Long-term functional outcomes in patients with isolated cerebellar infarction: the KOSCO study
BackgroundThere are relatively few reports on the long-term sequential functional recovery and prognosis in patients with cerebellar infarction. The aim of this study was to investigate the long-term recovery of multifaceted functional outcomes up to 36 months after onset and the functional prognosi...
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Frontiers Media S.A.
2025-03-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1541245/full |
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| author | Ho Seok Lee Min Kyun Sohn Jongmin Lee Deog Young Kim Yong-Il Shin Gyung-Jae Oh Yang-Soo Lee Min Cheol Joo So Young Lee Min-Keun Song Junhee Han Jeonghoon Ahn Young-Hoon Lee Dae Hyun Kim Young-Taek Kim Yun-Hee Kim Won Hyuk Chang Won Hyuk Chang |
| author_facet | Ho Seok Lee Min Kyun Sohn Jongmin Lee Deog Young Kim Yong-Il Shin Gyung-Jae Oh Yang-Soo Lee Min Cheol Joo So Young Lee Min-Keun Song Junhee Han Jeonghoon Ahn Young-Hoon Lee Dae Hyun Kim Young-Taek Kim Yun-Hee Kim Won Hyuk Chang Won Hyuk Chang |
| author_sort | Ho Seok Lee |
| collection | DOAJ |
| description | BackgroundThere are relatively few reports on the long-term sequential functional recovery and prognosis in patients with cerebellar infarction. The aim of this study was to investigate the long-term recovery of multifaceted functional outcomes up to 36 months after onset and the functional prognosis of isolated cerebellar infarction.MethodsThis study was a retrospective analysis of the Korean Stroke Cohort for Functioning and Rehabilitation (KOSCO) data up to 36 months after onset. Isolated cerebellar infarction was defined as the presence of lesions in the cerebellum without lesions in other brain parenchyma. We assessed multifaceted functional domains, including motor (Fugl-Meyer Assessment, FMA), ambulatory (Functional Ambulation Category, FAC), cognitive (Korean Mini-Mental State Examination, K-MMSE), swallowing (American Speech-Language-Hearing Association National Outcome Measurement System Swallowing Scale, ASHA-NOMS), and language functions (Short version of the Korean Frenchay Aphasia Screening Test, Short K-FAST), using serial measurements. In addition, functional outcome was assessed with the Functional Independence Measure (FIM) up to 36 months after onset.ResultsAmong 390 screened isolated cerebellar infarction patients, a total of 183 patients were included in this study. Cognitive (mean[SD] of K-MMSE 27.6 ± 3.6) and swallowing (ASHA-NOMS 6.8 ± 0.7) functions showed significant improvement up to 3 months (p < 0.05). Motor (FMA 98.8 ± 3.8) and language (ASHA-NOMS 6.9 ± 0.4) functions improved significantly up to 6 months (p < 0.05). Furthermore, ambulatory function (FAC 4.7 ± 0.9) and functional independency (FIM 122.2 ± 12.0) continued to improve up to 12 months (p < 0.05). Vascular territory involving superior cerebellar artery, older age, female sex, and greater initial severity were identified as negative independent prognostic factors predicting functional outcome measured by FIM at 12 months after stroke.ConclusionThe plateau of recovery in multifaceted functional outcomes varied among patients with cerebellar infarction. Functional independence plateaued at 12 months and showed a relatively favorable prognosis up to 36 months after stroke. |
| format | Article |
| id | doaj-art-ee719aca3b884262b1f3d4abde7f12f6 |
| institution | DOAJ |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
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| spelling | doaj-art-ee719aca3b884262b1f3d4abde7f12f62025-08-20T02:58:29ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-03-011610.3389/fneur.2025.15412451541245Long-term functional outcomes in patients with isolated cerebellar infarction: the KOSCO studyHo Seok Lee0Min Kyun Sohn1Jongmin Lee2Deog Young Kim3Yong-Il Shin4Gyung-Jae Oh5Yang-Soo Lee6Min Cheol Joo7So Young Lee8Min-Keun Song9Junhee Han10Jeonghoon Ahn11Young-Hoon Lee12Dae Hyun Kim13Young-Taek Kim14Yun-Hee Kim15Won Hyuk Chang16Won Hyuk Chang17Department of Physical and Rehabilitation Medicine, Center for Prevention and Rehabilitation, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of KoreaDepartment of Rehabilitation Medicine, College of Medicine, Chungnam National University, Daejeon, Republic of KoreaDepartment of Rehabilitation Medicine, Konkuk University School of Medicine, Seoul, Republic of KoreaDepartment and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul, Republic of KoreaDepartment of Rehabilitation Medicine, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Yangsan, Republic of KoreaDepartment of Preventive Medicine, Wonkwang University, School of Medicine, Iksan, Republic of KoreaDepartment of Rehabilitation Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of KoreaDepartment of Rehabilitation Medicine, Wonkwang