A Feedback Loop Driven by H4K12 Lactylation and HDAC3 in Macrophages Regulates Lactate‐Induced Collagen Synthesis in Fibroblasts Via the TGF‐β Signaling

A Feedback Loop Driven by H4K12 Lactylation and HDAC3 in Macrophages Regulates Lactate‐Induced Collagen Synthesis in Fibroblasts Via the TGF‐β Signaling

Abstract The decrease in fibroblast collagen is a primary contributor to skin aging. Lactate can participate in collagen synthesis through lysine lactylation by regulating gene transcription. However, the precise mechanism by which lactate influences collagen synthesis requires further investigation...

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Bibliographic Details
Main Authors: Ying Zou, Mibu Cao, Meiling Tai, Haoxian Zhou, Li Tao, Shu Wu, Kaiye Yang, Youliang Zhang, Yuanlong Ge, Hao Wang, Shengkang Luo, Zhenyu Ju
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Advanced Science
Subjects:
collagen synthesis
fibroblasts
H4K12 lactylation
lactate
macrophages
Online Access:https://doi.org/10.1002/advs.202411408
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