Resistance of <i>Wolbachia</i> to Trimethoprim: Insights into Genes Encoding Dihydrofolate Reductase, Thymidylate Synthase and Serine Hydroxymethyltransferase in the Rickettsiales

Resistance of <i>Wolbachia</i> to Trimethoprim: Insights into Genes Encoding Dihydrofolate Reductase, Thymidylate Synthase and Serine Hydroxymethyltransferase in the Rickettsiales

Bacterial and eukaryotic dihydrofolate reductase (DHFR) enzymes are essential for DNA synthesis and are differentially sensitive to the competitive inhibitors trimethoprim and methotrexate. Unexpectedly, trimethoprim did not reduce <i>Wolbachia</i> abundance, and the <i>w</i>...

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Bibliographic Details
Main Author:	Ann M. Fallon
Format:	Article
Language:	English
Published:	MDPI AG 2024-12-01
Series:	Insects
Subjects:	<i>Wolbachia</i> dihydrofolate reductase thymidylate synthase trimethoprim insect cell line one-carbon transfer reactions
Online Access:	https://www.mdpi.com/2075-4450/16/1/18
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