The therapeutic effects of probiotics on core and associated behavioral symptoms of autism spectrum disorders: a systematic review and meta-analysis
Abstract Background We aimed at investigating the efficacies of probiotics in alleviating the core and associated symptoms of autism spectrum disorder (ASD). Methods Randomized placebo-controlled trials were identified from major electronic databases from inception to Nov 2023. The outcomes of inter...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-12-01
|
| Series: | Child and Adolescent Psychiatry and Mental Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13034-024-00848-3 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850134040833687552 |
|---|---|
| author | Jen-Chin Lee Chia-Min Chen Cheuk-Kwan Sun I-Ting Tsai Yu-Shian Cheng Hsien-Jane Chiu Ming Yu Wang Yen-Hsiang Tang Kuo-Chuan Hung |
| author_facet | Jen-Chin Lee Chia-Min Chen Cheuk-Kwan Sun I-Ting Tsai Yu-Shian Cheng Hsien-Jane Chiu Ming Yu Wang Yen-Hsiang Tang Kuo-Chuan Hung |
| author_sort | Jen-Chin Lee |
| collection | DOAJ |
| description | Abstract Background We aimed at investigating the efficacies of probiotics in alleviating the core and associated symptoms of autism spectrum disorder (ASD). Methods Randomized placebo-controlled trials were identified from major electronic databases from inception to Nov 2023. The outcomes of interests including improvements in the total and associated symptoms of ASD were quantitatively expressed as effect size (ES) based on standardized mean difference (SMD) with 95% confidence interval (CI). Results Ten studies with 522 participants (mean age = 8.11) were included in this meta-analysis. The primary results revealed significant improvement in total symptoms in the probiotics group compared with the controls (SMD = − 0.19, p = 0.03, ten studies, n = 522) but not the core symptoms (i.e., repetitive restricted behaviors, As affiliations 3 and 5 are same, we have deleted the duplicate affiliations and renumbered accordingly. Please check and confirm.problems with social behaviors/communication). Subgroup analyses demonstrated improvement in total symptoms in probiotics users relative to their controls only in studies using multiple-strain probiotics (SMD = − 0.26, p = 0.03, five studies, n = 288) but not studies using single-strain regimens. Secondary results showed improvement in adaptation (SMD = 0.37, p = 0.03, three studies, n = 139) and an improvement trend in anxiety symptoms in the probiotics group compared with controls (SMD = − 0.29, 95% CI − 0.60 to 0.02, p = 0.07, three studies, n = 163) but failed to demonstrate greater improvement in the former regarding symptoms of irritability/aggression, hyperactivity/impulsivity, inattention, and parental stress. Conclusions Our study supported probiotics use against the overall behavioral symptoms of ASD, mainly in individuals receiving multiple-strain probiotics as supplements. However, our results showed that probiotics use was only associated with improvement in adaptation and perhaps anxiety, but not core symptoms, highlighting the impact of adaptation on quality of life rather than just the core symptoms. Nevertheless, the limited number of included trials warrants further large-scale clinical investigations. |
| format | Article |
| id | doaj-art-ee8757805104449fa4e2319e8bee749c |
| institution | OA Journals |
| issn | 1753-2000 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Child and Adolescent Psychiatry and Mental Health |
| spelling | doaj-art-ee8757805104449fa4e2319e8bee749c2025-08-20T02:31:48ZengBMCChild and Adolescent Psychiatry and Mental Health1753-20002024-12-0118111310.1186/s13034-024-00848-3The therapeutic effects of probiotics on core and associated behavioral symptoms of autism spectrum disorders: a systematic review and meta-analysisJen-Chin Lee0Chia-Min Chen1Cheuk-Kwan Sun2I-Ting Tsai3Yu-Shian Cheng4Hsien-Jane Chiu5Ming Yu Wang6Yen-Hsiang Tang7Kuo-Chuan Hung8Department of General Psychiatry, Taoyuan Psychiatric Center, Ministry of Health and WelfareDepartment of Natural Biotechnology, Nanhua UniversityDepartment of Emergency Medicine, E-Da Dachang Hospital, I-Shou UniversityDepartment of Emergency Medicine, E-Da Dachang Hospital, I-Shou UniversityDepartment of Psychiatry, Tsyr-Huey Mental Hospital, Kaohsiung Jen-Ai’s HomeDepartment of General Psychiatry, Taoyuan Psychiatric Center, Ministry of Health and WelfareDepartment of Psychiatry, China Medical University Hsinchu Hospital, China Medical UniversityDepartment of Critical Care Medicine, MacKay Memorial HospitalDepartment of Anesthesiology, Chi Mei Medical CenterAbstract Background We aimed at investigating the efficacies of probiotics in alleviating the core and associated symptoms of autism spectrum disorder (ASD). Methods Randomized placebo-controlled trials were identified from major electronic databases from inception to Nov 2023. The outcomes of interests including improvements in the total and associated symptoms of ASD were quantitatively expressed as effect size (ES) based on standardized mean difference (SMD) with 95% confidence interval (CI). Results Ten studies with 522 participants (mean age = 8.11) were included in this meta-analysis. The primary results revealed significant improvement in total symptoms in the probiotics group compared with the controls (SMD = − 0.19, p = 0.03, ten studies, n = 522) but not the core symptoms (i.e., repetitive restricted behaviors, As affiliations 3 and 5 are same, we have