Selective Retention of an Inactive Allele of the DKK2 Tumor Suppressor Gene in Hepatocellular Carcinoma.

Selective Retention of an Inactive Allele of the DKK2 Tumor Suppressor Gene in Hepatocellular Carcinoma.

In an effort to identify the functional alleles associated with hepatocellular carcinoma (HCC), we investigated 152 genes found in the 4q21-25 region that exhibited loss of heterozygosity (LOH). A total of 2,293 pairs of primers were designed for 1,449 exonic and upstream promoter regions to amplify...

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Main Authors: Yung-Feng Lin, Ling-Hui Li, Chih-Hung Lin, Mei-Hua Tsou, Ming-Tai Kiffer Chuang, Keh-Ming Wu, Tsai-Lien Liao, Jian-Chiuan Li, Wei-Jie Wang, Angela Tomita, Beverly Tomita, Shiu-Feng Huang, Shih-Feng Tsai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-05-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1006051&type=printable
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