Crystal Structure and Biological Evaluation of Two Novel Organic-Inorganic Hybrid Materials as Antitumor Agents in the Treatment of Liver Cancer
Two novel organic-inorganic hybrid materials {(Hbiz)6[AsIII2AsVMoVI18O62]}·H2O (1, biz = benzimidazole) and (dim)[AsIII2AsVMoVI18O62] [2, dim = 1,6-bis(imidazol)hexane] have been successfully obtained by using the molybdenum arsenate and different N donor organic compounds and determined through X-r...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2018/9758197 |
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| author | Bao-Hua Song Chen Li Gui-Feng An |
| author_facet | Bao-Hua Song Chen Li Gui-Feng An |
| author_sort | Bao-Hua Song |
| collection | DOAJ |
| description | Two novel organic-inorganic hybrid materials {(Hbiz)6[AsIII2AsVMoVI18O62]}·H2O (1, biz = benzimidazole) and (dim)[AsIII2AsVMoVI18O62] [2, dim = 1,6-bis(imidazol)hexane] have been successfully obtained by using the molybdenum arsenate and different N donor organic compounds and determined through X-ray single-crystal diffraction technique. The in vitro cytotoxicity of compounds 1 and 2 was then investigated against three human liver tumor cell lines (SMMC7721, Bel-7402, and MHCC97) by MTT assay. It was found that the two compounds showed potent use as antitumor agents against the aforementioned cell lines. |
| format | Article |
| id | doaj-art-ee46af2fad154bf7bd4882bd692cf467 |
| institution | OA Journals |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-ee46af2fad154bf7bd4882bd692cf4672025-08-20T02:21:42ZengWileyJournal of Chemistry2090-90632090-90712018-01-01201810.1155/2018/97581979758197Crystal Structure and Biological Evaluation of Two Novel Organic-Inorganic Hybrid Materials as Antitumor Agents in the Treatment of Liver CancerBao-Hua Song0Chen Li1Gui-Feng An2Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia, ChinaInner Mongolia University for Nationalities, Tongliao, Inner Mongolia, ChinaInner Mongolia University for Nationalities, Tongliao, Inner Mongolia, ChinaTwo novel organic-inorganic hybrid materials {(Hbiz)6[AsIII2AsVMoVI18O62]}·H2O (1, biz = benzimidazole) and (dim)[AsIII2AsVMoVI18O62] [2, dim = 1,6-bis(imidazol)hexane] have been successfully obtained by using the molybdenum arsenate and different N donor organic compounds and determined through X-ray single-crystal diffraction technique. The in vitro cytotoxicity of compounds 1 and 2 was then investigated against three human liver tumor cell lines (SMMC7721, Bel-7402, and MHCC97) by MTT assay. It was found that the two compounds showed potent use as antitumor agents against the aforementioned cell lines.http://dx.doi.org/10.1155/2018/9758197 |
| spellingShingle | Bao-Hua Song Chen Li Gui-Feng An Crystal Structure and Biological Evaluation of Two Novel Organic-Inorganic Hybrid Materials as Antitumor Agents in the Treatment of Liver Cancer Journal of Chemistry |
| title | Crystal Structure and Biological Evaluation of Two Novel Organic-Inorganic Hybrid Materials as Antitumor Agents in the Treatment of Liver Cancer |
| title_full | Crystal Structure and Biological Evaluation of Two Novel Organic-Inorganic Hybrid Materials as Antitumor Agents in the Treatment of Liver Cancer |
| title_fullStr | Crystal Structure and Biological Evaluation of Two Novel Organic-Inorganic Hybrid Materials as Antitumor Agents in the Treatment of Liver Cancer |
| title_full_unstemmed | Crystal Structure and Biological Evaluation of Two Novel Organic-Inorganic Hybrid Materials as Antitumor Agents in the Treatment of Liver Cancer |
| title_short | Crystal Structure and Biological Evaluation of Two Novel Organic-Inorganic Hybrid Materials as Antitumor Agents in the Treatment of Liver Cancer |
| title_sort | crystal structure and biological evaluation of two novel organic inorganic hybrid materials as antitumor agents in the treatment of liver cancer |
| url | http://dx.doi.org/10.1155/2018/9758197 |
| work_keys_str_mv | AT baohuasong crystalstructureandbiologicalevaluationoftwonovelorganicinorganichybridmaterialsasantitumoragentsinthetreatmentoflivercancer AT chenli crystalstructureandbiologicalevaluationoftwonovelorganicinorganichybridmaterialsasantitumoragentsinthetreatmentoflivercancer AT guifengan crystalstructureandbiologicalevaluationoftwonovelorganicinorganichybridmaterialsasantitumoragentsinthetreatmentoflivercancer |