Lipid oxidation in young patients with newly diagnosed bipolar disorder and their relatives
Abstract Background Oxidative stress may be involved in the pathophysiology of bipolar disorder (BD). Malondialdehyde (MDA), a product of fatty acid peroxidation has been proposed as a trait marker of BD associated with familial risk. However, little is known about MDA levels in young patients newly...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-03-01
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| Series: | International Journal of Bipolar Disorders |
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| Online Access: | https://doi.org/10.1186/s40345-025-00377-8 |
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| author | Sharleny Stanislaus Klara Coello Hanne Lie Kjaerstad Kimie Stefanie Ormstrup Sletved Kamilla Woznica Miskowiak Maria Faurholt-Jepsen Klaus Munkholm Henrik Enghusen Poulsen Maj Vinberg Jens Lykkesfeldt Lars V. Kessing |
| author_facet | Sharleny Stanislaus Klara Coello Hanne Lie Kjaerstad Kimie Stefanie Ormstrup Sletved Kamilla Woznica Miskowiak Maria Faurholt-Jepsen Klaus Munkholm Henrik Enghusen Poulsen Maj Vinberg Jens Lykkesfeldt Lars V. Kessing |
| author_sort | Sharleny Stanislaus |
| collection | DOAJ |
| description | Abstract Background Oxidative stress may be involved in the pathophysiology of bipolar disorder (BD). Malondialdehyde (MDA), a product of fatty acid peroxidation has been proposed as a trait marker of BD associated with familial risk. However, little is known about MDA levels in young patients newly diagnosed with BD and their unaffected first-degree relatives (UR). Methods In this substudy of the ongoing longitudinal “Bipolar Illness Onset study”, we included baseline data and first, we compared fasting blood MDA levels in 130 young patients aged 15–25 years newly diagnosed with BD, 57 UR, and 88 healthy control individuals (HC). Second, we investigated associations between levels of MDA and illness variables in patients with BD. Third, we investigated associations between MDA levels and nucleoside damage by oxidation measured in urine. Fasting MDA levels from blood samples were measured using high-performance liquid chromatography (HPLC). Results In linear mixed effect models, adjusted for age and sex, MDA levels did not differ between patients with BD, UR, and HC, respectively. In patients with BD, we found no associations between levels of MDA and duration of illness, number of affective phases, illness onset or oxidatively damaged RNA and DNA. Conclusion Against expectations, MDA levels did not differ between young patients with BD, UR, and HC, thus, our findings did not support MDA being a state or a trait marker of BD associated with familial risk. |
| format | Article |
| id | doaj-art-ee618bf94a524299a7cb95bf5165d2ad |
| institution | DOAJ |
| issn | 2194-7511 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | International Journal of Bipolar Disorders |
| spelling | doaj-art-ee618bf94a524299a7cb95bf5165d2ad2025-08-20T02:56:10ZengSpringerOpenInternational Journal of Bipolar Disorders2194-75112025-03-0113111110.1186/s40345-025-00377-8Lipid oxidation in young patients with newly diagnosed bipolar disorder and their relativesSharleny Stanislaus0Klara Coello1Hanne Lie Kjaerstad2Kimie Stefanie Ormstrup Sletved3Kamilla Woznica Miskowiak4Maria Faurholt-Jepsen5Klaus Munkholm6Henrik Enghusen Poulsen7Maj Vinberg8Jens Lykkesfeldt9Lars V. Kessing10Copenhagen Affective Disorders Research Centre (CADIC), Psychiatric Center CopenhagenCopenhagen Affective Disorders Research Centre (CADIC), Psychiatric Center CopenhagenCopenhagen Affective Disorders Research Centre (CADIC), Psychiatric Center CopenhagenCopenhagen Affective Disorders Research Centre (CADIC), Psychiatric Center CopenhagenCopenhagen Affective Disorders Research Centre (CADIC), Psychiatric Center CopenhagenCopenhagen Affective Disorders Research Centre (CADIC), Psychiatric Center CopenhagenCopenhagen Affective Disorders Research Centre (CADIC), Psychiatric Center CopenhagenDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of CopenhagenDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of CopenhagenDepartment of Veterinary and Animal SciencesCopenhagen Affective Disorders Research Centre (CADIC), Psychiatric Center CopenhagenAbstract Background Oxidative stress may be involved in the pathophysiology of bipolar disorder (BD). Malondialdehyde (MDA), a product of fatty acid peroxidation has been proposed as a trait marker of BD associated with familial risk. However, little is known about MDA levels in young patients newly diagnosed with BD and their unaffected first-degree relatives (UR). Methods In this substudy of the ongoing longitudinal “Bipolar Illness Onset study”, we included baseline data and first, we compared fasting blood MDA levels in 130 young patients aged 15–25 years newly diagnosed with BD, 57 UR, and 88 healthy control individuals (HC). Second, we investigated associations between levels of MDA and illness variables in patients with BD. Third, we investigated associations between MDA levels and nucleoside damage by oxidation measured in urine. Fasting MDA levels from blood samples were measured using high-performance liquid chromatography (HPLC). Results In linear mixed effect models, adjusted for age and sex, MDA levels did not differ between patients with BD, UR, and HC, respectively. In patients with BD, we found no associations between levels of MDA and duration of illness, number of affective phases, illness onset or oxidatively damaged RNA and DNA. Conclusion Against expectations, MDA levels did not differ between young patients with BD, UR, and HC, thus, our findings did not support MDA being a state or a trait marker of BD associated with familial risk.https://doi.org/10.1186/s40345-025-00377-8Bipolar disordersLipid oxidationMalondialdehydeHigh-riskAdolescence |
| spellingShingle | Sharleny Stanislaus Klara Coello Hanne Lie Kjaerstad Kimie Stefanie Ormstrup Sletved Kamilla Woznica Miskowiak Maria Faurholt-Jepsen Klaus Munkholm Henrik Enghusen Poulsen Maj Vinberg Jens Lykkesfeldt Lars V. Kessing Lipid oxidation in young patients with newly diagnosed bipolar disorder and their relatives International Journal of Bipolar Disorders Bipolar disorders Lipid oxidation Malondialdehyde High-risk Adolescence |
| title | Lipid oxidation in young patients with newly diagnosed bipolar disorder and their relatives |
| title_full | Lipid oxidation in young patients with newly diagnosed bipolar disorder and their relatives |
| title_fullStr | Lipid oxidation in young patients with newly diagnosed bipolar disorder and their relatives |
| title_full_unstemmed | Lipid oxidation in young patients with newly diagnosed bipolar disorder and their relatives |
| title_short | Lipid oxidation in young patients with newly diagnosed bipolar disorder and their relatives |
| title_sort | lipid oxidation in young patients with newly diagnosed bipolar disorder and their relatives |
| topic | Bipolar disorders Lipid oxidation Malondialdehyde High-risk Adolescence |
| url | https://doi.org/10.1186/s40345-025-00377-8 |
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