Further In Vitro and Ex Vivo Pharmacological and Kinetic Characterizations of CCF219B: A Positive Allosteric Modulator of the α<sub>1A</sub>-Adrenergic Receptor

Further In Vitro and Ex Vivo Pharmacological and Kinetic Characterizations of CCF219B: A Positive Allosteric Modulator of the α<sub>1A</sub>-Adrenergic Receptor

<b>Background:</b> Alterations in the adrenergic system have been associated with the pathophysiology of Alzheimer’s disease (AD). A novel α<sub>1A</sub>-adrenergic receptor (AR)-positive allosteric modulator (PAM), CCF219B, has been shown to outperform donepezil with rescue...

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Bibliographic Details
Main Authors: Robert S. Papay, Dianne M. Perez
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Pharmaceuticals
Subjects:
Alzheimer’s disease
adrenergic receptor
GPCR
allosteric modulator
kinetics
Online Access:https://www.mdpi.com/1424-8247/18/4/476
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