‐peripheral transvenous gradients of microRNA expression in systolic heart failure patientsInbar Ben‐Zvi0Natalia Volinsky1Liza Grosman‐Rimon2Izhak Haviv3Guy Rozen4Nizar Andria5Nofar Asulin6Nufar Margalit7Ibrahim Marai8Offer Amir9Cardiovascular Department and Research Center Baruch Padeh Medical Center Tiberias IsraelCardiovascular Department and Research Center Baruch Padeh Medical Center Tiberias IsraelCardiovascular Department and Research Center Baruch Padeh Medical Center Tiberias IsraelThe Azrieli Faculty of Medicine in the Galilee Bar‐Ilan University Safed IsraelCardiovascular Department and Research Center Baruch Padeh Medical Center Tiberias IsraelCardiovascular Department and Research Center Baruch Padeh Medical Center Tiberias IsraelCardiovascular Department and Research Center Baruch Padeh Medical Center Tiberias IsraelCardiovascular Department and Research Center Baruch Padeh Medical Center Tiberias IsraelCardiovascular Department and Research Center Baruch Padeh Medical Center Tiberias IsraelCardiovascular Department and Research Center Baruch Padeh Medical Center Tiberias IsraelAbstract Aims The aims of the study are to assess the levels of coronary sinus (CS) miRNAs of systolic heart failure (HF) patients in samples obtained during cardiac resynchronization therapy (CRT) device implantation and compare them to the peripheral systemic venous miRNA expression. Methods and Results The cardiac specific miRNA levels were assessed in 60 patients, 39 HF patients with reduced ejection fraction and 21 control patients. The levels of four cardiac specified miRNAs (miR‐21‐5p, miR‐92b‐3p, miR‐125b‐5p, and miR‐133a‐3p) were compared between the peripheral samples of HF and controls and between peripheral venous in CS in the HF groups. Compared with controls, HF patients had higher peripheral serum venous levels of miR‐125b‐5p and miR‐133‐3p. In the HF group, the levels of expression were higher for miR‐125b‐5p and lower for miR‐92, and miR‐21‐5p in the CS, compared with the peripheral venous circulation. Conclusions The differences in miRNA expressions in CS compared with those in the periphery suggest that changes that may occur at the levels of the myocardial tissue in HF may be more relevant to our understanding of the biological linkage between miRNA expression and HF, than the traditional analysis of systemic serum miRNA expression.https://doi.org/10.1002/ehf2.12597Coronary SinusmiRNASystolic heart failure (HF)Cardiac resynchronization therapy |
| spellingShingle | Inbar Ben‐Zvi Natalia Volinsky Liza Grosman‐Rimon Izhak Haviv Guy Rozen Nizar Andria Nofar Asulin Nufar Margalit Ibrahim Marai Offer Amir Cardiac‐peripheral transvenous gradients of microRNA expression in systolic heart failure patients ESC Heart Failure Coronary Sinus miRNA Systolic heart failure (HF) Cardiac resynchronization therapy |
| title | Cardiac‐peripheral transvenous gradients of microRNA expression in systolic heart failure patients |
| title_full | Cardiac‐peripheral transvenous gradients of microRNA expression in systolic heart failure patients |
| title_fullStr | Cardiac‐peripheral transvenous gradients of microRNA expression in systolic heart failure patients |
| title_full_unstemmed | Cardiac‐peripheral transvenous gradients of microRNA expression in systolic heart failure patients |
| title_short | Cardiac‐peripheral transvenous gradients of microRNA expression in systolic heart failure patients |
| title_sort | cardiac peripheral transvenous gradients of microrna expression in systolic heart failure patients |
| topic | Coronary Sinus miRNA Systolic heart failure (HF) Cardiac resynchronization therapy |
| url | https://doi.org/10.1002/ehf2.12597 |
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