The Role of Hyperglycemia and Insulin Resistance in the Development and Progression of Pulmonary Arterial Hypertension
Pulmonary hypertension is a progressive disorder which often leads to right ventricular failure and death. While the existing classification system for pulmonary hypertension does not account for the impact of diabetes mellitus, evidence is emerging that suggests that diabetes is associated with pul...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/2481659 |
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| _version_ | 1832554926751875072 |
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| author | Daniel Grinnan Grant Farr Adam Fox Lori Sweeney |
| author_facet | Daniel Grinnan Grant Farr Adam Fox Lori Sweeney |
| author_sort | Daniel Grinnan |
| collection | DOAJ |
| description | Pulmonary hypertension is a progressive disorder which often leads to right ventricular failure and death. While the existing classification system for pulmonary hypertension does not account for the impact of diabetes mellitus, evidence is emerging that suggests that diabetes is associated with pulmonary hypertension and that diabetes modifies the course of pulmonary hypertension. There is also growing radiographic, hemodynamic, biochemical, and pathologic data supporting an association between diabetes and pulmonary hypertension. More robust epidemiologic studies are needed to confirm an association between diabetes and pulmonary hypertension and to show that diabetes is a disease modifier in pulmonary hypertension. In addition, evaluating the effects of glucose control in animals with pulmonary hypertension and diabetes (as well as in humans) is warranted. |
| format | Article |
| id | doaj-art-ee8ea08874e24502b0bf98ce07bf57f4 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-ee8ea08874e24502b0bf98ce07bf57f42025-02-03T05:50:11ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/24816592481659The Role of Hyperglycemia and Insulin Resistance in the Development and Progression of Pulmonary Arterial HypertensionDaniel Grinnan0Grant Farr1Adam Fox2Lori Sweeney3Division of Pulmonary and Critical Care Medicine, Virginia Commonwealth University Health System, Richmond, VA 23298, USADivision of Pulmonary and Critical Care Medicine, Virginia Commonwealth University Health System, Richmond, VA 23298, USADepartment of Internal Medicine, Virginia Commonwealth University Health System, Richmond, VA 23298, USADivision of Endocrinology, Virginia Commonwealth University Health System, Richmond, VA 23298, USAPulmonary hypertension is a progressive disorder which often leads to right ventricular failure and death. While the existing classification system for pulmonary hypertension does not account for the impact of diabetes mellitus, evidence is emerging that suggests that diabetes is associated with pulmonary hypertension and that diabetes modifies the course of pulmonary hypertension. There is also growing radiographic, hemodynamic, biochemical, and pathologic data supporting an association between diabetes and pulmonary hypertension. More robust epidemiologic studies are needed to confirm an association between diabetes and pulmonary hypertension and to show that diabetes is a disease modifier in pulmonary hypertension. In addition, evaluating the effects of glucose control in animals with pulmonary hypertension and diabetes (as well as in humans) is warranted.http://dx.doi.org/10.1155/2016/2481659 |
| spellingShingle | Daniel Grinnan Grant Farr Adam Fox Lori Sweeney The Role of Hyperglycemia and Insulin Resistance in the Development and Progression of Pulmonary Arterial Hypertension Journal of Diabetes Research |
| title | The Role of Hyperglycemia and Insulin Resistance in the Development and Progression of Pulmonary Arterial Hypertension |
| title_full | The Role of Hyperglycemia and Insulin Resistance in the Development and Progression of Pulmonary Arterial Hypertension |
| title_fullStr | The Role of Hyperglycemia and Insulin Resistance in the Development and Progression of Pulmonary Arterial Hypertension |
| title_full_unstemmed | The Role of Hyperglycemia and Insulin Resistance in the Development and Progression of Pulmonary Arterial Hypertension |
| title_short | The Role of Hyperglycemia and Insulin Resistance in the Development and Progression of Pulmonary Arterial Hypertension |
| title_sort | role of hyperglycemia and insulin resistance in the development and progression of pulmonary arterial hypertension |
| url | http://dx.doi.org/10.1155/2016/2481659 |
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