A study of compressibility and compactibility of directly compressible tableting materials containing tramadol hydrochloride
The paper evaluates and compares the compressibility and compactibility of directly compressible tableting materials for the preparation of hydrophilic gel matrix tablets containing tramadol hydrochloride and the coprocessed dry binders Prosolv® SMCC 90 and Disintequik™ MCC 25. The selected types of...
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| Format: | Article |
| Language: | English |
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Sciendo
2016-09-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.1515/acph-2016-0034 |
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| author | Mužíková Jitka Kubíčková Alena |
| author_facet | Mužíková Jitka Kubíčková Alena |
| author_sort | Mužíková Jitka |
| collection | DOAJ |
| description | The paper evaluates and compares the compressibility and compactibility of directly compressible tableting materials for the preparation of hydrophilic gel matrix tablets containing tramadol hydrochloride and the coprocessed dry binders Prosolv® SMCC 90 and Disintequik™ MCC 25. The selected types of hypromellose are Methocel™ Premium K4M and Methocel™ Premium K100M in 30 and 50 % concentrations, the lubricant being magnesium stearate in a 1 % concentration. Compressibility is evaluated by means of the energy profile of compression process and compactibility by the tensile strength of tablets. The values of total energy of compression and plasticity were higher in the tableting materials containing Prosolv® SMCC 90 than in those containing Disintequik™ MCC 25. Tramadol slightly decreased the values of total energy of compression and plasticity. Tableting materials containing Prosolv® SMCC 90 yielded stronger tablets. Tramadol decreased the strength of tablets from both coprocessed dry binders. |
| format | Article |
| id | doaj-art-ee619087659547dabde7cd85dc8ad6b7 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2016-09-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-ee619087659547dabde7cd85dc8ad6b72025-02-02T09:44:22ZengSciendoActa Pharmaceutica1846-95582016-09-0166343344110.1515/acph-2016-0034acph-2016-0034A study of compressibility and compactibility of directly compressible tableting materials containing tramadol hydrochlorideMužíková Jitka0Kubíčková Alena1Department of Pharmaceutical Technology Charles University in Prague Faculty of Pharmacy in Hradec Králové Czech RepublicDepartment of Pharmaceutical Technology Charles University in Prague Faculty of Pharmacy in Hradec Králové Czech RepublicThe paper evaluates and compares the compressibility and compactibility of directly compressible tableting materials for the preparation of hydrophilic gel matrix tablets containing tramadol hydrochloride and the coprocessed dry binders Prosolv® SMCC 90 and Disintequik™ MCC 25. The selected types of hypromellose are Methocel™ Premium K4M and Methocel™ Premium K100M in 30 and 50 % concentrations, the lubricant being magnesium stearate in a 1 % concentration. Compressibility is evaluated by means of the energy profile of compression process and compactibility by the tensile strength of tablets. The values of total energy of compression and plasticity were higher in the tableting materials containing Prosolv® SMCC 90 than in those containing Disintequik™ MCC 25. Tramadol slightly decreased the values of total energy of compression and plasticity. Tableting materials containing Prosolv® SMCC 90 yielded stronger tablets. Tramadol decreased the strength of tablets from both coprocessed dry binders.https://doi.org/10.1515/acph-2016-0034tramadol hydrochloridehydrophilic matrix tabletscoprocessed dry binderhypromelloseenergy profile of compressiontensile strength of tablets |
| spellingShingle | Mužíková Jitka Kubíčková Alena A study of compressibility and compactibility of directly compressible tableting materials containing tramadol hydrochloride Acta Pharmaceutica tramadol hydrochloride hydrophilic matrix tablets coprocessed dry binder hypromellose energy profile of compression tensile strength of tablets |
| title | A study of compressibility and compactibility of directly compressible tableting materials containing tramadol hydrochloride |
| title_full | A study of compressibility and compactibility of directly compressible tableting materials containing tramadol hydrochloride |
| title_fullStr | A study of compressibility and compactibility of directly compressible tableting materials containing tramadol hydrochloride |
| title_full_unstemmed | A study of compressibility and compactibility of directly compressible tableting materials containing tramadol hydrochloride |
| title_short | A study of compressibility and compactibility of directly compressible tableting materials containing tramadol hydrochloride |
| title_sort | study of compressibility and compactibility of directly compressible tableting materials containing tramadol hydrochloride |
| topic | tramadol hydrochloride hydrophilic matrix tablets coprocessed dry binder hypromellose energy profile of compression tensile strength of tablets |
| url | https://doi.org/10.1515/acph-2016-0034 |
| work_keys_str_mv | AT muzikovajitka astudyofcompressibilityandcompactibilityofdirectlycompressibletabletingmaterialscontainingtramadolhydrochloride AT kubickovaalena astudyofcompressibilityandcompactibilityofdirectlycompressibletabletingmaterialscontainingtramadolhydrochloride AT muzikovajitka studyofcompressibilityandcompactibilityofdirectlycompressibletabletingmaterialscontainingtramadolhydrochloride AT kubickovaalena studyofcompressibilityandcompactibilityofdirectlycompressibletabletingmaterialscontainingtramadolhydrochloride |