The fusion subunit vaccine L-DBF protects aged mice against heterologous lethal Shigella challenge after prior exposure

The fusion subunit vaccine L-DBF protects aged mice against heterologous lethal Shigella challenge after prior exposure

Shigellosis is among the top causes of bacterial diarrhea with significantly high morbidity and mortality for children under five years of age in low- and middle-income countries. Unfortunately, there are currently no licensed vaccines to prevent shigellosis. Our laboratory has developed the protein...

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Bibliographic Details
Main Authors: Md Shafiullah Parvej, Ti Lu, Suhrid Maiti, Zackary K. Dietz, Debaki R. Howlader, Mst Nusrat Zahan, Alexa Cato, Satabdi Biswas, William D. Picking, Wendy L. Picking
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
Shigella
subunit vaccine
aged mice
intranasal vaccination
pre-exposure
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1586537/full
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