A randomized non-inferiority trial of 577nm subthreshold micropulse laser versus half-dose photodynamic therapy for acute central serous chorioretinopathy
Purpose: To compare the effectiveness of 577nm subthreshold micropulse laser (SML) with half-dose photodynamic therapy (Hd-PDT) for acute central serous chorioretinopathy (CSC). Method: A non-inferiority clinical trial was performed with a non-inferiority margin of eight letters. Sixty-eight eyes of...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-02-01
|
| Series: | Photodiagnosis and Photodynamic Therapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S157210002300635X |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846128288634765312 |
|---|---|
| author | Lijun Zhou Chuangxin Huang Zijing Li Tu Lu Hongkun Zhao Cong Li Qifeng Cong Jiandong Liang Xiaojing Zhong Ling Jin Lin Lu Chenjin Jin |
| author_facet | Lijun Zhou Chuangxin Huang Zijing Li Tu Lu Hongkun Zhao Cong Li Qifeng Cong Jiandong Liang Xiaojing Zhong Ling Jin Lin Lu Chenjin Jin |
| author_sort | Lijun Zhou |
| collection | DOAJ |
| description | Purpose: To compare the effectiveness of 577nm subthreshold micropulse laser (SML) with half-dose photodynamic therapy (Hd-PDT) for acute central serous chorioretinopathy (CSC). Method: A non-inferiority clinical trial was performed with a non-inferiority margin of eight letters. Sixty-eight eyes of 68 patients with acute CSC were randomized to the Hd-PDT group or 577 nm SML group. Best-corrected visual acuity (BCVA ), the subretinal fluid (SRF), and the central foveal thickness (CFT) were evaluated at 6 months. Results: The visual acuity significantly improved from 70.38 ± 10.37 at baseline to 83.24 ± 3.03 at 6 months after treatment in the SML group (P < 0.001), from 71.09 ± 10.50 to 84.35 ± 2.09 in the PDT group (P < 0.001). SML was non-inferior to the PDT (mean difference: -0.41, 95% CI: -5.51 – 4.68, P = 0.0021). At the endpoint, CFT was significantly reduced in the two groups, but no statistical difference (P = 0.7694). The complete resolution of SRF reached 82.35% (28/34) in the SML group and 91.18% (31/34) in the PDT group, respectively,but no statistical difference (P = 0.3724). Conclusions: SML was non-inferiority to half-dose PDT in improving the visual acuity for CSC, and it is a viable alternative, especially when the verteporfin in PDT is unavailable. |
| format | Article |
| id | doaj-art-ee6429ab691b49b7a85fa451bc0dbda4 |
| institution | Kabale University |
| issn | 1572-1000 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-ee6429ab691b49b7a85fa451bc0dbda42024-12-11T05:55:15ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002024-02-0145103908A randomized non-inferiority trial of 577nm subthreshold micropulse laser versus half-dose photodynamic therapy for acute central serous chorioretinopathyLijun Zhou0Chuangxin Huang1Zijing Li2Tu Lu3Hongkun Zhao4Cong Li5Qifeng Cong6Jiandong Liang7Xiaojing Zhong8Ling Jin9Lin Lu10Chenjin Jin11State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, 54 South Xianlie Road, Guangzhou 510060, ChinaState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, 54 South Xianlie Road, Guangzhou 510060, ChinaState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, 54 South Xianlie Road, Guangzhou 510060, China; Sun Yat-sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, ChinaState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, 54 South Xianlie Road, Guangzhou 510060, ChinaThe Affiliated Hospital of Yunnan University, The Second People's Hospital of Yunnan Province, Kunming, Yunnan Province, ChinaState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, 54 South Xianlie Road, Guangzhou 510060, ChinaDepartment of Ophthalmology, Third People's Hospital of Dalian, Dalian Medical University, Dalian, ChinaState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, 54 South Xianlie Road, Guangzhou 510060, ChinaState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, 54 South Xianlie Road, Guangzhou 510060, ChinaState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, 54 South Xianlie Road, Guangzhou 510060, ChinaState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, 54 South Xianlie Road, Guangzhou 510060, ChinaState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, 54 South Xianlie Road, Guangzhou 510060, China; Correspondence author.Purpose: To compare the effectiveness of 577nm subthreshold micropulse laser (SML) with half-dose photodynamic therapy (Hd-PDT) for acute central serous chorioretinopathy (CSC). Method: A non-inferiority clinical trial was performed with a non-inferiority margin of eight letters. Sixty-eight eyes of 68 patients with acute CSC were randomized to the Hd-PDT group or 577 nm SML group. Best-corrected visual acuity (BCVA ), the subretinal fluid (SRF), and the central foveal thickness (CFT) were evaluated at 6 months. Results: The visual acuity significantly improved from 70.38 ± 10.37 at baseline to 83.24 ± 3.03 at 6 months after treatment in the SML group (P < 0.001), from 71.09 ± 10.50 to 84.35 ± 2.09 in the PDT group (P < 0.001). SML was non-inferior to the PDT (mean difference: -0.41, 95% CI: -5.51 – 4.68, P = 0.0021). At the endpoint, CFT was significantly reduced in the two groups, but no statistical difference (P = 0.7694). The complete resolution of SRF reached 82.35% (28/34) in the SML group and 91.18% (31/34) in the PDT group, respectively,but no statistical difference (P = 0.3724). Conclusions: SML was non-inferiority to half-dose PDT in improving the visual acuity for CSC, and it is a viable alternative, especially when the verteporfin in PDT is unavailable.http://www.sciencedirect.com/science/article/pii/S157210002300635XSubthreshold micropulse laserHalf-dose photodynamic therapyCentral serous chorioretinopathyPhotodynamic therapy |