University School of Medicine, Iksan, Republic of KoreaDepartment of Rehabilitation Medicine, Jeju National University Hospital, Jeju National University School of Medicine, Jeju City, Republic of Korea0Department of Physical and Rehabilitation Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea1Department of Statistics, Hallym University, Chuncheon, Republic of Korea2Department of Health Convergence, Ewha Womans University, Seoul, Republic of KoreaDepartment of Preventive Medicine, Wonkwang University, School of Medicine, Iksan, Republic of KoreaDepartment of Physical and Rehabilitation Medicine, Center for Prevention and Rehabilitation, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea3Department of Preventive Medicine, Chungnam National University Hospital, Daejeon, Republic of Korea4Department of Physical and Rehabilitation Medicine, Sungkyunkwan University School of Medicine, Suwon, Republic of KoreaDepartment of Physical and Rehabilitation Medicine, Center for Prevention and Rehabilitation, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea5Department of Health Science and Technology, Department of Medical Device Management and Research, SAIHST, Sungkyunkwan University, Seoul, Republic of KoreaBackgroundThere are relatively few reports on the long-term sequential functional recovery and prognosis in patients with cerebellar infarction. The aim of this study was to investigate the long-term recovery of multifaceted functional outcomes up to 36 months after onset and the functional prognosis of isolated cerebellar infarction.MethodsThis study was a retrospective analysis of the Korean Stroke Cohort for Functioning and Rehabilitation (KOSCO) data up to 36 months after onset. Isolated cerebellar infarction was defined as the presence of lesions in the cerebellum without lesions in other brain parenchyma. We assessed multifaceted functional domains, including motor (Fugl-Meyer Assessment, FMA), ambulatory (Functional Ambulation Category, FAC), cognitive (Korean Mini-Mental State Examination, K-MMSE), swallowing (American Speech-Language-Hearing Association National Outcome Measurement System Swallowing Scale, ASHA-NOMS), and language functions (Short version of the Korean Frenchay Aphasia Screening Test, Short K-FAST), using serial measurements. In addition, functional outcome was assessed with the Functional Independence Measure (FIM) up to 36 months after onset.ResultsAmong 390 screened isolated cerebellar infarction patients, a total of 183 patients were included in this study. Cognitive (mean[SD] of K-MMSE 27.6 ± 3.6) and swallowing (ASHA-NOMS 6.8 ± 0.7) functions showed significant improvement up to 3 months (p < 0.05). Motor (FMA 98.8 ± 3.8) and language (ASHA-NOMS 6.9 ± 0.4) functions improved significantly up to 6 months (p < 0.05). Furthermore, ambulatory function (FAC 4.7 ± 0.9) and functional independency (FIM 122.2 ± 12.0) continued to improve up to 12 months (p < 0.05). Vascular territory involving superior cerebellar artery, older age, female sex, and greater initial severity were identified as negative independent prognostic factors predicting functional outcome measured by FIM at 12 months after stroke.ConclusionThe plateau of recovery in multifaceted functional outcomes varied among patients with cerebellar infarction. Functional independence plateaued at 12 months and showed a relatively favorable prognosis up to 36 months after stroke.https://www.frontiersin.org/articles/10.3389/fneur.2025.1541245/fullischemic strokecerebellumlong-term outcomefunctional prognosisrecovery |
| spellingShingle | Ho Seok Lee Min Kyun Sohn Jongmin Lee Deog Young Kim Yong-Il Shin Gyung-Jae Oh Yang-Soo Lee Min Cheol Joo So Young Lee Min-Keun Song Junhee Han Jeonghoon Ahn Young-Hoon Lee Dae Hyun Kim Young-Taek Kim Yun-Hee Kim Won Hyuk Chang Won Hyuk Chang Long-term functional outcomes in patients with isolated cerebellar infarction: the KOSCO study Frontiers in Neurology ischemic stroke cerebellum long-term outcome functional prognosis recovery |
| title | Long-term functional outcomes in patients with isolated cerebellar infarction: the KOSCO study |
| title_full | Long-term functional outcomes in patients with isolated cerebellar infarction: the KOSCO study |
| title_fullStr | Long-term functional outcomes in patients with isolated cerebellar infarction: the KOSCO study |
| title_full_unstemmed | Long-term functional outcomes in patients with isolated cerebellar infarction: the KOSCO study |
| title_short | Long-term functional outcomes in patients with isolated cerebellar infarction: the KOSCO study |
| title_sort | long term functional outcomes in patients with isolated cerebellar infarction the kosco study |
| topic | ischemic stroke cerebellum long-term outcome functional prognosis recovery |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1541245/full |
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