Comparison of neurodevelopmental outcome in late-preterm and term neonates at 9-month corrected age
Background: Borderline premature birth can result in altered brain function and can present as inadequate neurological development leading to various neurological problems in premature infants. Further depending on whether birth is preterm or borderline preterm neurodevelopmental outcome can differ....
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | MRIMS Journal of Health Sciences |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/mjhs.mjhs_66_23 |
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| Summary: | Background:
Borderline premature birth can result in altered brain function and can present as inadequate neurological development leading to various neurological problems in premature infants. Further depending on whether birth is preterm or borderline preterm neurodevelopmental outcome can differ.
Objective:
The objective of the study was to compare neurodevelopmental outcome in late-preterm and term neonates at 9-month corrected age.
Materials and Methods:
A prospective cohort study was conducted among the two groups with 121 and 114 subjects each. All neonates were examined within the first 24 h of birth and then followed till discharge and again followed at 9 months. Gestational age at birth was assessed using the last menstrual period, antenatal ultrasonography, and modified New Ballard score. Neurodevelopmental parameters were assessed using Denver’s II developmental screening test at nine months.
Results:
Weight, maturity, and Ballard’s score were significantly more in term neonates compared to late-preterm neonates, but head circumference was comparable. All parameters at birth in both the groups were comparable. All neurodevelopmental parameters in the two groups were comparable. However, parameters such as not able to self-feed, not able to pass cubes, and not able to take two cubes were significantly delayed in late-preterm infants compared to term infants. Late preterm neonates were at increased risk of [OR=6.89 (95% CI=1.043-158.8)] and [RR=1.742 (95% CI=1.301-2.334)]. Fine motor milestone was significantly delayed in late-preterm individuals. In rest, other milestones including difference were not significant.
Conclusion:
The neurodevelopment among late-preterm neonates was lagging in some aspects at 9 months. Hence, they should be given special attention. |
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| ISSN: | 2321-7006 2321-7294 |