Cell Reprogramming, IPS Limitations, and Overcoming Strategies in Dental Bioengineering
The procurement of induced pluripotent stem cells, or IPS cells, from adult differentiated animal cells has the potential to revolutionize future medicine, where reprogrammed IPS cells may be used to repair disease-affected tissues on demand. The potential of IPS cell technology is tremendous, but i...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2012/365932 |
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| _version_ | 1832560356857217024 |
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| author | Gaskon Ibarretxe Antonia Alvarez Maria-Luz Cañavate Enrique Hilario Maitane Aurrekoetxea Fernando Unda |
| author_facet | Gaskon Ibarretxe Antonia Alvarez Maria-Luz Cañavate Enrique Hilario Maitane Aurrekoetxea Fernando Unda |
| author_sort | Gaskon Ibarretxe |
| collection | DOAJ |
| description | The procurement of induced pluripotent stem cells, or IPS cells, from adult differentiated animal cells has the potential to revolutionize future medicine, where reprogrammed IPS cells may be used to repair disease-affected tissues on demand. The potential of IPS cell technology is tremendous, but it will be essential to improve the methodologies for IPS cell generation and to precisely evaluate each clone and subclone of IPS cells for their safety and efficacy. Additionally, the current state of knowledge on IPS cells advises that research on their regenerative properties is carried out in appropriate tissue and organ systems that permit a safe assessment of the long-term behavior of these reprogrammed cells. In the present paper, we discuss the mechanisms of cell reprogramming, current technical limitations of IPS cells for their use in human tissue engineering, and possibilities to overcome them in the particular case of dental regeneration. |
| format | Article |
| id | doaj-art-ee7f8a61324b4c25b197cd47e82f5331 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-ee7f8a61324b4c25b197cd47e82f53312025-02-03T01:27:49ZengWileyStem Cells International1687-966X1687-96782012-01-01201210.1155/2012/365932365932Cell Reprogramming, IPS Limitations, and Overcoming Strategies in Dental BioengineeringGaskon Ibarretxe0Antonia Alvarez1Maria-Luz Cañavate2Enrique Hilario3Maitane Aurrekoetxea4Fernando Unda5Department of Cell Biology and Histology, Faculty of Medicine and Dentistry, University of the Basque Country (UPV/EHU), 48940 Leioa, SpainDepartment of Cell Biology and Histology, Faculty of Medicine and Dentistry, University of the Basque Country (UPV/EHU), 48940 Leioa, SpainDepartment of Cell Biology and Histology, Faculty of Medicine and Dentistry, University of the Basque Country (UPV/EHU), 48940 Leioa, SpainDepartment of Cell Biology and Histology, Faculty of Medicine and Dentistry, University of the Basque Country (UPV/EHU), 48940 Leioa, SpainDepartment of Cell Biology and Histology, Faculty of Medicine and Dentistry, University of the Basque Country (UPV/EHU), 48940 Leioa, SpainDepartment of Cell Biology and Histology, Faculty of Medicine and Dentistry, University of the Basque Country (UPV/EHU), 48940 Leioa, SpainThe procurement of induced pluripotent stem cells, or IPS cells, from adult differentiated animal cells has the potential to revolutionize future medicine, where reprogrammed IPS cells may be used to repair disease-affected tissues on demand. The potential of IPS cell technology is tremendous, but it will be essential to improve the methodologies for IPS cell generation and to precisely evaluate each clone and subclone of IPS cells for their safety and efficacy. Additionally, the current state of knowledge on IPS cells advises that research on their regenerative properties is carried out in appropriate tissue and organ systems that permit a safe assessment of the long-term behavior of these reprogrammed cells. In the present paper, we discuss the mechanisms of cell reprogramming, current technical limitations of IPS cells for their use in human tissue engineering, and possibilities to overcome them in the particular case of dental regeneration.http://dx.doi.org/10.1155/2012/365932 |
| spellingShingle | Gaskon Ibarretxe Antonia Alvarez Maria-Luz Cañavate Enrique Hilario Maitane Aurrekoetxea Fernando Unda Cell Reprogramming, IPS Limitations, and Overcoming Strategies in Dental Bioengineering Stem Cells International |
| title | Cell Reprogramming, IPS Limitations, and Overcoming Strategies in Dental Bioengineering |
| title_full | Cell Reprogramming, IPS Limitations, and Overcoming Strategies in Dental Bioengineering |
| title_fullStr | Cell Reprogramming, IPS Limitations, and Overcoming Strategies in Dental Bioengineering |
| title_full_unstemmed | Cell Reprogramming, IPS Limitations, and Overcoming Strategies in Dental Bioengineering |
| title_short | Cell Reprogramming, IPS Limitations, and Overcoming Strategies in Dental Bioengineering |
| title_sort | cell reprogramming ips limitations and overcoming strategies in dental bioengineering |
| url | http://dx.doi.org/10.1155/2012/365932 |
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