Reduced occludin expression is related to unfavorable tumor phenotype and poor prognosis in many different tumor types: A tissue microarray study on 16,870 tumors.

Reduced occludin expression is related to unfavorable tumor phenotype and poor prognosis in many different tumor types: A tissue microarray study on 16,870 tumors.

Occludin is a key component of tight junctions. Reduced occludin expression has been linked to cancer progression in individual tumor types, but a comprehensive and standardized analysis across human tumor types is lacking. To study the prevalence and clinical relevance of occludin expression in can...

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Main Authors: Seyma Büyücek, Florian Viehweger, Viktor Reiswich, Natalia Gorbokon, Viktoria Chirico, Christian Bernreuther, Florian Lutz, Simon Kind, Ria Schlichter, Sören Weidemann, Till S Clauditz, Andrea Hinsch, Ahmed Abdulwahab Bawahab, Frank Jacobsen, Andreas M Luebke, David Dum, Claudia Hube-Magg, Martina Kluth, Katharina Möller, Anne Menz, Andreas H Marx, Till Krech, Patrick Lebok, Christoph Fraune, Guido Sauter, Ronald Simon, Eike Burandt, Sarah Minner, Stefan Steurer, Maximilian Lennartz, Morton Freytag
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0321105
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