Aerobic exercise-induced changes in fluid biomarkers in Parkinson’s disease
Abstract Parkinson’s disease (PD) is a neurodegenerative disease characterized by motor and non-motor symptoms that progressively deteriorate and for which there is no disease-modifying pharmacological treatment. Exercise is widely recommended for individuals with PD due to its potential neuroprotec...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-07-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-025-01042-8 |
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| author | Nijee S. Luthra Niyati Mehta Miranda J. Munoz Giamila Fantuzzi Guillaume Lamotte Jacob M. Haus Nikolaus R. McFarland Malú G. Tansey Paulina Gonzalez-Latapi Gabriela Caraveo Un Jung Kang Daniel M. Corcos |
| author_facet | Nijee S. Luthra Niyati Mehta Miranda J. Munoz Giamila Fantuzzi Guillaume Lamotte Jacob M. Haus Nikolaus R. McFarland Malú G. Tansey Paulina Gonzalez-Latapi Gabriela Caraveo Un Jung Kang Daniel M. Corcos |
| author_sort | Nijee S. Luthra |
| collection | DOAJ |
| description | Abstract Parkinson’s disease (PD) is a neurodegenerative disease characterized by motor and non-motor symptoms that progressively deteriorate and for which there is no disease-modifying pharmacological treatment. Exercise is widely recommended for individuals with PD due to its potential neuroprotective benefits. However, the mechanisms underlying these exercise-induced effects in PD remain poorly understood. Analyzing fluid biomarkers responsive to exercise could offer valuable insights into the mechanisms by which exercise impacts PD and aid in optimizing exercise prescriptions for individuals with PD. This review explores exercise-responsive biomarkers categorized into three key groups—neurotrophic, inflammatory, and neuroendocrine markers. It highlights both well-validated biomarkers and candidates with promising potential. We also highlight key biomarkers linked to PD pathology, such as α-synuclein, and their potential connection to exercise based on current evidence. Comprehensive characterization of these biomarkers will advance our understanding of the biological effects of exercise in PD, enabling mechanism-based and objective measures to evaluate exercise response in future clinical trials and its impact on PD signs and symptoms. |
| format | Article |
| id | doaj-art-ee80dc9a51f74643853312c9f88f5f64 |
| institution | DOAJ |
| issn | 2373-8057 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj-art-ee80dc9a51f74643853312c9f88f5f642025-08-20T03:03:32ZengNature Portfolionpj Parkinson's Disease2373-80572025-07-0111112110.1038/s41531-025-01042-8Aerobic exercise-induced changes in fluid biomarkers in Parkinson’s diseaseNijee S. Luthra0Niyati Mehta1Miranda J. Munoz2Giamila Fantuzzi3Guillaume Lamotte4Jacob M. Haus5Nikolaus R. McFarland6Malú G. Tansey7Paulina Gonzalez-Latapi8Gabriela Caraveo9Un Jung Kang10Daniel M. Corcos11Department of Neurology, University of California San FranciscoDepartment of Physical Therapy and Human Movement Sciences, Northwestern UniversityDepartment of Physical Therapy and Human Movement Sciences, Northwestern UniversityDepartment of Kinesiology and Nutrition, University of Illinois at ChicagoDepartment of Neurology, University of UtahSchool of Kinesiology, University of MichiganDepartment of Neurology, University of FloridaStark Neuroscience Research Institute, Indiana University School of MedicineDepartment of Neurology, Northwestern UniversityDepartment of Neurology, Northwestern UniversityDepartments of Neurology and Neuroscience, NYU Grossman School of MedicineDepartment of Physical Therapy and Human Movement Sciences, Northwestern UniversityAbstract Parkinson’s disease (PD) is a neurodegenerative disease characterized by motor and non-motor symptoms that progressively deteriorate and for which there is no disease-modifying pharmacological treatment. Exercise is widely recommended for individuals with PD due to its potential neuroprotective benefits. However, the mechanisms underlying these exercise-induced effects in PD remain poorly understood. Analyzing fluid biomarkers responsive to exercise could offer valuable insights into the mechanisms by which exercise impacts PD and aid in optimizing exercise prescriptions for individuals with PD. This review explores exercise-responsive biomarkers categorized into three key groups—neurotrophic, inflammatory, and neuroendocrine markers. It highlights both well-validated biomarkers and candidates with promising potential. We also highlight key biomarkers linked to PD pathology, such as α-synuclein, and their potential connection to exercise based on current evidence. Comprehensive characterization of these biomarkers will advance our understanding of the biological effects of exercise in PD, enabling mechanism-based and objective measures to evaluate exercise response in future clinical trials and its impact on PD signs and symptoms.https://doi.org/10.1038/s41531-025-01042-8 |
| spellingShingle | Nijee S. Luthra Niyati Mehta Miranda J. Munoz Giamila Fantuzzi Guillaume Lamotte Jacob M. Haus Nikolaus R. McFarland Malú G. Tansey Paulina Gonzalez-Latapi Gabriela Caraveo Un Jung Kang Daniel M. Corcos Aerobic exercise-induced changes in fluid biomarkers in Parkinson’s disease npj Parkinson's Disease |
| title | Aerobic exercise-induced changes in fluid biomarkers in Parkinson’s disease |
| title_full | Aerobic exercise-induced changes in fluid biomarkers in Parkinson’s disease |
| title_fullStr | Aerobic exercise-induced changes in fluid biomarkers in Parkinson’s disease |
| title_full_unstemmed | Aerobic exercise-induced changes in fluid biomarkers in Parkinson’s disease |
| title_short | Aerobic exercise-induced changes in fluid biomarkers in Parkinson’s disease |
| title_sort | aerobic exercise induced changes in fluid biomarkers in parkinson s disease |
| url | https://doi.org/10.1038/s41531-025-01042-8 |
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