deleted the duplicate affiliations and renumbered accordingly. Please check and confirm.problems with social behaviors/communication). Subgroup analyses demonstrated improvement in total symptoms in probiotics users relative to their controls only in studies using multiple-strain probiotics (SMD = − 0.26, p = 0.03, five studies, n = 288) but not studies using single-strain regimens. Secondary results showed improvement in adaptation (SMD = 0.37, p = 0.03, three studies, n = 139) and an improvement trend in anxiety symptoms in the probiotics group compared with controls (SMD = − 0.29, 95% CI − 0.60 to 0.02, p = 0.07, three studies, n = 163) but failed to demonstrate greater improvement in the former regarding symptoms of irritability/aggression, hyperactivity/impulsivity, inattention, and parental stress. Conclusions Our study supported probiotics use against the overall behavioral symptoms of ASD, mainly in individuals receiving multiple-strain probiotics as supplements. However, our results showed that probiotics use was only associated with improvement in adaptation and perhaps anxiety, but not core symptoms, highlighting the impact of adaptation on quality of life rather than just the core symptoms. Nevertheless, the limited number of included trials warrants further large-scale clinical investigations.https://doi.org/10.1186/s13034-024-00848-3ProbioticsAutism spectrum disorderAnd meta-analysis |
| spellingShingle | Jen-Chin Lee Chia-Min Chen Cheuk-Kwan Sun I-Ting Tsai Yu-Shian Cheng Hsien-Jane Chiu Ming Yu Wang Yen-Hsiang Tang Kuo-Chuan Hung The therapeutic effects of probiotics on core and associated behavioral symptoms of autism spectrum disorders: a systematic review and meta-analysis Child and Adolescent Psychiatry and Mental Health Probiotics Autism spectrum disorder And meta-analysis |
| title | The therapeutic effects of probiotics on core and associated behavioral symptoms of autism spectrum disorders: a systematic review and meta-analysis |
| title_full | The therapeutic effects of probiotics on core and associated behavioral symptoms of autism spectrum disorders: a systematic review and meta-analysis |
| title_fullStr | The therapeutic effects of probiotics on core and associated behavioral symptoms of autism spectrum disorders: a systematic review and meta-analysis |
| title_full_unstemmed | The therapeutic effects of probiotics on core and associated behavioral symptoms of autism spectrum disorders: a systematic review and meta-analysis |
| title_short | The therapeutic effects of probiotics on core and associated behavioral symptoms of autism spectrum disorders: a systematic review and meta-analysis |
| title_sort | therapeutic effects of probiotics on core and associated behavioral symptoms of autism spectrum disorders a systematic review and meta analysis |
| topic | Probiotics Autism spectrum disorder And meta-analysis |
| url | https://doi.org/10.1186/s13034-024-00848-3 |
| work_keys_str_mv | AT jenchinlee thetherapeuticeffectsofprobioticsoncoreandassociatedbehavioralsymptomsofautismspectrumdisordersasystematicreviewandmetaanalysis AT chiaminchen thetherapeuticeffectsofprobioticsoncoreandassociatedbehavioralsymptomsofautismspectrumdisordersasystematicreviewandmetaanalysis AT cheukkwansun thetherapeuticeffectsofprobioticsoncoreandassociatedbehavioralsymptomsofautismspectrumdisordersasystematicreviewandmetaanalysis AT itingtsai thetherapeuticeffectsofprobioticsoncoreandassociatedbehavioralsymptomsofautismspectrumdisordersasystematicreviewandmetaanalysis AT yushiancheng thetherapeuticeffectsofprobioticsoncoreandassociatedbehavioralsymptomsofautismspectrumdisordersasystematicreviewandmetaanalysis AT hsienjanechiu thetherapeuticeffectsofprobioticsoncoreandassociatedbehavioralsymptomsofautismspectrumdisordersasystematicreviewandmetaanalysis AT mingyuwang thetherapeuticeffectsofprobioticsoncoreandassociatedbehavioralsymptomsofautismspectrumdisordersasystematicreviewandmetaanalysis AT yenhsiangtang thetherapeuticeffectsofprobioticsoncoreandassociatedbehavioralsymptomsofautismspectrumdisordersasystematicreviewandmetaanalysis AT kuochuanhung thetherapeuticeffectsofprobioticsoncoreandassociatedbehavioralsymptomsofautismspectrumdisordersasystematicreviewandmetaanalysis AT jenchinlee therapeuticeffectsofprobioticsoncoreandassociatedbehavioralsymptomsofautismspectrumdisordersasystematicreviewandmetaanalysis AT chiaminchen therapeuticeffectsofprobioticsoncoreandassociatedbehavioralsymptomsofautismspectrumdisordersasystematicreviewandmetaanalysis AT cheukkwansun therapeuticeffectsofprobioticsoncoreandassociatedbehavioralsymptomsofautismspectrumdisordersasystematicreviewandmetaanalysis AT itingtsai therapeuticeffectsofprobioticsoncoreandassociatedbehavioralsymptomsofautismspectrumdisordersasystematicreviewandmetaanalysis AT yushiancheng therapeuticeffectsofprobioticsoncoreandassociatedbehavioralsymptomsofautismspectrumdisordersasystematicreviewandmetaanalysis AT hsienjanechiu therapeuticeffectsofprobioticsoncoreandassociatedbehavioralsymptomsofautismspectrumdisordersasystematicreviewandmetaanalysis AT mingyuwang therapeuticeffectsofprobioticsoncoreandassociatedbehavioralsymptomsofautismspectrumdisordersasystematicreviewandmetaanalysis AT yenhsiangtang therapeuticeffectsofprobioticsoncoreandassociatedbehavioralsymptomsofautismspectrumdisordersasystematicreviewandmetaanalysis AT kuochuanhung therapeuticeffectsofprobioticsoncoreandassociatedbehavioralsymptomsofautismspectrumdisordersasystematicreviewandmetaanalysis |