An Overview of the Skin Microbiome, the Potential for Pathogen Shift, and Dysbiosis in Common Skin Pathologies
Recent interest in the diverse ecosystem of bacteria, fungi, parasites, and viruses that make up the skin microbiome has led to several studies investigating the microbiome in healthy skin and in a variety of dermatological conditions. An imbalance of the normal skin flora can cause some skin diseas...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/13/1/54 |
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| author | Anita Smith Roberta Dumbrava Noor-Ul-Huda Ghori Rachael Foster James Campbell Andrew Duthie Gerard Hoyne Marius Rademaker Asha C. Bowen |
| author_facet | Anita Smith Roberta Dumbrava Noor-Ul-Huda Ghori Rachael Foster James Campbell Andrew Duthie Gerard Hoyne Marius Rademaker Asha C. Bowen |
| author_sort | Anita Smith |
| collection | DOAJ |
| description | Recent interest in the diverse ecosystem of bacteria, fungi, parasites, and viruses that make up the skin microbiome has led to several studies investigating the microbiome in healthy skin and in a variety of dermatological conditions. An imbalance of the normal skin flora can cause some skin diseases, and current culture techniques are often unable to detect a microorganism to further our understanding of the clinical–microbiological correlates of disease and dysbiosis. Atopic dermatitis and rosacea are presentations that GPs often manage that may have an infective or microbiological component and can be challenging to treat. We aim to discuss the implications of the skin microbiome including the impact of dysbiosis on conditions such as these. We will also discuss some clinical pearls for initial and future directions of the management of conditions such as atopic dermatitis, rosacea, and hidradenitis suppurativa. Further research using culture-independent techniques is needed for conditions involving microbial dysbiosis to advance our knowledge of skin disease pathophysiology and guide future management. |
| format | Article |
| id | doaj-art-ee793a0109e24b13998282e730727326 |
| institution | Kabale University |
| issn | 2076-2607 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj-art-ee793a0109e24b13998282e7307273262025-01-24T13:42:27ZengMDPI AGMicroorganisms2076-26072025-01-011315410.3390/microorganisms13010054An Overview of the Skin Microbiome, the Potential for Pathogen Shift, and Dysbiosis in Common Skin PathologiesAnita Smith0Roberta Dumbrava1Noor-Ul-Huda Ghori2Rachael Foster3James Campbell4Andrew Duthie5Gerard Hoyne6Marius Rademaker7Asha C. Bowen8Healthy Skin Team, Wesfarmers Centre of Vaccines and Infectious Diseases, The Kids Research Institute Australia, Perth, WA 6009, AustraliaSir Charles Gairdner Hospital, Perth, WA 6009, AustraliaHealthy Skin Team, Wesfarmers Centre of Vaccines and Infectious Diseases, The Kids Research Institute Australia, Perth, WA 6009, AustraliaHealthy Skin Team, Wesfarmers Centre of Vaccines and Infectious Diseases, The Kids Research Institute Australia, Perth, WA 6009, AustraliaCentral Perth Skin Clinic, Perth, WA 6000, AustraliaCentral Perth Skin Clinic, Perth, WA 6000, AustraliaInstitute of Respiratory Health, QEII Medical Centre, Perth, WA 6009, AustraliaClinical Trials New Zealand, Hamilton 3204, New ZealandHealthy Skin Team, Wesfarmers Centre of Vaccines and Infectious Diseases, The Kids Research Institute Australia, Perth, WA 6009, AustraliaRecent interest in the diverse ecosystem of bacteria, fungi, parasites, and viruses that make up the skin microbiome has led to several studies investigating the microbiome in healthy skin and in a variety of dermatological conditions. An imbalance of the normal skin flora can cause some skin diseases, and current culture techniques are often unable to detect a microorganism to further our understanding of the clinical–microbiological correlates of disease and dysbiosis. Atopic dermatitis and rosacea are presentations that GPs often manage that may have an infective or microbiological component and can be challenging to treat. We aim to discuss the implications of the skin microbiome including the impact of dysbiosis on conditions such as these. We will also discuss some clinical pearls for initial and future directions of the management of conditions such as atopic dermatitis, rosacea, and hidradenitis suppurativa. Further research using culture-independent techniques is needed for conditions involving microbial dysbiosis to advance our knowledge of skin disease pathophysiology and guide future management.https://www.mdpi.com/2076-2607/13/1/54skin microbiomeatopic dermatitisrosaceahidradenitis suppurativa |
| spellingShingle | Anita Smith Roberta Dumbrava Noor-Ul-Huda Ghori Rachael Foster James Campbell Andrew Duthie Gerard Hoyne Marius Rademaker Asha C. Bowen An Overview of the Skin Microbiome, the Potential for Pathogen Shift, and Dysbiosis in Common Skin Pathologies Microorganisms skin microbiome atopic dermatitis rosacea hidradenitis suppurativa |
| title | An Overview of the Skin Microbiome, the Potential for Pathogen Shift, and Dysbiosis in Common Skin Pathologies |
| title_full | An Overview of the Skin Microbiome, the Potential for Pathogen Shift, and Dysbiosis in Common Skin Pathologies |
| title_fullStr | An Overview of the Skin Microbiome, the Potential for Pathogen Shift, and Dysbiosis in Common Skin Pathologies |
| title_full_unstemmed | An Overview of the Skin Microbiome, the Potential for Pathogen Shift, and Dysbiosis in Common Skin Pathologies |
| title_short | An Overview of the Skin Microbiome, the Potential for Pathogen Shift, and Dysbiosis in Common Skin Pathologies |
| title_sort | overview of the skin microbiome the potential for pathogen shift and dysbiosis in common skin pathologies |
| topic | skin microbiome atopic dermatitis rosacea hidradenitis suppurativa |
| url | https://www.mdpi.com/2076-2607/13/1/54 |
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