| spellingShingle | Lijun Zhou Chuangxin Huang Zijing Li Tu Lu Hongkun Zhao Cong Li Qifeng Cong Jiandong Liang Xiaojing Zhong Ling Jin Lin Lu Chenjin Jin A randomized non-inferiority trial of 577nm subthreshold micropulse laser versus half-dose photodynamic therapy for acute central serous chorioretinopathy Photodiagnosis and Photodynamic Therapy Subthreshold micropulse laser Half-dose photodynamic therapy Central serous chorioretinopathy Photodynamic therapy |
| title | A randomized non-inferiority trial of 577nm subthreshold micropulse laser versus half-dose photodynamic therapy for acute central serous chorioretinopathy |
| title_full | A randomized non-inferiority trial of 577nm subthreshold micropulse laser versus half-dose photodynamic therapy for acute central serous chorioretinopathy |
| title_fullStr | A randomized non-inferiority trial of 577nm subthreshold micropulse laser versus half-dose photodynamic therapy for acute central serous chorioretinopathy |
| title_full_unstemmed | A randomized non-inferiority trial of 577nm subthreshold micropulse laser versus half-dose photodynamic therapy for acute central serous chorioretinopathy |
| title_short | A randomized non-inferiority trial of 577nm subthreshold micropulse laser versus half-dose photodynamic therapy for acute central serous chorioretinopathy |
| title_sort | randomized non inferiority trial of 577nm subthreshold micropulse laser versus half dose photodynamic therapy for acute central serous chorioretinopathy |
| topic | Subthreshold micropulse laser Half-dose photodynamic therapy Central serous chorioretinopathy Photodynamic therapy |
| url | http://www.sciencedirect.com/science/article/pii/S157210002300635X |
| work_keys_str_mv | AT lijunzhou arandomizednoninferioritytrialof577nmsubthresholdmicropulselaserversushalfdosephotodynamictherapyforacutecentralserouschorioretinopathy AT chuangxinhuang arandomizednoninferioritytrialof577nmsubthresholdmicropulselaserversushalfdosephotodynamictherapyforacutecentralserouschorioretinopathy AT zijingli arandomizednoninferioritytrialof577nmsubthresholdmicropulselaserversushalfdosephotodynamictherapyforacutecentralserouschorioretinopathy AT tulu arandomizednoninferioritytrialof577nmsubthresholdmicropulselaserversushalfdosephotodynamictherapyforacutecentralserouschorioretinopathy AT hongkunzhao arandomizednoninferioritytrialof577nmsubthresholdmicropulselaserversushalfdosephotodynamictherapyforacutecentralserouschorioretinopathy AT congli arandomizednoninferioritytrialof577nmsubthresholdmicropulselaserversushalfdosephotodynamictherapyforacutecentralserouschorioretinopathy AT qifengcong arandomizednoninferioritytrialof577nmsubthresholdmicropulselaserversushalfdosephotodynamictherapyforacutecentralserouschorioretinopathy AT jiandongliang arandomizednoninferioritytrialof577nmsubthresholdmicropulselaserversushalfdosephotodynamictherapyforacutecentralserouschorioretinopathy AT xiaojingzhong arandomizednoninferioritytrialof577nmsubthresholdmicropulselaserversushalfdosephotodynamictherapyforacutecentralserouschorioretinopathy AT lingjin arandomizednoninferioritytrialof577nmsubthresholdmicropulselaserversushalfdosephotodynamictherapyforacutecentralserouschorioretinopathy AT linlu arandomizednoninferioritytrialof577nmsubthresholdmicropulselaserversushalfdosephotodynamictherapyforacutecentralserouschorioretinopathy AT chenjinjin arandomizednoninferioritytrialof577nmsubthresholdmicropulselaserversushalfdosephotodynamictherapyforacutecentralserouschorioretinopathy AT lijunzhou randomizednoninferioritytrialof577nmsubthresholdmicropulselaserversushalfdosephotodynamictherapyforacutecentralserouschorioretinopathy AT chuangxinhuang randomizednoninferioritytrialof577nmsubthresholdmicropulselaserversushalfdosephotodynamictherapyforacutecentralserouschorioretinopathy AT zijingli randomizednoninferioritytrialof577nmsubthresholdmicropulselaserversushalfdosephotodynamictherapyforacutecentralserouschorioretinopathy AT tulu randomizednoninferioritytrialof577nmsubthresholdmicropulselaserversushalfdosephotodynamictherapyforacutecentralserouschorioretinopathy AT hongkunzhao randomizednoninferioritytrialof577nmsubthresholdmicropulselaserversushalfdosephotodynamictherapyforacutecentralserouschorioretinopathy AT congli randomizednoninferioritytrialof577nmsubthresholdmicropulselaserversushalfdosephotodynamictherapyforacutecentralserouschorioretinopathy AT qifengcong randomizednoninferioritytrialof577nmsubthresholdmicropulselaserversushalfdosephotodynamictherapyforacutecentralserouschorioretinopathy AT jiandongliang randomizednoninferioritytrialof577nmsubthresholdmicropulselaserversushalfdosephotodynamictherapyforacutecentralserouschorioretinopathy AT xiaojingzhong randomizednoninferioritytrialof577nmsubthresholdmicropulselaserversushalfdosephotodynamictherapyforacutecentralserouschorioretinopathy AT lingjin randomizednoninferioritytrialof577nmsubthresholdmicropulselaserversushalfdosephotodynamictherapyforacutecentralserouschorioretinopathy AT linlu randomizednoninferioritytrialof577nmsubthresholdmicropulselaserversushalfdosephotodynamictherapyforacutecentralserouschorioretinopathy AT chenjinjin randomizednoninferioritytrialof577nmsubthresholdmicropulselaserversushalfdosephotodynamictherapyforacutecentralserouschorioretinopathy |