De novo gastric cancer developing after liver transplantation from deceased donor for biliary atresia: a case report
Abstract Background Apart from Kasai’s procedure, liver transplantation (LTx) has dramatically improved the outcome of children with biliary atresia (BA). However, de novo malignancy has been reported to be one of the major causes of late mortality after LTx among adults. We report a rare case of de...
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| Format: | Article |
| Language: | English |
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Japan Surgical Society
2021-05-01
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| Series: | Surgical Case Reports |
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| Online Access: | https://doi.org/10.1186/s40792-021-01210-x |
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| author | Naruki Higashidate Suguru Fukahori Shinji Ishii Nobuyuki Saikusa Naoki Hashizume Yoshinori Koga Daisuke Masui Saki Sakamoto Shiori Tsuruhisa Hirotomo Nakahara Yoshiaki Tanaka Masaru Fukahori Keisuke Miwa Yoshiki Naito Minoru Yagi |
| author_facet | Naruki Higashidate Suguru Fukahori Shinji Ishii Nobuyuki Saikusa Naoki Hashizume Yoshinori Koga Daisuke Masui Saki Sakamoto Shiori Tsuruhisa Hirotomo Nakahara Yoshiaki Tanaka Masaru Fukahori Keisuke Miwa Yoshiki Naito Minoru Yagi |
| author_sort | Naruki Higashidate |
| collection | DOAJ |
| description | Abstract Background Apart from Kasai’s procedure, liver transplantation (LTx) has dramatically improved the outcome of children with biliary atresia (BA). However, de novo malignancy has been reported to be one of the major causes of late mortality after LTx among adults. We report a rare case of de novo gastric cancer developing after LTx for BA received during childhood. Case presentation A 21-year-old male patient who had undergone LTx for BA at age 2 years occasionally visited our outpatient clinic due to symptoms of epigastric pain and dysphagia. Endoscopic examination and computed tomography revealed advanced gastric cancer at the gastroesophageal junction with multiple liver metastases. Despite systemic chemotherapy, the disease progressed, resulting in patient’s death 2 years after the diagnosis. Conclusions De novo malignancy in the absence of post-transplant lymphoproliferative disease is rare in pediatric patients who received LTx. To the best of our knowledge, no report has been available on the development of gastric cancer after LTx for BA during childhood. Primary physicians should therefore establish a follow-up plan for patients receiving LTx for BA considering the potential for the development of de novo malignancy, including gastric cancer, despite its rarity. |
| format | Article |
| id | doaj-art-ee856017800144bc8b9f4760b5fb02b4 |
| institution | Kabale University |
| issn | 2198-7793 |
| language | English |
| publishDate | 2021-05-01 |
| publisher | Japan Surgical Society |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj-art-ee856017800144bc8b9f4760b5fb02b42025-08-20T03:39:09ZengJapan Surgical SocietySurgical Case Reports2198-77932021-05-01711510.1186/s40792-021-01210-xDe novo gastric cancer developing after liver transplantation from deceased donor for biliary atresia: a case reportNaruki Higashidate0Suguru Fukahori1Shinji Ishii2Nobuyuki Saikusa3Naoki Hashizume4Yoshinori Koga5Daisuke Masui6Saki Sakamoto7Shiori Tsuruhisa8Hirotomo Nakahara9Yoshiaki Tanaka10Masaru Fukahori11Keisuke Miwa12Yoshiki Naito13Minoru Yagi14Department of Pediatric Surgery, Kurume University School of MedicineDepartment of Pediatric Surgery, Kurume University School of MedicineDepartment of Pediatric Surgery, Kurume University School of MedicineDepartment of Pediatric Surgery, Kurume University School of MedicineDepartment of Pediatric Surgery, Kurume University School of MedicineDepartment of Pediatric Surgery, Kurume University School of MedicineDepartment of Pediatric Surgery, Kurume University School of MedicineDepartment of Pediatric Surgery, Kurume University School of MedicineDepartment of Pediatric Surgery, Kurume University School of MedicineDepartment of Pediatric Surgery, Kurume University School of MedicineDivision of Medical Safety Management, Kurume University HospitalMultidisciplinary Cancer Treatment Center, Kurume University HospitalMultidisciplinary Cancer Treatment Center, Kurume University HospitalDepartment of Diagnostic Pathology, Kurume University HospitalDepartment of Pediatric Surgery, Kurume University School of MedicineAbstract Background Apart from Kasai’s procedure, liver transplantation (LTx) has dramatically improved the outcome of children with biliary atresia (BA). However, de novo malignancy has been reported to be one of the major causes of late mortality after LTx among adults. We report a rare case of de novo gastric cancer developing after LTx for BA received during childhood. Case presentation A 21-year-old male patient who had undergone LTx for BA at age 2 years occasionally visited our outpatient clinic due to symptoms of epigastric pain and dysphagia. Endoscopic examination and computed tomography revealed advanced gastric cancer at the gastroesophageal junction with multiple liver metastases. Despite systemic chemotherapy, the disease progressed, resulting in patient’s death 2 years after the diagnosis. Conclusions De novo malignancy in the absence of post-transplant lymphoproliferative disease is rare in pediatric patients who received LTx. To the best of our knowledge, no report has been available on the development of gastric cancer after LTx for BA during childhood. Primary physicians should therefore establish a follow-up plan for patients receiving LTx for BA considering the potential for the development of de novo malignancy, including gastric cancer, despite its rarity.https://doi.org/10.1186/s40792-021-01210-xBiliary atresiaLiver transplantationDe novo malignancyGastric cancer |
| spellingShingle | Naruki Higashidate Suguru Fukahori Shinji Ishii Nobuyuki Saikusa Naoki Hashizume Yoshinori Koga Daisuke Masui Saki Sakamoto Shiori Tsuruhisa Hirotomo Nakahara Yoshiaki Tanaka Masaru Fukahori Keisuke Miwa Yoshiki Naito Minoru Yagi De novo gastric cancer developing after liver transplantation from deceased donor for biliary atresia: a case report Surgical Case Reports Biliary atresia Liver transplantation De novo malignancy Gastric cancer |
| title | De novo gastric cancer developing after liver transplantation from deceased donor for biliary atresia: a case report |
| title_full | De novo gastric cancer developing after liver transplantation from deceased donor for biliary atresia: a case report |
| title_fullStr | De novo gastric cancer developing after liver transplantation from deceased donor for biliary atresia: a case report |
| title_full_unstemmed | De novo gastric cancer developing after liver transplantation from deceased donor for biliary atresia: a case report |
| title_short | De novo gastric cancer developing after liver transplantation from deceased donor for biliary atresia: a case report |
| title_sort | de novo gastric cancer developing after liver transplantation from deceased donor for biliary atresia a case report |
| topic | Biliary atresia Liver transplantation De novo malignancy Gastric cancer |
| url | https://doi.org/10.1186/s40792-021-01210-x |
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