Impact of comorbid burden on global left cardiac function and prediction models for myocardial function damage: a cardiac magnetic resonance feature-tracking study
ObjectiveThis study aimed to explore the effects of comorbid burden on left cardiac myocardial function in patients without organic heart disease and to construct prediction models for myocardial function damage.MethodsA total of 82 healthy individuals and 198 patients with comorbid burden who had n...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1525334/full |
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| author | XiaoFeng Qu Miaomiao Bai Jianbo Lyu Lili Yin Jiahui Zhang Endong Zhao Lingjun Mei |
| author_facet | XiaoFeng Qu Miaomiao Bai Jianbo Lyu Lili Yin Jiahui Zhang Endong Zhao Lingjun Mei |
| author_sort | XiaoFeng Qu |
| collection | DOAJ |
| description | ObjectiveThis study aimed to explore the effects of comorbid burden on left cardiac myocardial function in patients without organic heart disease and to construct prediction models for myocardial function damage.MethodsA total of 82 healthy individuals and 198 patients with comorbid burden who had normal left ventricular ejection fraction (LVEF) were recruited. Comorbid burden included hypertension, type 2 diabetes mellitus (T2DM), and dyslipidemia. Based on the number of comorbidities, the patients were divided into two groups: comorbid burden <2 and comorbid burden ≥2. Cardiac magnetic resonance feature tracking (CMR-FT) was used to measure myocardial strain parameters.ResultsAfter adjustment, the left atrial (LA) reservoir strain (p = 0.011) and conduit strain (p < 0.001) were significantly lower in patients with a comorbid burden ≥2. The left ventricular (LV) global longitudinal strain (p < 0.001) and global radial strain (p = 0.010) were decreased in both the comorbid burden<2 and comorbid burden≥2 groups. The LV global circumferential strain (p = 0.006) was reduced in the comorbid burder≥2 group. Comorbid burden combined with male sex, postprandial blood glucose (PBG), and fasting blood glucose (FBG) proved to be excellent predictors of LV myocardial function damage (AUC = 0.848). In contrast, comorbid burden combined with male sex was only a fair predictor of LA myocardial function damage (AUC = 0.651).ConclusionCMR-FT can detect left-sided myocardial function damage in patients with comorbid burden but without organic heart disease prior to a decrease in LVEF. Comorbid burden combined with male sex, PBG, and FBG showed excellent predictive ability for LV myocardial function damage. Comorbid burden combined with the male sex showed a fair predictive ability for LA myocardial function damage. |
| format | Article |
| id | doaj-art-ee88b92d2008407189ef0fb0543a976f |
| institution | DOAJ |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj-art-ee88b92d2008407189ef0fb0543a976f2025-08-20T02:43:57ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-02-011210.3389/fmed.2025.15253341525334Impact of comorbid burden on global left cardiac function and prediction models for myocardial function damage: a cardiac magnetic resonance feature-tracking studyXiaoFeng Qu0Miaomiao Bai1Jianbo Lyu2Lili Yin3Jiahui Zhang4Endong Zhao5Lingjun Mei6Department of Radiology, The Second Hospital of Dalian Medical University, Dalian, ChinaDepartment of Radiology, The Second Hospital of Dalian Medical University, Dalian, ChinaDepartment of Radiology, The Second Hospital of Dalian Medical University, Dalian, ChinaDepartment of International Medical, The Second Hospital of Dalian Medical University, Dalian, ChinaDepartment of Radiology, The Second Hospital of Dalian Medical University, Dalian, ChinaDepartment of Radiology, The Second Hospital of Dalian Medical University, Dalian, ChinaDepartment of Radiology, The Second Hospital of Dalian Medical University, Dalian, ChinaObjectiveThis study aimed to explore the effects of comorbid burden on left cardiac myocardial function in patients without organic heart disease and to construct prediction models for myocardial function damage.MethodsA total of 82 healthy individuals and 198 patients with comorbid burden who had normal left ventricular ejection fraction (LVEF) were recruited. Comorbid burden included hypertension, type 2 diabetes mellitus (T2DM), and dyslipidemia. Based on the number of comorbidities, the patients were divided into two groups: comorbid burden <2 and comorbid burden ≥2. Cardiac magnetic resonance feature tracking (CMR-FT) was used to measure myocardial strain parameters.ResultsAfter adjustment, the left atrial (LA) reservoir strain (p = 0.011) and conduit strain (p < 0.001) were significantly lower in patients with a comorbid burden ≥2. The left ventricular (LV) global longitudinal strain (p < 0.001) and global radial strain (p = 0.010) were decreased in both the comorbid burden<2 and comorbid burden≥2 groups. The LV global circumferential strain (p = 0.006) was reduced in the comorbid burder≥2 group. Comorbid burden combined with male sex, postprandial blood glucose (PBG), and fasting blood glucose (FBG) proved to be excellent predictors of LV myocardial function damage (AUC = 0.848). In contrast, comorbid burden combined with male sex was only a fair predictor of LA myocardial function damage (AUC = 0.651).ConclusionCMR-FT can detect left-sided myocardial function damage in patients with comorbid burden but without organic heart disease prior to a decrease in LVEF. Comorbid burden combined with male sex, PBG, and FBG showed excellent predictive ability for LV myocardial function damage. Comorbid burden combined with the male sex showed a fair predictive ability for LA myocardial function damage.https://www.frontiersin.org/articles/10.3389/fmed.2025.1525334/fullCMR-FTcomorbid burdenmyocardial function damagemyocardial strainhypertensiontype 2 diabetes mellitus |
| spellingShingle | XiaoFeng Qu Miaomiao Bai Jianbo Lyu Lili Yin Jiahui Zhang Endong Zhao Lingjun Mei Impact of comorbid burden on global left cardiac function and prediction models for myocardial function damage: a cardiac magnetic resonance feature-tracking study Frontiers in Medicine CMR-FT comorbid burden myocardial function damage myocardial strain hypertension type 2 diabetes mellitus |
| title | Impact of comorbid burden on global left cardiac function and prediction models for myocardial function damage: a cardiac magnetic resonance feature-tracking study |
| title_full | Impact of comorbid burden on global left cardiac function and prediction models for myocardial function damage: a cardiac magnetic resonance feature-tracking study |
| title_fullStr | Impact of comorbid burden on global left cardiac function and prediction models for myocardial function damage: a cardiac magnetic resonance feature-tracking study |
| title_full_unstemmed | Impact of comorbid burden on global left cardiac function and prediction models for myocardial function damage: a cardiac magnetic resonance feature-tracking study |
| title_short | Impact of comorbid burden on global left cardiac function and prediction models for myocardial function damage: a cardiac magnetic resonance feature-tracking study |
| title_sort | impact of comorbid burden on global left cardiac function and prediction models for myocardial function damage a cardiac magnetic resonance feature tracking study |
| topic | CMR-FT comorbid burden myocardial function damage myocardial strain hypertension type 2 diabetes mellitus |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1525334/full |
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